Choyamba, English chidule cha zipangizo wothandiza
MC: Methyl cellulose
EC: ethyl cellulose
HPC: hydroxypropyl cellulose
HPMC: hydroxypropyl methylcellulose
CAP: Cellulose acetate phthalates
HPMCP: hydroxypropyl cellulose phthalates
HPMCAS: hydroxypropyl methyl cellulose acetate succinate
Cmc-na: Sodium carboxymethyl cellulose
MCC: cellulose ya Microcrystalline
PVP: Povidone
Msomali: polyethylene glycol
PVA: mowa wa polyvinyl
Cms-na: Wowuma wa sodium carboxymethyl
PVPP: Povidone yolumikizidwa
CCNa: crosslinked sodium carboxymethyl cellulose
Chachiwiri, kugwiritsa ntchito zinthu zina zothandizira
1. Lactose: piritsi: filler, makamaka ufa mwachindunji piritsi filler;Jekeseni: chitetezo cha lyophilized
2. Microcrystalline mapadi: piritsi: ufa mwachindunji mbamuikha piritsi filler;"Zomatira zouma";Mapiritsi okhala ndi 20% microcrystalline cellulose amakhala ngati disintegrators
3. Methyl cellulose: piritsi: zomatira;Woyimitsidwa wothandizira: thandizo loyimitsa;Kukonzekera kwapang'onopang'ono (koyendetsedwa): hydrophilic gel skeleton material (zofooka)
4 sodium carboxymethyl cellulose: mapiritsi: zomatira;Woyimitsidwa wothandizira: thandizo loyimitsa;Kukonzekera kwapang'onopang'ono (koyendetsedwa): hydrophilic gel skeleton material
5. Ethyl cellulose: piritsi: zomatira (zosasungunuka m'madzi);Kukonzekera kwapang'onopang'ono (koyendetsedwa): zida za mafupa kapena zinthu zoyendetsedwa ndi membrane;Kubalalika kolimba: zinthu zonyamulira zosasungunuka
6 hydroxypropyl mapadi: piritsi: zomatira, filimu zokutira zakuthupi;Woyimitsidwa wothandizira: thandizo loyimitsa;Kukonzekera kwapang'onopang'ono (koyendetsedwa): hydrophilic gel skeleton material, microporous membrane yokutidwa ndi pore-inducing agent
7. Hydroxypropyl methyl cellulose (hydroxypropyl methyl cellulose) : piritsi: zomatira, zopangira mafilimu;Woyimitsidwa wothandizira: thandizo loyimitsa;Kukonzekera kwapang'onopang'ono komanso koyendetsedwa: hydrophilic gel skeleton material, microporous membrane yokutidwa ndi pore-inducing agent
8. Ma cellulose acetate phthalates: enteric material
9. Hydroxypropyl cellulose phthalates: zinthu zamkati
10. Hydroxypropyl cellulose acetate succinate: enteric material
11. Polyvinyl phthalate (PVAP) : zinthu zamkati
12 Styrene Maleic acid copolymer (StyMA): matumbo sungunuka zakuthupi
13. Acrylic resin (mtundu wa enteric I, II, III), Eudragit L, Eudragit S (nthawi zina Eudragit L100 kapena Eudragit S 100): zinthu zamkati
14.Eudragit RL, Eudragit RS: : Zosasungunuka zonyamulira
15.Eudragit E (lofanana ndi akiliriki IV): chapamimba sungunuka polima zinthu
16 Cellulose acetate: zinthu zopanda madzi, zitha kugwiritsidwa ntchito kupaka kapena kukonza mapiritsi a pampu a osmotic.
17. Polyvinylpyrrolidone (povidone PVP) : mapiritsi: zomatira;Piritsi: chapamimba sungunuka filimu ❖ kuyanika zakuthupi;Pellets: nifedipine pellets (kubalalitsidwa kolimba);Woyimitsidwa wothandizira: thandizo loyimitsa;
Kubalalika kolimba: zonyamulira zosungunuka ndi madzi;Kukonzekera kwapang'onopang'ono (koyendetsedwa): hydrophilic colloid skeleton material;Kukonzekera kwapang'onopang'ono (koyendetsedwa): wothandizira pore-inducing pamapiritsi okhala ndi nembanemba ya microporous
