Hydroxypropyl Methyl Cellulose HPMC

Hydroxypropyl methylcellulose(HPMC) ndi chochokera ku cellulose chomwe chimagwiritsidwa ntchito m'mafakitale osiyanasiyana, kuphatikiza mankhwala, chakudya, zomangamanga, komanso chisamaliro chamunthu. Amapangidwa ndi kusintha kwa cellulose kudzera mu etherification, komwe kumaphatikizapo kuyambitsa magulu a hydroxypropyl ndi methyl mu molekyulu ya cellulose.

HPMC ndi ufa wopanda fungo woyera mpaka woyera womwe umasungunuka m'madzi ndipo umapanga yankho lomveka bwino, lowoneka bwino. Lili ndi zinthu zosiyanasiyana zomwe zimapangitsa kuti zikhale zothandiza pazinthu zosiyanasiyana. Mwachitsanzo, ndi thickener, stabilizer, ndi emulsifier mu zakudya. Pomanga, amagwiritsidwa ntchito ngati chosungira madzi mu simenti ndi matope kuti azitha kugwira bwino ntchito komanso kupewa kusweka. M'zinthu zosamalira anthu, zimagwiritsidwa ntchito ngati thickener ndi emulsifier mu lotions, creams, ndi mankhwala ena.

Pazamankhwala, HPMC imagwiritsidwa ntchito ngati binder, disintegrant, and controlled-release agent m'mapiritsi ndi makapisozi. Amagwiritsidwanso ntchito ngati suspending wothandizira mu formulations madzi ndi monga lubricant mu mafuta ndi zonona. HPMC ndi chovomerezeka chovomerezeka mumakampani opanga mankhwala chifukwa cha biocompatibility, chitetezo, komanso kawopsedwe kakang'ono.

HPMC ili ndi magiredi angapo okhala ndi ma viscosity osiyanasiyana, omwe amasankhidwa ndi manambala. Kuchuluka kwa chiwerengerocho, kumapangitsanso kukhuthala. Magiredi a HPMC amachokera ku viscosity yochepa (5 cps) mpaka kukhuthala kwakukulu (100,000 cps). The mamasukidwe akayendedwe a HPMC ndi chinthu chofunika kudziwa katundu ndi ntchito.

Kugwiritsiridwa ntchito kwa HPMC muzamankhwala kwakula m'zaka zaposachedwa chifukwa cha kusinthasintha kwake komanso kufunikira kwa njira zatsopano zoperekera mankhwala. Ma hydrogel opangidwa ndi HPMC akhala akugwiritsidwa ntchito m'machitidwe operekera mankhwala chifukwa cha biocompatibility, kumasulidwa kwawo, komanso zinthu zomatira. Mapiritsi opangidwa ndi HPMC apangidwanso ndi zinthu zosinthidwa zomwe zimalola kuperekedwa kwa mankhwala omwe akutsata komanso kutsata bwino kwa odwala.

Komabe, HPMC ilibe malire ake. Ili ndi kusungunuka kosakwanira mu zosungunulira za organic ndipo imakhudzidwa ndi kusintha kwa pH. Kuonjezera apo, imakhala ndi kutentha kochepa ndipo imatha kutaya mamasukidwe ake pa kutentha kwakukulu. Zolepheretsa izi zapangitsa kuti pakhale zotuluka zina za cellulose, monga hydroxyethyl cellulose (HEC) ndi carboxymethyl cellulose (CMC), zomwe zasintha katundu ndi mitundu yochulukirapo yogwiritsira ntchito.

Pomaliza, HPMC ndiyochokera ku cellulose yosunthika yomwe imagwiritsidwa ntchito kwambiri m'mafakitale osiyanasiyana, makamaka m'zamankhwala. Makhalidwe ake apadera, kuphatikizapo biocompatibility, chitetezo, ndi kawopsedwe kakang'ono, zimapangitsa kuti ikhale yodziwika bwino pakupanga mankhwala. Njira zoperekera mankhwala zochokera ku HPMC zawonetsa kudalirika pakuwongolera magwiridwe antchito amankhwala komanso kutsata kwa odwala. Komabe, zoperewera zake pakusungunuka komanso kukhudzidwa kwa pH zapangitsa kuti zinthu zina zotumphukira za cellulose zikhale ndi zinthu zabwino.