HPMC ntchito madontho diso

Hydroxypropyl methylcellulose (HPMC) ndi polima omwe amagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, makamaka popanga mankhwala opangidwa ndi ophthalmic monga madontho a m'maso. Madontho a m'maso amagwiritsidwa ntchito pochiza matenda osiyanasiyana monga diso louma, glaucoma, ndi chifuwa. HPMC angagwiritsidwe ntchito madontho diso monga mamasukidwe akayendedwe-ubwino wothandizila, mucoadhesive wothandizila, ndi wothandizila zoteteza. M'nkhaniyi, tiona kugwiritsa ntchito HPMC mu madontho a maso mwatsatanetsatane.

Viscosity-ennhance agent

Imodzi mwamaudindo akuluakulu a HPMC m'madontho amaso ndikukulitsa kukhuthala kwawo. Viscosity ndi gawo lofunika kwambiri pakupanga mawonekedwe a ophthalmic chifukwa limathandiza kuonetsetsa kuti mapangidwewo amakhalabe pamtunda wokwanira kuti apereke chithandizo chamankhwala. Kukhuthala kwa mayankho a HPMC kumadalira kuchuluka kwa maselo a polima komanso kuchuluka kwa m'malo. Mayankho a HPMC okhala ndi kulemera kwakukulu kwa maselo ndi digiri ya m'malo amakhala ndi mamasukidwe apamwamba.

HPMC ndi yabwino kwambiri mamasukidwe akayendedwe owonjezera kwa madontho m'maso monga amapereka mosalekeza-kumasulidwa zotsatira chifukwa gel osakaniza katundu. Gel opangidwa ndi HPMC m'madontho a m'maso amatalikitsa nthawi yolumikizana pakati pa mankhwalawa ndi diso, motero amawongolera mphamvu ya mankhwalawa. Kuphatikiza apo, mayankho a HPMC sasokoneza masomphenya, kuwapangitsa kukhala njira yabwino yodontha m'maso.

Mucoadhesive wothandizira

Ntchito ina yofunika kwambiri ya HPMC mu madontho a maso ndi mawonekedwe ake omatira. HPMC ali mkulu kuyanjana kwa nembanemba ntchofu, ndi ntchito yake madontho diso angathandize kutalikitsa okhala nthawi ya chiphunzitso pa ocular padziko. Izi ndizopindulitsa makamaka pochiza matenda a maso owuma, kumene kuwonetseredwa kwa nthawi yayitali kungathandize kuchepetsa zizindikiro za kuuma ndi kusamva bwino.

The mucoadhesive katundu wa HPMC amachokera ku mgwirizano wake wa haidrojeni wolumikizana ndi mucin glycoproteins. Mucin glycoproteins ndi zigawo zikuluzikulu za ocular pamwamba ntchofu wosanjikiza, amene amagwira ntchito ngati chotchinga zoteteza. HPMC akhoza kutsatira ntchofu wosanjikiza ndi kuwonjezera kukhudzana nthawi ya chiphunzitso pa ocular padziko.

Wothandizira chitetezo

Kuphatikiza pa kukhathamiritsa kwamphamvu komanso kumatira kwa mucoadhesive, HPMC imagwiritsidwanso ntchito ngati choteteza m'madontho amaso. Mawonekedwe akunja amatha kuwonongeka ndi zinthu zakunja monga kuwala kwa UV, kuipitsidwa, ndi mpweya wouma. HPMC ikhoza kupanga filimu yoteteza pamwamba pa ocular yomwe ingathandize kuteteza maso kuzinthu zovulaza izi.

The zoteteza katundu HPMC ndi chifukwa mapangidwe gel osakaniza wosanjikiza pa ocular pamwamba. Chigawochi chimagwira ntchito ngati chotchinga chakuthupi chomwe chingathandize kupewa kulowa kwa zinthu zovulaza m'maso. HPMC ingathandizenso kuchepetsa mawonekedwe a ocular komanso kuchepetsa zizindikiro za mkwiyo wa ocular.

Mapeto

Pomaliza, HPMC ndi polima yosunthika yomwe imagwiritsa ntchito kwambiri popanga mankhwala opangidwa ndi ophthalmic, makamaka madontho a m'maso. HPMC akhoza kusintha mamasukidwe akayendedwe a madontho diso, amene angathandize kutalikitsa kukhudzana nthawi ndi ocular pamwamba ndi kusintha lachangu awo. HPMC a mucoadhesive katundu angathandize kukulitsa mukukhala nthawi ya chiphunzitso pa ocular padziko, kupanga njira yabwino kuchiza youma diso syndrome. HPMC akhoza kuteteza pamwamba ocular ku zinthu zoipa kunja ndi kupanga wosanjikiza zoteteza. Kusankha mosamala giredi yoyenera ya HPMC ndi kuyika kwake kungathandize kuwonetsetsa kuti magwiridwe antchito ndi ogwirizana pamapangidwe otsitsa maso.