Momwe mungakwaniritsire kuchuluka kwa HPMC mu zokutira piritsi?

Kupititsa patsogolo chiwerengero cha mapangidwe a HPMC mu zokutira piritsi ndi njira yovuta yomwe imaphatikizapo kumvetsetsa thupi ndi mankhwala a HPMC ndi momwe mungakwaniritsire ntchito yophimba yomwe mukufunayo posintha mapangidwe.

Sankhani yoyenera HPMC mamasukidwe akayendedwe specifications: HPMC ali zosiyanasiyana kukhuthala makulidwe. HPMC yokhala ndi ma viscosity osiyanasiyana idzakhudza zomwe zili zolimba komanso zopanga filimu zokutira. Low mamasukidwe akayendedwe HPMC kumathandiza kuonjezera zolimba zili, koma angafunike pamodzi ndi sukulu zina za HPMC kutenga mwayi katundu wawo osiyana thupi.

Gwiritsani ntchito mitundu ingapo ya HPMC: M'njira zokongoletsedwa, ma HPMC angapo amitundu yosiyanasiyana amagwiritsidwa ntchito nthawi imodzi kuti agwiritse ntchito bwino mawonekedwe awo osiyanasiyana. Kuphatikiza uku kumapangitsa kuti zokutira bwino komanso zabwino.

Kuwonjezera ma plasticizers: Plasticizers monga polyethylene glycol (PEG), triethyl citrate, etc. amatha kusintha kusinthasintha kwa filimuyo ndikuchepetsa kutentha kwa galasi (Tg), potero kumapangitsa kuti thupi likhale lopaka.

Ganizirani kuchuluka kwa yankho la zokutira: Zomwe zili zolimba za yankho la zokutira zimakhudza kwambiri pakuyala bwino. Kupaka madzi okhala ndi zinthu zolimba kumatha kuchepetsa nthawi yokutira ndikuwongolera kupanga bwino. Mwachitsanzo, mukamagwiritsa ntchito zida zochokera ku Kollicoat® IR, kuchuluka kwa makonzedwe opaka kumatha kufika 30%.

Konzani magawo opangira ❖ kuyanika: Magawo ophikira, monga kuchuluka kwa kupopera, kutentha kwa mpweya wolowera, kutentha kwa mphika, kuthamanga kwa atomization, komanso kuthamanga kwa mphika, kumakhudza mtundu wa ❖ kuyanika komanso kufanana. Mwa kusintha magawowa, zotsatira zabwino zokutira zitha kukwaniritsidwa.

Kugwiritsira ntchito HPMC yatsopano yotsika kwambiri ya maselo: Kulemera kwa maselo atsopano a HPMC (monga hypromellose 2906, VLV hypromellose) kungapangitse ndondomeko yokutira piritsi ndikuchepetsa ndalama. Pophatikizana ndi HPMC wamba, zokutira moyenera zitha kupezeka mu zokutira zapamwamba kwambiri, popanda zomata pansi pamikhalidwe yocheperako, komanso zokutira zamakanema zolimba.

Ganizirani za kukhazikika kwa zinthu zokutira: HPMCP ndi polima yokhazikika kwambiri yomwe kukhazikika kwake kumasungidwa pansi pa chinyezi chambiri, zomwe ndizofunikira kwambiri kuti mapiritsi okutidwa akhale abwino posungira.

Sinthani njira yokonzekera yothetsera ❖ kuyanika: Pankhani yokonzekera mwachindunji zosungunulira zosakaniza, pang'onopang'ono yonjezerani ufa wa HPMCP ku zosungunulira zosakaniza kuti mupewe mapangidwe a agglomerates. Zosakaniza zina muzitsulo zokutira monga plasticizers, pigment ndi talc ziyenera kuwonjezeredwa pakufunika.

Ganizirani za mankhwala: Kusungunuka ndi kukhazikika kwa mankhwalawa kudzakhudza kusankha kwa mapangidwe a ❖ kuyanika. Mwachitsanzo, pamankhwala opangira zithunzi, ma opacifiers angafunike kuteteza mankhwalawa kuti asawonongeke.

Chitani maphunziro owunikira komanso kukhazikika kwa in vitro: Kupyolera mu kuyesa kwa in vitro dissolution ndi kukhazikika, magwiridwe antchito a mapiritsi okutidwa amatha kuwunikidwa kuti zitsimikizire kugwira ntchito ndi kukhazikika kwa fomula yakuphimba pakugwiritsa ntchito.

Poganizira mozama zomwe zili pamwambazi ndikusintha molingana ndi momwe amapangidwira komanso mawonekedwe amankhwala, chiŵerengero cha HPMC mu zokutira piritsi chikhoza kukonzedwa kuti chikwaniritse bwino, chofanana komanso chokhazikika.