Hydroxyethyl Cellulose (HEC) ndi ma cellulose ethers (monga hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), hydroxypropyl cellulose (HPC) ndi carboxymethyl cellulose (CMC)) ndi ma polima ambiri omwe amagwiritsidwa ntchito kwambiri m'makampani, zomangamanga, zamankhwala, chakudya komanso tsiku lililonse. mafakitale a mankhwala. Ma cellulose awa amapangidwa ndi cellulose yosintha mankhwala ndipo amakhala ndi madzi abwino kusungunuka, kukhuthala, kukhazikika komanso kupanga mafilimu.
1. Hydroxyethyl Cellulose (HEC)
1.1 Kapangidwe ka Mankhwala ndi Katundu
Hydroxyethyl Cellulose (HEC) amapangidwa ndi hydroxyethylation wa mapadi ndi ethylene okusayidi pansi pa zinthu zamchere. Mapangidwe oyambira a HEC ndi mgwirizano wa ether wopangidwa ndi kusinthidwa kwa gulu la hydroxyl mu molekyulu ya cellulose ndi gulu la hydroxyethyl. Izi zimapatsa HEC katundu wapadera:
Kusungunuka kwamadzi: HEC imasungunuka m'madzi ozizira komanso otentha kuti apange njira yowonekera ya colloidal.
Kukhuthala: HEC ili ndi zinthu zabwino kwambiri zokometsera ndipo imagwiritsidwa ntchito kwambiri pamapulogalamu omwe amafunikira kuwongolera kukhuthala.
Kukhazikika: Yankho la HEC lili ndi kukhazikika kwakukulu mumitundu yosiyanasiyana ya pH.
Biocompatibility: HEC ndi yopanda poizoni, yosakwiyitsa, komanso yochezeka kwa thupi la munthu komanso chilengedwe.
1.2 Minda yofunsira
Zipangizo zomangira: zimagwiritsidwa ntchito ngati zokhuthala ndi zosungira madzi popangira matope a simenti ndi zinthu za gypsum.
Zopaka ndi utoto: zimagwiritsidwa ntchito ngati thickener, suspending agent ndi stabilizer.
Mankhwala atsiku ndi tsiku: amagwiritsidwa ntchito ngati zonenepa pazofunikira zatsiku ndi tsiku monga zotsukira ndi shampu.
Pharmaceutical munda: ntchito zomatira, thickener ndi suspending wothandizira mapiritsi mankhwala.
1.3 Ubwino ndi kuipa kwake
Ubwino: kusungunuka kwamadzi bwino, kukhazikika kwamankhwala, kusinthasintha kwa pH yayikulu komanso kusakhala kawopsedwe.
Zoipa: kusungunuka kosakwanira mu zosungunulira zina, ndipo mtengo ukhoza kukhala wokwera pang'ono kuposa ma ether ena a cellulose.
2. Kuyerekeza ma cellulose ethers ena
2.1 Hydroxypropyl methylcellulose (HPMC)
2.1.1 Kapangidwe ka mankhwala ndi katundu
HPMC imapangidwa kuchokera ku cellulose kudzera mu methylation ndi hydroxypropylation reactions. Mapangidwe ake ali ndi methoxy (-OCH3) ndi hydroxypropoxy (-OCH2CH (OH) CH3) m'malo.
Kusungunuka kwamadzi: HPMC imasungunuka m'madzi ozizira kuti ipange njira yowonekera ya colloidal; imakhala yosasungunuka bwino m'madzi otentha.
Kukhuthala katundu: Kuli ndi mphamvu yokhuthala kwambiri.
Ma gelling properties: Amapanga gel akatenthedwa ndipo amabwereranso momwe analili atakhazikika.
2.1.2 Magawo ofunsira
Zipangizo zomangira: Zimagwiritsidwa ntchito ngati zokhuthala ndi kusunga madzi popangira zinthu zopangidwa ndi simenti komanso gypsum.
Chakudya: Amagwiritsidwa ntchito ngati emulsifier ndi stabilizer.
Mankhwala: Amagwiritsidwa ntchito ngati chothandizira makapisozi amankhwala ndi mapiritsi.
2.1.3 Ubwino ndi kuipa kwake
Ubwino: Kukhuthala kwabwino komanso mawonekedwe a gelling.
Zoipa: Zimakhudzidwa ndi kutentha ndipo zimatha kulephera kugwiritsa ntchito kutentha kwakukulu.
2.2 Methyl cellulose (MC)
2.2.1 Kapangidwe ka mankhwala ndi katundu
MC imapezedwa ndi methylation ya cellulose ndipo makamaka imakhala ndi methoxy (-OCH3) m'malo.
Kusungunuka kwamadzi: Amasungunuka bwino m'madzi ozizira kuti apange njira yowonekera ya colloidal.
Kukhuthala: Kumakhala ndi kukhuthala kwakukulu.
Thermal gelation: imapanga gel ikatenthedwa ndikutsitsa ikazizira.
2.2.2 Magawo ofunsira
Zipangizo zomangira: zimagwiritsidwa ntchito ngati chokhuthala komanso chosungira madzi pamatope ndi utoto.
