HPMC mu Pharmaceuticals

The pharmaceutical excipient hydroxypropyl methyl cellulose (HPMC) ndi non-ionic cellulose ether excipients, panopa ndi yaikulu ntchito kunyumba ndi kunja kwa mankhwala excipients - a, monga excipient mankhwala ali ndi zaka zoposa 30 mbiri. Ndi odorless, zoipa, sanali poizoni, sungunuka m'madzi ozizira, gelation m'madzi otentha, otsika mamasukidwe akayende mlingo HPMC angagwiritsidwe ntchito ngati zomatira, kukakamira wothandizila ndi kuyimitsidwa wothandizila mkulu mamasukidwe akayendedwe mlingo HPMC angagwiritsidwe ntchito pokonzekera osakaniza chimango chimango zosakaniza-kumasulidwa. mapiritsi, makapisozi omasulidwa mosalekeza, hydrophilic gel framework blocker-release-release tablets blocker, controller release agent ndi pore channel agent.

Zothandizira pamankhwala zimatanthawuza zowonjezera ndi zowonjezera zomwe zimagwiritsidwa ntchito popanga ndi kugawa mankhwala. Chinthu, kupatulapo chogwiritsidwa ntchito, chomwe chawunikidwa bwino kuti chitetezeke ndipo chimaphatikizidwa mu mankhwala. Othandizira mankhwala ali ndi ntchito zofunika kwambiri zosungunulira, kuthandizira kusungunuka, kumasulidwa kwapang'onopang'ono komanso kolamuliridwa kuwonjezera pa kupanga, kudzaza zonyamulira ndi kukonzanso kukhazikika, zomwe zingakhudze ubwino, chitetezo ndi mphamvu ya mankhwala.

Hydroxypropyl methyl cellulose HPMC ndi imodzi mwazinthu zazikulu zothandizira mankhwala kunyumba ndi kunja, zomwe zakhala zikugwiritsidwa ntchito ngati mankhwala kwa zaka zambiri. Ndiwopanda fungo, wosakoma komanso wopanda poizoni, wosungunuka m'madzi ozizira ndi gelatinous m'madzi otentha. HPMC monga zachilengedwe hydrophilic polima mankhwala wothandiza zipangizo, osati angagwiritsidwe ntchito monga piritsi, granule, mapiritsi zomatira ndi disintegrant, filimu ❖ kuyanika zakuthupi, angagwiritsidwenso ntchito ngati wothandizira colloidal ndi kuyimitsidwa wothandizira, kumasulidwa pang'onopang'ono ndi kulamulidwa kumasulidwa kukonzekera blocker, ankalamulira. kumasula wothandizila ndi pore-kupanga wothandizira, komanso chonyamulira cha kubalalitsidwa olimba.

HPMC monga binder ndi disintegrating wothandizira. HPMC monga binder akhoza kuchepetsa kukhudzana Ngodya mankhwala, kuti mankhwala mosavuta kunyowa, ndi madzi ake akhoza kuwonjezera mazana nthawi, kotero akhoza kwambiri kusintha kuvunda kapena kumasulidwa kwa mapiritsi. HPMC ali amphamvu mamasukidwe akayendedwe, pakuti kapangidwe ka khirisipi kapena Chimaona zovuta zopangira akhoza kumapangitsanso tinthu mamasukidwe akayendedwe ake, kusintha compressibility ake. HPMC otsika mamasukidwe akayendedwe angagwiritsidwe ntchito ngati binder ndi disintegrating wothandizira, mkulu mamasukidwe akayendedwe kokha ngati binder, ndalama zimasiyanasiyana malinga ndi chitsanzo ndi zofunika, ndalama ambiri ndi 2% -5%.

HPMC ntchito ngati ankalamulira kumasulidwa zakuthupi kukonzekera pakamwa. HPMC ndi chimango cha hydrogel chomwe chimagwiritsidwa ntchito pokonzekera kumasulidwa kosalekeza. HPMC yokhala ndi kukhuthala kotsika (5 ~ 50mPa • s) itha kugwiritsidwa ntchito ngati binder, zomatira-zowonjezera wothandizira komanso kuyimitsidwa, pomwe HPMC yokhala ndi kukhuthala kwapamwamba (4000 ~ 100000mPa • s) ingagwiritsidwe ntchito pokonzekera kumasulidwa kwazinthu zosakanikirana. mapiritsi, makapisozi omasulidwa, hydrophilic gel framework mapiritsi otulutsidwa ngati blocker. HPMC akhoza kusungunuka mu chapamimba enteric madzimadzi, ali ndi ubwino pressability wabwino, fluidity, wamphamvu mankhwala Mumakonda luso ndi mankhwala kumasulidwa makhalidwe sakukhudzidwa ndi pH, etc., ndi yofunika kwambiri hydrophilic chonyamulira zinthu mu kupitiriza kumasulidwa dongosolo kukonzekera, ambiri. amagwiritsidwa ntchito ngati chimango cha hydrophilic gel ndi zokutira pokonzekera kumasulidwa kosalekeza, ndipo amagwiritsidwa ntchito pokonzekera chapamimba choyandama, chothandizira kutulutsa filimu yotulutsa mankhwala.

HPMC ngati wothandizira kupanga filimu. HPMC ali wabwino kupanga filimu, ndipamene mandala filimu, amphamvu, kupanga si kophweka n'kudziphatika, makamaka mosavuta mayamwidwe chinyezi, wosakhazikika mankhwala, ndi izo monga kudzipatula wosanjikiza akhoza kwambiri patsogolo bata la mankhwala, kupewa filimu mabala. Poyerekeza ndi mapangidwe a filimu ya gelatin, filimu ya HPMC ili ndi mawonekedwe abwino komanso kufalikira kwa kuwala. HPMC ali zosiyanasiyana specifications mamasukidwe akayendedwe, kusankha koyenera, ❖ kuyanika khalidwe, maonekedwe ndi bwino kuposa kugwiritsa ntchito zipangizo zina, ambiri ntchito ndende yake 2% -10%.

HPMC ngati wothandizira kuyimitsidwa. Inayimitsidwa madzi kukonzekera ambiri ntchito matenda mlingo mitundu, amene ndi heterogeneous kupezeka kachitidwe insoluble olimba mankhwala mu madzi kubalalitsidwa TV. Kukhazikika kwa dongosolo kumatsimikizira ubwino wa kukonzekera kwamadzi oimitsidwa. HPMC colloidal njira akhoza kuchepetsa olimba-zamadzimadzi mawonekedwe mikangano, kuchepetsa padziko ufulu mphamvu ya particles olimba, kuti sakanikira kubalalitsidwa dongosolo amakhala okhazikika, ndi kwambiri kuyimitsidwa wothandizira. HPMC ntchito monga thickener kwa madontho diso, ndi zili 0.45% -1.0%.