18. Polyvinyl mowa: filimu wothandizira: filimu kupanga zinthu, kuyimitsidwa thandizo
19. Sodium carboxymethyl wowuma: piritsi: wosokoneza wothandizira
20. Povidone yolumikizana ndi mtanda: Piritsi: disintegrant
21. Crosslinked sodium carboxymethyl cellulose: piritsi: disintegrating agent
22. Ma cellulose a hydroxypropyl otsika: Piritsi: disintegrant
23. Polylactic acid: biodegradable polima zakuthupi, ntchito yokonza microspheres, nanoparticles, etc.
24. Glycerol (sorbitol propylene glycol imagwira ntchito kwambiri ku glycerol)
Kukonzekera kwamadzimadzi: zosungunulira, jekeseni zosungunulira, kuyimitsidwa thandizo, moisturizer
Plasticizer mu kapisozi ndi zokutira zakuthupi
Mafuta odzola, ma transdermal delivery systems: olimbikitsa kulowa
Wonjezerani kunyowa kwa mankhwala a hydrophobic, osmotic pressure regulator mu intravenous mafuta emulsion
Glycerin gelatin (mafuta, suppositories, olimba dispersions)
25. Glycerin gelatin
Mapiritsi otaya: matrix osungunuka m'madzi
Suppository: matrix osungunuka m'madzi
Mafuta: Masanjidwe osungunuka amadzi
26. Sodium dodecyl sulfate (anionic surfactant)
Emulsions, mafuta odzola: emulsifiers
Chonyowetsa pokonzekera zolimba/mafuta a mapiritsi
solubilizer
27. Polyethylene glycol (PEG)
Mapiritsi: Mafuta osungunuka m'madzi (PEG 4000, 6000)
Piritsi: Plasticizer mu filimu zokutira mankhwala
Kapisozi: Kapisozi yofewa yopanda mafuta sing'anga (PEG 400)
Mapiritsi otaya: Matrix osungunuka ndi madzi (PEG 4000, 6000,9300)
Suppository: suppository matrix
Aerosol: Zosungunulira zobisika (PEG 400, 600)
Jekeseni: Zosungunulira (PEG 400, 600)
Kukonzekera kwamadzi: Zosungunulira (PEG 400, 600)
Kubalalika kolimba: chonyamulira
Kukonzekera kwapang'onopang'ono (koyendetsedwa): wothandizira pore-inducing mu mapiritsi okhala ndi nembanemba ya microporous
Percutaneous mayamwidwe kukonzekera: transdermal mayamwidwe enhancer
28. Poloxam (” zwitterionic “surfactant) Mnzake wosamala anazindikira kusiyana apa, tsopano kukonzedwa” Poloxam “non-ionic surfactant, osati zwitterionic surfactant!
Chonyamulira chobalalika cholimba, matrix opangira ma suppository, emulsifier ya jakisoni kapena kulowetsedwa
Chidule cha antiseptic ndi bacteriostatic agents
Hydroxyl benzene ester (neper gold), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (new clean out), benzalkonium chloride (jie er die), chlorhexidine acetate, benzyl alcohol (local pain) nthawi yomweyo, zolumikizana ndi tertiary butyl mowa (ululu wa m'deralo) nthawi yomweyo, nitrobenzene, mercury, thimerosal, disinfection net, ortho-phenyl phenol, phenoxyethanol, mafuta a eucalyptus, sinamoni mafuta, peppermint mafuta, etc.
Chachinayi, njira yotseketsa
1/ Glucose jakisoni, mafuta emulsion wa jekeseni mtsempha, dextran, sodium kolorayidi kulowetsedwa, pulagi mphira ndi zina otentha kukanikiza yolera yotseketsa;
2/ jekeseni wa Vitamini C, jekeseni wa procaine hydrochloride, jakisoni wa cortisone acetate, madontho a m'maso a chloramphenicol adatsekedwa ndi mpweya wozungulira;
3/ Mafuta a jakisoni, matrix opaka mafuta, ampoule pogwiritsa ntchito njira yowuma yowumitsa kutentha;
4/Asepsis chipinda mpweya, ntchito tebulo pamwamba: ultraviolet choletsa njira kapena mpweya fumigation njira;
5/ Dzanja, zida za aseptic: njira yoletsa mankhwala
6/ jakisoni wa insulin ndi zinthu zina zachilengedwe: njira yosefera
V. Zofananira
1. Noyes-whitney equation: ikufotokoza kuchuluka kwa kusungunuka kwa mankhwala olimba.
2. Wovuta wachibale chinyezi cha osakaniza
hygroscopicity ya ufa wa P68)
3. Mtengo wosinthirasuppository P87)
4.Poiseuile formula: fotokozani zomwe zimathandizira kusefera (jekeseni P124)
5. Njira yowerengera ya isotonic regulation ndi njira yochepetsera kuzizirajakisoni P156)
6. Kuwerengera mtengo wa HLB wa osakaniza surfactantmadzi P178)
Tekinoloje yoyenera yokonzekera
1. Microcapsule: njira ya condensation (imodzi, zovuta), njira yosungunulira yosasungunuka, njira yosinthira kutentha, njira yowumitsa madzi, njira yowumitsira utsi, njira yopopera, kuyimitsa mpweya, njira yolumikizira mawonekedwe, njira yolumikizira ma radiation.
2. Kuphatikizira: njira yothira madzi amadzimadzi, njira yopera, njira yowumitsa yowumitsa, njira yowumitsa utsi.
3. Ma dispersions olimba: njira yosungunulira, njira yosungunulira, zosungunulira - njira yosungunulira, zosungunulira - njira yoyanika, njira yopera.
