HPMC imagwiritsa ntchito kupaka mapiritsi

mapiritsi ❖ kuyanika Nthawi zambiri amagwiritsidwa ntchito pokonzekera mawonekedwe olimba, malinga ndimapiritsi ❖ kuyanika zipangizo akhoza kugawidwa mu ufamapiritsi ❖ kuyanika, pansimapiritsi ❖ kuyanika, gawomapiritsi ❖ kuyanika, piritsimapiritsi ❖ kuyanika, kapisozimapiritsi ❖ kuyanika; Malinga ndimapiritsi ❖ kuyanika zipangizo amagawidwa shugamapiritsi ❖ kuyanika, half filmmapiritsi ❖ kuyanika,filimumapiritsi ❖ kuyanika (kutengera mitundu yosiyanasiyana ya zida za polima, kuphatikiza entericmapiritsi ❖ kuyanika), zinthu zapaderamapiritsi ❖ kuyanika (monga stearic acid, parafini, polysaccharide); Malinga ndimapiritsi ❖ kuyanika luso, akhoza kugawidwa mu kutsitsimapiritsi ❖ kuyanika, zipanimapiritsi ❖ kuyanika, kupanikizika koumamapiritsi ❖ kuyanika, electrostaticmapiritsi ❖ kuyanika ndi laminatingmapiritsi ❖ kuyanika. Pakati pawo, utsimapiritsi ❖ kuyanika ndi omwe amagwiritsidwa ntchito kwambiri. Mfundo yake ndi kupopera mbewu mankhwalawamapiritsi ❖ kuyanika madzi mu mitsinje nkhungu kuphimba pamwamba pa zipangizo (ufa, particles, mapiritsi). Ndipo mwamsanga ziume kupangamapiritsi ❖ kuyanika wosanjikiza: molingana ndimapiritsi ❖ kuyanika cholinga chagawidwa m'madzi sungunukamapiritsi ❖ kuyanika, m'mimba kusungunukamapiritsi ❖ kuyanika, osasungunukamapiritsi ❖ kuyanika, kumasulidwa pang'onopang'onomapiritsi ❖ kuyanika, entericmapiritsi ❖ kuyanika.

Udindo wamapiritsi ❖ kuyanika zikuphatikizapo: (1) chinyezi, kuwala, mpweya kudzipatula kuwonjezera kukhazikika kwa mankhwala; (2Kuphimba fungo loipa, kuchepetsa kukondoweza; (3) Sinthani mawonekedwe, osavuta kuzindikira; (4) Control mankhwala kumasulidwa malo, monga chapamimba madzi mosavuta kuwonongedwa kotero kuti amamasulidwa m'matumbo: (5) kulamulira kubalalika mankhwala, kumasula liwiro: (6) kugonjetsa zosagwirizana, etc.mapiritsi ❖ kuyanika zakuthupi ziyenera kukhala ndi zofunikira izi: zopanda poizoni, zopanda mankhwala, zokhazikika pakutentha, kuwala, madzi, mpweya, ndipo sizichitamapiritsi ❖ kuyanika mankhwala osokoneza bongo; (2) akhoza kusungunuka mu wogawana omwazika mu sing'anga kubalalitsidwa oyeneramapiritsi ❖ kuyanika: (3) akhoza kupanga mosalekeza, olimba, wosanjikiza yosalala, kukana ming'alu ndipo ali ndi madzi kudzipatula bwino, chinyezi kudzipatula, shading, mpweya permeability;④Kusungunuka kwake kuyenera kukwaniritsa zofunikira za - zokhazikika, nthawi zina siziyenera kukhudzidwa ndi PH, nthawi zina zimatha kusungunuka mumtundu wina wa PH. Mtundu wazinthu zomwe zili ndi mawonekedwe apamwamba nthawi imodzi siziwoneka kwambiri, chifukwa chake chimagwiritsidwa ntchito mosakanikiranamapiritsi ❖ kuyanika zinthu zambiri, kuti tiphunzire kwa wina ndi mzake.

