Hydroxypropyl methylcellulose HPMC?

Hydroxypropyl methylcellulose HPMC ndi cellulose yopanda ionic yosakanikirana ndi ether yosakanikirana ndi ionic methylcarboxymethylcellulose. Sichichita ndi zitsulo zolemera. Kusiyana kwa zomwe zili mu hydroxypropyl methylcellulose, hydroxypropyl methylcellulose, ndi hydroxypropyl content ratio and viscosity of the oxygen free gene ali ndi mitundu yosiyana kwambiri potengera magwiridwe antchito. Mwachitsanzo, mitundu yokhala ndi methoxyl yambiri komanso yotsika ya hydroxypropyl imakhala ndi magwiridwe antchito osiyanasiyana. Pafupi ndi methylcellulose komanso mitundu yotsika ya methoxy. Poyerekeza ndi mitundu yokhala ndi ma hydroxypropyl apamwamba, magwiridwe ake ali pafupi ndi a hydroxypropyl methylcellulose opangidwa. Komabe, ngakhale mitundu iliyonse ili ndi gulu laling'ono la hydroxypropyl kapena gulu laling'ono la methoxy, pali kusiyana kwakukulu mu kusungunuka kwa zosungunulira za organic kapena kutentha kwa flocculation mu njira zamadzimadzi.

1. Kusungunuka kwa hydroxypropyl methylcellulose

Kusungunuka kwa hydroxypropyl methylcellulose m'madzi Hydroxypropyl methylcellulose kwenikweni ndi propylene oxide (methylhydroxypropyl ring) yosinthidwa methylcellulose, kotero imakhalabe ndi zinthu zomwezo monga methylcellulose Imakhala ndi zofanana zosungunuka m'madzi ozizira koma osasungunuka m'madzi otentha. Komabe, kutentha kwa gelling kwa hydroxypropyl yosinthidwa m'madzi otentha ndikokwera kwambiri kuposa methylcellulose. Mwachitsanzo, 2% hydroxypropyl methylcellulose yankho lamadzi lomwe lili ndi methoxy gulu DS=0.73 ndi gulu la hydroxypropyl MS=0.46 lili ndi kukhuthala kwa 500mpa pa 20°C. Kutentha kwa gel opangidwa ndi S kuli pafupi ndi 100 ° C, pamene methylcellulose pa kutentha komweko ndi pafupifupi 55 ° C. Ponena za kusungunuka kwake m'madzi, zasinthidwanso kwambiri. Mwachitsanzo, hydroxypropyl methylcellulose ikaphwanyidwa (mawonekedwe a tinthu ndi 0.2 ~ 0.5mm, kukhuthala kwa madzi 4% pa 20 ° C ndi 2pA · S, angagwiritsidwe ntchito kutentha popanda kuzizira. Kusungunula mosavuta m'madzi).

(2) The solubility wa hydroxypropyl methylcellulose mu organic solvents Kusungunuka kwa hydroxypropyl methylcellulose mu zosungunulira organic kulinso bwino kuposa methylcellulose. Methylcellulose imafuna methoxy m'malo digiri ya 2.1 The pamwamba mankhwala ali mkulu-makamakamakamakamakamakamakayendedwe hydroxypropyl methylcellulose ndi hydroxypropyl MS=1.5~1.8 ndi methoxy DS=0.2~1.0, ndi okwana m'malo digiri oposa 1.8, ndipo mosavuta sungunuka mu anhydrous methanol ndi anhydrous mayankho a ethanol. Thermoplastic ndi madzi sungunuka. Amasungunukanso mu ma hydrocarboni a chlorine monga methylene chloride ndi chloroform, ndi zosungunulira za organic monga acetone, mowa wa isopropyl ndi mowa wa diacetone. Kusungunuka kwake mu zosungunulira za organic ndikwabwino kuposa kusungunuka kwamadzi.

2. Zinthu zomwe zimakhudza kukhuthala kwa hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose viscosity factor Muyezo wa kukhuthala kwa hydroxypropyl methylcellulose ndi wofanana ndi ma cellulose ether ena, ndipo amayezedwa pa 20 ° C ndi 2% yamadzimadzi amadzimadzi monga muyezo. Kukhuthala kwa mankhwala omwewo kumawonjezeka pamene ndende ikuwonjezeka. Kwa mankhwala omwe ali ndi ndende yofanana ndi zolemera zosiyana za maselo, mankhwala omwe ali ndi kulemera kwakukulu kwa maselo amakhala ndi kukhuthala kwakukulu. Ubale wake ndi kutentha ndi wofanana ndi wa methylcellulose. Kutentha kumakwera, kukhuthala kumayamba kuchepa, koma ikafika kutentha kwina, kukhuthala kumatuluka mwadzidzidzi ndipo gelation imachitika. Low mamasukidwe akayendedwe mankhwala ndi apamwamba gelling kutentha kuposa mkulu mamasukidwe akayendedwe mankhwala. Mfundo ya gel sikuti imangokhudzana ndi kukhuthala kwa ether, komanso ikugwirizana ndi chiŵerengero cha magulu a methoxy ndi hydroxypropyl mu ether ndi chiwerengero chonse cha m'malo. Tiyenera kuzindikira kuti hydroxypropyl methylcellulose ndi pseudoplastic; njira zake zimakhala zokhazikika zikasungidwa kutentha kwa firiji ndipo siziwonetsa kuchepa kwa kukhuthala kulikonse, kupatula kuwonongeka kwa enzymatic.

