Hydroxypropylmethylcellulose (HPMC) ndi gulu losunthika lomwe limagwiritsidwa ntchito m'mafakitale osiyanasiyana kuphatikiza mankhwala, chakudya, zomangamanga ndi zodzola. Kumvetsetsa kapangidwe kake, kapangidwe kake, katundu ndi ntchito kumafuna kuphunzira mozama za kapangidwe kake ka mankhwala ndi kaphatikizidwe kake.
kapangidwe ndi kapangidwe
Cellulose Backbone: HPMC imachokera ku cellulose, polima wachilengedwe wopezeka m'makoma a cellulose. Ma cellulose amapangidwa ndi maunyolo aatali a glucose olumikizidwa pamodzi ndi ma β-1,4 glycosidic bond.
Methylation: Methylcellulose ndi kalambulabwalo wa HPMC ndipo amapangidwa pochiza mapadi ndi alkali ndi methyl chloride. Njirayi imaphatikizapo kusintha magulu a hydroxyl (-OH) pamsana wa cellulose ndi magulu a methyl (-CH3).
Hydroxypropylation: Pambuyo pa methylation, hydroxypropylation imachitika. Mu sitepe iyi, propylene oxide imakhudzidwa ndi methylated cellulose, ndikuyambitsa magulu a hydroxypropyl (-OCH2CHOHCH3) pamsana wa cellulose.
Degree of Substitution (DS): Mlingo wolowa m'malo umanena za kuchuluka kwa magulu a hydroxypropyl ndi methyl pagawo la shuga mu tcheni cha cellulose. Izi chizindikiro zimakhudza katundu HPMC, kuphatikizapo solubility ake, mamasukidwe akayendedwe, ndi makhalidwe matenthedwe.
kaphatikizidwe
Chithandizo cha alkaline: Ulusi wa cellulose umayamba kuthandizidwa ndi njira ya alkaline, nthawi zambiri sodium hydroxide (NaOH), kuti athyole ma intermolecular hydrogen bond ndikuwonjezera kupezeka kwamagulu a cellulose hydroxyl.
Methylation: Ma cellulose opangidwa ndi alkali amachitidwa ndi methyl chloride (CH3Cl) pansi pamikhalidwe yoyendetsedwa, zomwe zimapangitsa kuti m'malo mwa magulu a hydroxyl ndi magulu a methyl.
Hydroxypropylation: Ma cellulose a methylated amakumananso ndi propylene oxide (C3H6O) pamaso pa chothandizira monga sodium hydroxide. Izi zimabweretsa magulu a hydroxypropyl mu cellulose msana.
Neutralization ndi Chiyeretso: Neutralization reaction osakaniza kuchotsa maziko owonjezera. Zomwe zapezedwa zimadutsa njira zoyeretsera monga kusefera, kutsuka, ndi kuyanika kuti mupeze chomaliza cha HPMC.
khalidwe
Kusungunuka: HPMC imasungunuka m'madzi ndipo imapanga yankho lomveka bwino komanso lowoneka bwino. Kusungunuka kumadalira zinthu monga kuchuluka kwa kusintha, kulemera kwa maselo, ndi kutentha.
Viscosity: Mayankho a HPMC amawonetsa khalidwe la pseudoplastic, kutanthauza kuti kukhuthala kwawo kumachepa ndi kumeta ubweya wambiri. Viscosity imatha kuwongoleredwa posintha magawo monga DS, kulemera kwa maselo ndi kukhazikika.
Kupanga Makanema: HPMC imapanga makanema osinthika komanso owoneka bwino akatayidwa kuchokera kumadzi ake. Mafilimuwa amapeza ntchito mu zokutira, kulongedza ndi mankhwala.
Kukhazikika kwamafuta: HPMC imakhala yokhazikika pa kutentha kwina, pamwamba pomwe kuwonongeka kumachitika. Kukhazikika kwa kutentha kumatengera zinthu monga DS, chinyezi, komanso kupezeka kwa zowonjezera.
Malo ofunsira
Mankhwala: HPMC imagwiritsidwa ntchito kwambiri popanga mankhwala monga zokhuthala, zomangira, zopangira mafilimu ndi masamu omasulidwa mosalekeza. Imawongolera kuwonongeka kwa piritsi, kusungunuka ndi bioavailability.
Chakudya: M'makampani azakudya, HPMC imagwiritsidwa ntchito ngati chokhuthala, chokhazikika, emulsifier ndi chodzaza zinthu monga sosi, mavalidwe, zinthu zophika ndi mkaka.
Zomangamanga: HPMC imawonjezeredwa kumatope opangidwa ndi simenti, zomatira ndi matailosi kuti zithandizire kugwira ntchito, kusunga madzi komanso kumamatira. Imawongolera magwiridwe antchito a zida zomangira izi m'mikhalidwe yosiyanasiyana.
Zodzoladzola: HPMC imagwiritsidwa ntchito ngati thickener, emulsifier ndi stabilizer mu zodzoladzola formulations monga zonona, lotions ndi gels. Imapatsa zofunika rheological katundu ndi kumawonjezera mankhwala bata.
Hydroxypropyl methylcellulose (HPMC) ndi mankhwala ambiri opangidwa kuchokera ku cellulose kudzera mu methylation ndi hydroxypropylation process. Kapangidwe kake ka mankhwala, katundu ndi ntchito zake zimapangitsa kuti ikhale yofunika kwambiri m'mafakitale osiyanasiyana monga mankhwala, chakudya, zomangamanga ndi zodzoladzola. Kafukufuku wopitilira ndi chitukuko chaukadaulo wa HPMC akupitiliza kukulitsa zomwe angathe kugwiritsa ntchito ndikuwongolera magwiridwe antchito ake pamapangidwe osiyanasiyana.
Nthawi yotumiza: Feb-20-2024