Piritsimapiritsi ❖ kuyanika ndi yomwe imagwiritsidwa ntchito kwambiri, nthawi zambiri imagwiritsa ntchito mphikamapiritsi ❖ kuyanika ndi kukwiriridwa pipemapiritsi ❖ kuyanika (kuchita bwino kwambirimapiritsi ❖ kuyanika makinamapiritsi ❖ kuyanika), yotsirizirayo ndi yabwino kwa filimumapiritsi ❖ kuyanika. Bedi lamadzimadzimapiritsi ❖ kuyanika ndi oyenera kwambiri zipangizo ndi ang'onoang'ono tinthu kukula monga pellets ndi ufa. Poyerekeza ndi shugamapiritsi ❖ kuyanika,filimumapiritsi ❖ kuyanika ali ndi ubwino wambiri 1)Kufupikitsa nthawi ndikuchepetsa mtengo wazinthu; (2) palibe kuwonjezeka kwambiri kulemera: (3) palibe chifukwa cha pansi wosanjikiza: (4) amphamvu, kuphwanya ndi akulimbana kukana: (5) akhoza kusindikizidwa, komanso sizimakhudza Chip lettering;(6) Itha kuteteza bwino mankhwalawa ku mphamvu ya kuwala, mpweya ndi madzi; (7) Palibe vuto pa nthawi ya kupasuka 8) kukongoletsa kwazinthu 9) imapereka mwayi wogwiritsa ntchito madzi osagwiritsa ntchito madzimapiritsi ❖ kuyanika; Njira ndi zipangizo zikhoza kukhala zovomerezeka. Tsopano chitukuko cha mankhwala atsopanomapiritsi ❖ kuyanika kukonzekera nthawi zambiri kumatenga filimumapiritsi ❖ kuyanika,filimumapiritsi ❖ kuyanika mankhwala ofunikira amaphatikizapo kupanga mafilimu (mapiritsi ❖ kuyanika zakuthupi), zosungunulira, plasticizer, colorant, amathanso kuwonjezera pore-oyambitsa wothandizira, insoluble filler, etc..mapiritsi ❖ kuyanika mankhwala ndi chinsinsi cha kupambana kwamapiritsi ❖ kuyanika. Pakali pano, filimu yosungunuka ndi madzimapiritsi ❖ kuyanika Zomwe zimagwiritsidwa ntchito nthawi zambiri ndi monga hydroxypropyl methyl cellulose (HPMC) ndi hydroxypropyl cellulose (HPC). Polyethylene glycol (PEG), polyethylene pyrrolidone (PVP), zinthu zosungunuka za enteric kuphatikizapo enteric-soluble acrylic resin, hydroxypropyl methyl cellulose phthalate (HPMCP). Cellulose acetate phthalate ester (CAP). Shellac, zinthu zosasungunuka zimaphatikizapo ethyl cellulose (EC), zein.

Kwa zaka zambiri, filimumapiritsi ❖ kuyanika wapita patsogolo kwambiri. Mulingo wachikhalidwemapiritsi ❖ kuyanika kugwiritsa ntchito ndondomekoMtengo wa HPMC(hydroxypropyl methylcellulose) monga polima wamkulu, womwe umagwiritsidwabe ntchito kwambiri masiku ano. HPMC-zokhazikikamapiritsi ❖ kuyanika machitidwe amapereka ntchito yokwanira, koma pali malo oti asinthe. Mtengo wa HPMCmapiritsi ❖ kuyanika filimu mwina kutsatira piritsi bwino, nthawi zambiri yaitalimapiritsi ❖ kuyanika nthawi, zomwe zimapangitsa kupanga pang'onopang'ono. Kuyamba kotsatira kwaPVA yokhazikika mapiritsi ❖ kuyanika machitidwe apititsa patsogolo magwiridwe antchito, zomwe zimapangitsa kuti zikhale bwinomapiritsi ❖ kuyanika magwiridwe antchito komanso kupanga mwachangu, zomwe zikutanthauza kuti zolakwika sizingachitike m'mapiritsi.

Pamene mamasukidwe akayendedwe a HPMC akuwonjezeka, mphamvu ya filimu yopangidwa ndi HPMC imawonjezeka mofanana, ndipo potsirizira pake imafika ku mphamvu yaikulu ya filimuyi sikuwonjezekanso ndi kuwonjezeka kwa kukhuthala kwa HPMC.

Mumapiritsi ❖ kuyanika, kuti akwaniritse bwino kwambirimapiritsi ❖ kuyanika, nthawi zambiri kusinthamapiritsi ❖ kuyanika madzi olimba okhutira, zomwe zidzatsogolera kumapiritsi ❖ kuyanika kukhuthala kwamadzimadzi ndipamwamba kwambiri, kusankha otsika mamasukidwe akayendedwe HPMC angathe kuthetsa vutoli, koma kutsogolera filimu mphamvu amakhudzidwa. Kuti athetse mavuto awa amapasa, kusakaniza ma polima kwakhala chida chodziwika bwino.

MongaMtengo wa HPMCE15 zili pang'onopang'ono kumawonjezera, kukhuthala kwa kusakaniza kwaMtengo wa HPMCe5 ndiMtengo wa HPMCE15 imakulanso pang'onopang'ono.

Mu shugamapiritsi ❖ kuyanika, tachokanso kuchokera ku luso kupita ku sayansi. Zopangidwa ndi shuga zimakhala zokometsera chifukwa zimakhala zosalala, zonyezimira, zotsekemera zomwe zimabisa zowawa. Koma zovuta zazikulu mu shugamapiritsi ❖ kuyanika gona pakupanga ndi kubereka. Shugamapiritsi ❖ kuyanika Ndi ntchito yolemetsa komanso yowononga nthawi ndipo imatha kusiyanasiyana kutengera ndi munthu amene akuchitamapiritsi ❖ kuyanika.