Chakudya: chimagwiritsidwa ntchito ngati emulsifier ndi stabilizer.
2.2.3 Ubwino ndi kuipa kwake
Ubwino: amphamvu thickening luso, nthawi zambiri ntchito ozizira processing luso.
Zoipa: kutentha kosamva kutentha, sikungagwiritsidwe ntchito pa kutentha kwakukulu.
2.3 Hydroxypropyl cellulose (HPC)
2.3.1 Kapangidwe ka mankhwala ndi katundu
HPC imapezeka ndi cellulose ya hydroxypropyl. Mapangidwe ake ali ndi hydroxypropoxy (-OCH2CH(OH)CH3).
Kusungunuka kwamadzi: kusungunuka m'madzi ozizira ndi organic solvents.
Kunenepa: Kuchita bwino kwa makulidwe.
Katundu wopanga mafilimu: amapanga filimu yolimba.
2.3.2 Minda yofunsira
Mankhwala: amagwiritsidwa ntchito ngati ❖ kuyanika zinthu ndi piritsi excipient mankhwala.
Chakudya: chimagwiritsidwa ntchito ngati thickener ndi stabilizer.
2.3.3 Ubwino ndi kuipa kwake
Ubwino: kusungunuka kwamitundu yambiri komanso kupanga mafilimu abwino kwambiri.
Zoipa: mtengo wapamwamba.
2.4 Carboxymethyl cellulose (CMC)
2.4.1 Kapangidwe ka mankhwala ndi mawonekedwe
CMC imapangidwa pochita ma cellulose ndi chloroacetic acid, ndipo imakhala ndi gulu la carboxymethyl (-CH2COOH) mu kapangidwe kake.
Kusungunuka kwamadzi: kusungunuka m'madzi ozizira ndi madzi otentha.
Kukhuthala katundu: kwambiri thickening zotsatira.
Ionicity: ndi anionic cellulose ether.
2.4.2 Minda yofunsira
Chakudya: chimagwiritsidwa ntchito ngati thickener ndi stabilizer.
Mankhwala atsiku ndi tsiku: amagwiritsidwa ntchito ngati chotupitsa chotsukira.
Kupanga mapepala: kumagwiritsidwa ntchito ngati chowonjezera pakukuta mapepala.
2.4.3 Ubwino ndi kuipa kwake
Ubwino: kukhuthala kwabwino komanso minda yayikulu yogwiritsira ntchito.
Zoyipa: kukhudzidwa ndi ma electrolyte, ma ion mu yankho angakhudze magwiridwe antchito.
3. Kuyerekeza kwathunthu
3.1 Kuchulukitsa magwiridwe antchito
HEC ndi HPMC ali ndi magwiridwe antchito ofanana ndipo onse amakhala ndi kukhuthala kwabwino. Komabe, HEC ili ndi kusungunuka kwamadzi kwabwinoko ndipo ndiyoyenera kugwiritsa ntchito zomwe zimafuna kuwonekera komanso kupsa mtima pang'ono. HPMC ndi zothandiza kwambiri ntchito zimene amafuna kutentha kwa gel osakaniza chifukwa katundu wake thermogel.
3.2 Kusungunuka kwamadzi
HEC ndi CMC zonse zimatha kusungunuka m'madzi ozizira komanso otentha, pomwe HPMC ndi MC zimasungunuka m'madzi ozizira. HPC imakondedwa pakafunika kugwirizana kwa zosungunulira zambiri.
3.3 Mtengo ndi mtundu wa ntchito
HEC nthawi zambiri imakhala yamtengo wapatali komanso imagwiritsidwa ntchito kwambiri. Ngakhale HPC imagwira ntchito bwino kwambiri, nthawi zambiri imagwiritsidwa ntchito pamapulogalamu omwe amafunidwa kwambiri chifukwa cha kukwera mtengo kwake. CMC ili ndi malo pamapulogalamu ambiri otsika mtengo ndi mtengo wake wotsika komanso magwiridwe antchito abwino.
Hydroxyethyl cellulose (HEC) yakhala imodzi mwama cellulose ether omwe amagwiritsidwa ntchito kwambiri chifukwa cha kusungunuka kwake kwamadzi, kukhazikika komanso kukhuthala kwake. Poyerekeza ndi ma cellulose ethers ena, HEC ili ndi maubwino ena pakusungunuka kwamadzi ndi kukhazikika kwamankhwala, ndipo ndiyoyenera kugwiritsa ntchito zomwe zimafuna mayankho owonekera komanso kusinthasintha kwa pH. HPMC imapambana m'madera ena chifukwa cha kukhuthala kwake komanso kutentha kwa gelling, pamene HPC ndi CMC zimakhala ndi malo ofunikira m'magawo awo ogwiritsira ntchito chifukwa cha kupanga mafilimu ndi ubwino wake. Malinga ndi zofunikira pakugwiritsa ntchito, kusankha ether yoyenera ya cellulose kumatha kukulitsa magwiridwe antchito azinthu komanso zotsika mtengo.
Nthawi yotumiza: Jul-10-2024