3. Hydroxypropyl methylcellulose ndi asidi ndi alkali kugonjetsedwa

Hydroxypropyl methylcellulose ndi asidi ndi alkali kugonjetsedwa. Hydroxypropyl methyl cellulose ndi asidi ndi alkali kugonjetsedwa. Nthawi zambiri imakhala yokhazikika ndipo sidzakhudzidwa ndi mtengo wa pH wa PH2~12. Imatha kupirira kuchuluka kwa zidulo zofooka, monga formic acid, acetic acid, ndi mandimu. Acid, succinic acid, phosphoric acid koma acidic acid imakhala ndi zotsatira zochepetsera kukhuthala. Alkali monga caustic soda, caustic potaziyamu, ndi madzi a mandimu alibe mphamvu pa izo, koma zotsatira za kuwonjezeka pang'ono kukhuthala kwa yankho kumachepa pang'onopang'ono.

4. Hydroxypropyl methylcellulose ikhoza kusakanikirana

Hydroxypropyl methylcellulose yankho akhoza kusakaniza ndi madzi sungunuka polima mankhwala kupanga yunifolomu ndi mandala njira ndi apamwamba mamasukidwe akayendedwe. Ma polima awa akuphatikizapo polyethylene glycol, polyvinyl acetate, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl cellulose ndi methyl cellulose. Zosakaniza zachilengedwe za polima monga chingamu cha mthethe, chingamu cha dzombe, chingamu cha dzombe, ndi zina zotero, zimakhalanso ndi kusakanikirana kwabwino. yankho lake. Hydroxypropyl methylcellulose imathanso kusakanizidwa ndi stearic acid kapena mannitol palmitate kapena sorbitol, komanso imatha kusakanizidwa ndi glycerin, sorbitol ndi mannitol. Mankhwalawa amatha kugwiritsidwa ntchito ngati hydroxypropyl methylcellulose plasticizers agent.

5. Hydroxypropyl methylcellulose sisungunuka m'madzi

Hydroxypropyl methylcellulose ndi yosasungunuka m'madzi osungunuka a cellulose ethers ndipo amatha kulumikizidwa pamwamba ndi ma aldehydes, zomwe zimapangitsa kuti ma ether osungunuka m'madziwa asungunuke m'madzi ndikukhala osasungunuka m'madzi. Ndipo kupanga hydroxypropyl methylcellulose insoluble mu aldehydes, formaldehyde, glyoxal, succinic acid, dialdehyde, etc. Mukamagwiritsa ntchito formaldehyde, chidwi chapadera chiyenera kuperekedwa ku pH ya yankho. Pakati pawo, glyoxal imachita mwachangu, chifukwa chake imagwiritsidwa ntchito m'makampani Glyoxal imagwiritsidwa ntchito ngati cholumikizira cholumikizira pakupanga. - Njira yolumikizirana. Mlingo wamtundu woterewu wolumikizana nawo mu yankho ndi 0.2% mpaka 10% ya misa ya ether, ndipo yabwino kwambiri ndi 7% mpaka 10%. Ngati glyoxal ikugwiritsidwa ntchito, 3.3% mpaka 6% ndiyoyenera kwambiri. Kutentha kwamankhwala ambiri ndi 0 ~ 30 ℃ ndipo nthawi ndi 1 ~ 120min. Kuphatikizika kolumikizana kuyenera kuchitika pansi pa acidic. Nthawi zambiri, asidi amphamvu kapena organic carboxylic acid amawonjezedwa ku yankho kuti asinthe pH ya yankho kukhala pafupifupi 2 mpaka 6, makamaka pakati pa 4 ndi 6, kenako ma aldehydes amawonjezedwa kuti achitepo kanthu. Ma acid omwe amagwiritsidwa ntchito ndi monga hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, glycolic acid, succinic acid kapena citric acid, omwe mwa omwe formic acid kapena acetic acid ndi abwino kwambiri, ndipo formic acid ndi yabwino kwambiri. Ma Acid ndi aldehydes amathanso kuwonjezeredwa nthawi imodzi kuti alumikizane ndi yankho mkati mwa pH yomwe mukufuna. Izi nthawi zambiri zimagwiritsidwa ntchito pomaliza njira yokonzekera cellulose ether kuti cellulose ether isasungunuke ndikuthandizira kutsuka ndi kuyeretsa ndi madzi a 20 ~ 25 ° C. Mukamagwiritsa ntchito mankhwalawa, mukhoza kuwonjezera zinthu zamchere ku mankhwala opangira mankhwala kuti musinthe pH ya yankho kuti ikhale yamchere kuti mankhwalawa asungunuke mwamsanga mu yankho. Njirayi ingagwiritsidwenso ntchito pamene filimu yakonzedwa pogwiritsa ntchito njira ya cellulose ether ndiyeno filimuyo imasinthidwa kukhala filimu yosasungunuka.