4. Liposomes: njira jakisoni, woonda filimu kubalalitsidwa njira, akupanga kubalalitsidwa njira, reverse gawo evaporation njira, amaundana kuyanika njira.
5. Microspheres: emulsification - kuchiritsa njira, kupopera mbewu mankhwalawa, njira kuyanika madzi
6. Nanoparticles: micellar polymerization, emulsion polymerization, interfacial polymerization, madzi kuyanika njira
7. Pellet: njira yowiritsa granulation, kupopera granulation, njira yophikira mphika, extrusion sphericity njira, centrifugal projectile njira, kuyanika madzi.
8 suppository: njira yotentha yosungunula, njira yopondera yozizira, njira yokanda
9. Mafuta: njira yopera, njira yosungunula, emulsification njira
10 filimu wothandizira: homogenized slurry flow filimu kupanga njira, kuthamanga-kusungunuka filimu kupanga njira, composite film kupanga njira
Zisanu ndi ziwiri, zowonjezera zowonjezera
1. Microcapsule: gelatin - Arabic chingamu
2. Kuphatikizana: cyclodextrin
3. Kubalalitsidwa kolimba: PEG, PVP
4. Liposomes: phospholipid-cholesterol
5. Microspheres: gelatin, albumin, PLA, etc
6. Suppository: koko batala
7. Mafuta: Mafuta odzola, etc
8 wothandizila filimu: PVA
Eyiti, kanthawi pang'ono
1. Ampoule yosawilitsidwa idzasiyidwa kwa maola osapitilira 24;
2. Kusungirako madzi a jakisoni asapitirire maola 12;
3. Kutsekereza jakisoni wamba kumalizidwa mkati mwa maola 12 mutatha kupotoza;
4. Kulowetsedwa ndi kukonzekera kwa yankho kudzamalizidwa mkati mwa maola 4 kuchokera ku cholera
9. Zinthu zowunikira zabwino zokhudzana ndi kukonzekera mankhwala
1. Mapiritsi: mawonekedwe;Kagawo kulemera kusiyana;Kuuma ndi brittleness;Disintegrating digiri;Kuwonongeka kapena kumasulidwa;Kufanana kwa zomwe zili
2. Wobalalitsa: kufanana;Chinyezi.Kutsegula kusiyana kwa kuchuluka;Kuyezetsa thanzi;Kuwunika kwa granularity
3. Granule: maonekedwe;Kukula kwa tinthu;Youma kuwonda;Sungunulani;Kusiyana kwa katundu
4. Kapisozi: maonekedwe;Chinyezi.Kutsegula kusiyana kwa kuchuluka;Kugawanika ndi kutha.
5. Kutaya mapiritsi: kusiyana kwa kulemera;Kuwonongeka kwa nthawi yoyendera malire, etc.
6. Suppository: maonekedwe;Kusiyana kulemera;Nthawi yosungunuka;Malo osungunuka;Kuyesa kwa in vitro dissolution komanso kuyesa kwa mayamwidwe mu vivo
7. Pulasita: kukula kwa tinthu;Katundu;Malire a tizilombo;Main mankhwala zili;Thupi katundu;Kulimbikitsa;Kukhazikika;Kutulutsidwa, kulowa ndi kuyamwa kwa mankhwala odzola.
8. Zigamba za Transdermal: kusiyana kwa kulemera;Kusiyana kwa dera;Kufanana kwa zomwe zili;Digiri yotulutsa, etc.
10. Matanthauzo osiyanasiyana
1. Micro capsule: ndi kapisozi kakang'ono kamene kamapangidwa ndi kukulunga mankhwala olimba kapena amadzimadzi (otchedwa capsule core) muzinthu zachilengedwe kapena zopangidwa ndi polima (zotchedwa capsule material).1-5000 microns
2. Pellet: imatanthawuza chinthu chozungulira chokhala ndi m'mimba mwake osakwana 2.5mm wopangidwa ndi mankhwala ndi zowonjezera.
3. Microsphere: chigoba chamtundu wa microscopic spherical opangidwa ndi Kutha kapena dispersive mankhwala mu chimango cha polima zipangizo, ndi tinthu kukula kawirikawiri pakati 1 ndi 250μm.
4. Nanoparticles: olimba colloidal particles wopangidwa ndi zinthu polymeric, ndi tinthu kukula mu osiyanasiyana 10 ~ 1000nm.
5. Mapiritsi ogwetsa: amatanthauza mankhwala olimba kapena amadzimadzi ndi zinthu zoyenera (zomwe zimadziwika kuti matrix) kusakaniza kotentha kusungunuka, kugwera mu condensate yosakanikirana, condensation ya condensation ndi yopangidwa ndi pellet yaing'ono.
Nthawi yotumiza: Sep-09-2022