HPMC kwa Chowona Zanyama

Hydroxypropyl methylcellulose (HPMC) ndi polima yomwe imagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, ndipo imagwiritsidwanso ntchito popanga mankhwala azinyama. HPMC ndi madzi osungunuka, osakhala a ionic cellulose ether omwe amachokera ku cellulose yachilengedwe. Ndi polima yotetezeka, yogwirizana ndi biodegradable polima yomwe imagwiritsidwa ntchito kupititsa patsogolo kukhazikika, mawonekedwe a rheological, ndi bioavailability wamankhwala azinyama. M'nkhaniyi, tikambirana za katundu ndi ntchito HPMC mankhwala Chowona Zanyama.

Katundu wa HPMC

HPMC ndi theka-kupanga polima kuti limachokera mapadi. Ili ndi zinthu zingapo zomwe zimapangitsa kuti ikhale yoyenera kugwiritsidwa ntchito pazanyama. Zinthu izi zikuphatikizapo:

Kusungunuka kwamadzi: HPMC imasungunuka kwambiri m'madzi, zomwe zikutanthauza kuti imatha kusungunuka m'madzi ndi njira zina zamadzimadzi. Izi zimapangitsa kuti zikhale zosavuta kuphatikiza mankhwala azinyama.

Khalidwe labodza lapulasitiki: HPMC imawonetsa khalidwe lapulasitiki lachinyengo, zomwe zikutanthauza kuti ndi thixotropic komanso kumeta ubweya. Katunduyu amalola kuchepetsa mamasukidwe akayendedwe a kuyimitsidwa pamene akukhudzidwa ndi kukameta ubweya wa ubweya, zomwe zimapangitsa kuti zikhale zosavuta kupereka mankhwala a Chowona Zanyama.

Kuthekera kopanga filimu: HPMC ili ndi luso lopanga filimu, zomwe zikutanthauza kuti imatha kupanga chinsalu chotetezera pamwamba pa tinthu tating'onoting'ono tamankhwala a Chowona Zanyama, zomwe zimawathandiza kuti asawonongeke ndi kuphatikizika.

Mucoadhesive katundu: HPMC ali mucoadhesive katundu, kutanthauza kuti akhoza kumamatira pa mucosal pamwamba pa thupi. Katunduyu ndiwothandiza makamaka pamachitidwe operekera mankhwala amkamwa ndi m'mphuno, chifukwa amalola nthawi yayitali yolumikizana ndi malo a mucosal komanso kuyamwa bwino kwa mankhwala.

Kugwiritsa Ntchito HPMC mu Veterinary Medicine

HPMC imagwiritsidwa ntchito pamankhwala osiyanasiyana azinyama. Zina mwazinthu zomwe zimagwiritsidwa ntchito kwambiri ndi HPMC pazamankhwala azinyama ndi:

Kukhazikika: HPMC imagwiritsidwa ntchito kukonza kukhazikika kwamankhwala azinyama. Zingathandize kupewa tinthu aggregation, flocculation, ndi sedimentation, amene akhoza kusintha alumali moyo wa mankhwala.

Rheological kusinthidwa: HPMC angagwiritsidwe ntchito kusintha rheological katundu wa Chowona Zanyama mankhwala. Zingathandize kuchepetsa mamasukidwe akayendedwe a mankhwala, zomwe zingapangitse kuti zikhale zosavuta kupereka.

Kutulutsidwa kolamuliridwa: HPMC itha kugwiritsidwa ntchito kukwaniritsa kumasulidwa kwamankhwala kuchokera kumankhwala azinyama. Kuthekera kopanga filimu kwa HPMC kumapangitsa kuti pakhale chinsalu choteteza pamwamba pa tinthu tating'onoting'ono ta mankhwala, chomwe chingachepetse kutulutsidwa kwa mankhwalawa m'thupi.

Kuwongoleredwa kwa Bioavailability: HPMC imatha kupititsa patsogolo kupezeka kwamankhwala mumankhwala azinyama. The mucoadhesive zimatha HPMC kulola kumamatira mucosal pamwamba pa thupi, amene akhoza kusintha mayamwidwe mankhwala ndi bioavailability.

Kulawa masking: HPMC angagwiritsidwe ntchito kubisa kukoma kosasangalatsa kwa mankhwala a Chowona Zanyama mankhwala. Izi ndizothandiza makamaka pakupanga pakamwa, chifukwa zimatha kupangitsa kuti mankhwalawa akhale okoma komanso osavuta kupereka kwa nyama.

Mapangidwe apamutu: HPMC imagwiritsidwanso ntchito muzolemba zam'mutu zamankhwala zamankhwala. Itha kugwiritsidwa ntchito ngati thickener, stabilizer, ndi emulsifier mu zonona, mafuta odzola, ndi ma gels. Khalidwe la pseudo-pulasitiki la HPMC limalola kuti izi zitheke kufalikira komanso kusasinthika kwa kapangidwe ka mitu.

Ma jakisoni: HPMC itha kugwiritsidwanso ntchito ngati jekeseni wamankhwala azinyama. Itha kugwiritsidwa ntchito ngati kuyimitsidwa wothandizira ndi mamasukidwe akayendedwe owongolera kuti apititse patsogolo kukhazikika komanso rheological katundu wa jekeseni.

Mapeto

Pomaliza, HPMC ndi polima yosunthika yomwe imagwiritsidwa ntchito kwambiri m'makampani azamankhwala, kuphatikiza zamankhwala azinyama. Kusungunuka kwake m'madzi, khalidwe la pulasitiki lachinyengo, luso lopanga mafilimu, zinthu zomatira mucoadhesive, ndi luso lophimba nkhope zimapangitsa kuti likhale lofunika kwambiri popanga mankhwala a Chowona Zanyama. HPMC akhoza kusintha bata, rheological katundu, bioavailability, ndi palatability wa Chowona Zanyama mankhwala, kuwapangitsa kukhala kosavuta kupereka ndi ogwira ntchito kuchiza nyama.