6. Hydroxypropyl methylcellulose anti-enzyme

Zochokera ku cellulose za hydroxypropyl methylcellulose zimatsutsana ndi ma enzymes. Mwachitsanzo, gulu lililonse la anhydroglucose limalumikizidwa mwamphamvu ndi gulu lolowa m'malo ndipo silingatengeke ndi kukokoloka kwa tizilombo komanso matenda. Komabe, kwenikweni, mtengo wolowa m'malo wa mankhwala omalizidwa umaposa 1. Ikhozanso kunyozedwa ndi michere, yomwe imasonyeza kuti mlingo wa kulowetsedwa kwa gulu lirilonse mu unyolo wa cellulose ndi wosagwirizana, ndipo tizilombo toyambitsa matenda tingathe kuwononga magulu a anhydroglucose omwe sali oyandikana nawo kuti apange. shuga, yomwe imatha kuyamwa ndi tizilombo toyambitsa matenda monga chakudya. Chifukwa chake, ngati kuchuluka kwa ether m'malo mwa cellulose kumawonjezeka, kukana kwa cellulose ethers kuukira kwa enzymatic kudzawonjezeka. Zimanenedwa kuti pansi pa zikhalidwe zolamulidwa, hydroxypropyl methylcellulose (DS = 1.9), methylcellulose (DS = 1.83), methylcellulose (DS = 1.66), hydroxyethylcellulose (1.7%) Ma viscosities otsalira ndi 13.2%, 7.3%, 3.7% ndi 1.8% motsatira. Hydroxypropyl methylcellulose ili ndi mphamvu zotsutsa ma enzyme. Zitha kuwoneka kuti hydroxypropyl methylcellulose imakhala ndi kukana kwa michere yabwino kwambiri, kuphatikiza ndi kubalalitsidwa kwake, kukhuthala ndi kupanga mafilimu, imatha kugwiritsidwa ntchito muzopaka za emulsion, ndi zina zambiri, ndipo nthawi zambiri sizifuna kuwonjezera zoteteza. Komabe, pofuna kupewa njira yothetsera kusungidwa kwa nthawi yaitali kapena kuipitsidwa kwa kunja, zosungirazo zikhoza kuwonjezeredwa, ndipo kusankha kosungirako kungapangidwe malinga ndi zofunikira zomaliza za yankho. Phenylmercuric acetate ndi manganese fluorosilicate ndi zoteteza, koma ndizowopsa ndipo ziyenera kusamaliridwa. Kawirikawiri, 1 mpaka 5 mg wa phenylmercuric acetate akhoza kuwonjezeredwa ku lita imodzi ya yankho.

7. Kuchita kwa hydroxypropyl methylcellulose membrane

Hydroxypropyl methylcellulose kupanga mafilimu Hydroxypropyl methylcellulose ali ndi zabwino kwambiri kupanga mafilimu. Pamene njira yake yamadzimadzi kapena organic zosungunulira zosungunulira yokutidwa pa galasi mbale, amakhala colorless, mandala ndi amphamvu filimu pambuyo kuyanika. . Ili ndi kukana kwabwino kwa chinyezi ndipo imakhalabe yolimba pa kutentha kwakukulu. Ngati mapulasitiki a hygroscopic awonjezeredwa, kutalika kwake ndi kusinthasintha kumatha kupitsidwanso, ndipo kusinthasintha kumatha kupitsidwanso. Plasticizers monga glycerol ndi sorbitol ndi oyenera kwambiri. Njira yothetsera vutoli ndi 2% ~ 3%, ndipo mlingo wa plasticizer ndi 10% ~ 20% ya cellulose ether. Ngati zinthu za plasticizer ziyenera kukhala zapamwamba, colloid syneresis imachitika pansi pa chinyezi chambiri. Mphamvu yolimba ya filimuyo yokhala ndi plasticizer yowonjezeredwa ndi yayikulu kuposa ya filimuyo popanda plasticizer, ndipo imawonjezeka ndi kuchuluka kwa pulasitiki yowonjezeredwa. The hygroscopicity ya filimuyi imawonjezekanso ndi kuchuluka kwa plasticizer.