Ndi kuzama kwa kafukufuku wa machitidwe operekera mankhwala ndi zofunikira zokhwima, zowonjezera zowonjezera mankhwala zikutuluka, zomwe hydroxypropyl methylcellulose amagwiritsidwa ntchito kwambiri. Pepalali likuwunikiranso ntchito zapakhomo ndi zakunja za hydroxypropyl methylcellulose. Kupanga njira ndi ubwino ndi kuipa, zipangizo zamakono ndi ziyembekezo zoweta bwino, ndi ntchito yake m'munda wa excipients mankhwala.
Mawu ofunika: othandizira mankhwala; hydroxypropyl methylcellulose; kupanga; ntchito
1 Mawu Oyamba
Zothandizira zamankhwala zimatanthawuza nthawi zonse za mankhwala ena onse omwe amawonjezeredwa pokonzekera kupatulapo mankhwala akuluakulu kuti athetse kukhazikika, kupezeka ndi chitetezo cha kukonzekera popanga ndi kupanga kukonzekera. Zothandizira mankhwala ndizofunika kwambiri pakukonzekera mankhwala. Pali mitundu yambiri ya mankhwala opangira mankhwala m'nyumba ndi kunja, koma m'zaka zaposachedwapa, zofunikira za chiyero, kusungunuka, kukhazikika, bioavailability mu vivo, kusintha kwa mankhwala ndi kuchepetsa zotsatira za mankhwala zikukwera kwambiri. , kupanga kutuluka kwachangu kwa zowonjezera zatsopano ndi njira zofufuzira pofuna kupititsa patsogolo luso la kukonzekera mankhwala ndi khalidwe la ntchito. Zitsanzo zambiri zikuwonetsa kuti hydroxypropyl methylcellulose imatha kukwaniritsa zomwe zili pamwambapa monga chithandizo chamankhwala chapamwamba. Mkhalidwe wamakono wa kafukufuku wakunja ndi kupanga ndi ntchito yake m'munda wa kukonzekera mankhwala akufotokozedwa mwachidule.
2 Chidule cha katundu wa HPMC
HPMC ndi yoyera kapena yachikasu pang'ono, yopanda fungo, yopanda fungo, yopanda poizoni yomwe imapezeka ndi etherification ya cellulose ya alkali, propylene oxide ndi alkyl chloride. Amasungunuka mosavuta m'madzi ochepera 60 ° C ndi 70% ethanol ndi acetone, isoacetone, ndi dichloromethane mix solvent; HPMC ili ndi kukhazikika kwamphamvu, makamaka kuwonetseredwa: choyamba, yankho lake lamadzimadzi liribe ndalama ndipo silichitapo kanthu ndi mchere wachitsulo kapena mankhwala a ionic organic; chachiwiri, imalimbananso ndi ma acid kapena maziko. Wokhazikika. Ndi mikhalidwe yokhazikika ya HPMC yomwe imapangitsa kuti mtundu wa mankhwala omwe ali ndi HPMC akhale okhazikika kuposa omwe ali ndi zopangira zachikhalidwe. Mu toxicology kuphunzira HPMC monga excipients, zikusonyeza kuti HPMC sadzakhala zimapukusidwa mu thupi, ndipo sachita nawo kagayidwe thupi la munthu. Mphamvu, palibe poizoni ndi zotsatira zoyipa za mankhwala, otetezeka mankhwala excipients.
3 Kafukufuku wokhudza kupanga zapakhomo ndi zakunja kwa HPMC
3.1 Mwachidule za luso kupanga HPMC kunyumba ndi kunja
Pofuna kuthana bwino ndi zomwe zikuchulukirachulukira komanso zomwe zikuchulukirachulukira zakukonzekera kwamankhwala kunyumba ndi kunja, ukadaulo wopanga ndi njira ya HPMC ikukulanso mosalekeza panjira yovutitsa komanso yayitali. The ndondomeko kupanga HPMC akhoza kugawidwa mu mtanda njira ndi mosalekeza njira. Magulu akuluakulu. Njira yopitilira nthawi zambiri imagwiritsidwa ntchito kunja, pomwe njira ya batch imagwiritsidwa ntchito kwambiri ku China. Kukonzekera kwa HPMC kumaphatikizapo masitepe a alkali cellulose kukonzekera, etherification reaction, kuyenga chithandizo, ndi mankhwala omalizidwa. Pakati pawo, pali mitundu iwiri ya njira njira kwa etherification anachita. : Njira ya gasi ndi njira yamadzimadzi. Kunena zoona, njira ya gasi ili ndi ubwino wa kupanga kwakukulu, kutentha kochepa, kutentha kwafupipafupi, nthawi yochepa yochitira, ndi kuwongolera koyenera, koma kuthamanga kwazomwe kumakhala kwakukulu, ndalamazo zimakhala zazikulu, ndipo pakangochitika vuto, n'zosavuta kuchita. kuyambitsa ngozi zazikulu. Njira yamadzimadzi nthawi zambiri imakhala ndi ubwino wa kukakamiza otsika, chiopsezo chochepa, mtengo wotsika wa ndalama, kuwongolera khalidwe kosavuta, ndi kusintha kosavuta kwa mitundu; koma pa nthawi yomweyo, riyakitala chofunika ndi madzi gawo njira sangakhale lalikulu kwambiri, amenenso malire anachita mphamvu. Poyerekeza ndi njira ya gasi, nthawi yochitapo ndi yayitali, mphamvu yopangira ndi yaying'ono, zida zofunika ndi zambiri, ntchitoyo ndi yovuta, ndipo kuwongolera ndi kulondola kumakhala kotsika kuposa njira ya gasi. Pakali pano, mayiko otukuka monga Europe ndi United States makamaka amagwiritsa ntchito gasi gawo njira. Pali zofunika kwambiri pankhani yaukadaulo ndi ndalama. Kutengera momwe zinthu ziliri m'dziko lathu, njira yamadzimadzi ndiyofala kwambiri. Komabe, pali madera ambiri ku China omwe akupitiliza kusintha ndi kupanga matekinoloje, amaphunzira kuchokera kumayiko otsogola, ndikuyamba njira zopitilira pang'ono. Kapena njira yobweretsera njira yakunja ya gasi.
3.2 Kupititsa patsogolo ukadaulo wapakhomo wa HPMC
HPMC m'dziko langa ili ndi kuthekera kwakukulu kwachitukuko. Pansi pa mwayi wabwino wotere, ndi cholinga cha wofufuza aliyense kuti apititse patsogolo ukadaulo wopanga wa HPMC ndikuchepetsa kusiyana pakati pa makampani apakhomo a HPMC ndi mayiko otsogola akunja. Njira ya HPMC Ulalo uliwonse mu kaphatikizidwe kake ndi wofunikira kwambiri ku chinthu chomaliza, chomwe ma alkalization ndi etherification reaction [6] ndizofunikira kwambiri. Choncho, alipo zoweta HPMC kupanga luso akhoza kuchitidwa kuchokera mbali ziwirizi. Kusintha. Choyamba, kukonzekera kwa cellulose ya alkali kuyenera kuchitika pa kutentha kochepa. Ngati mankhwala otsika kachulukidwe akakonzedwa, ena okosijeni akhoza kuwonjezeredwa; ngati mankhwala othamanga kwambiri akonzedwa, njira yotetezera gasi ya inert ingagwiritsidwe ntchito. Kachiwiri, zochita etherification ikuchitika pa kutentha kwambiri. Ikani toluene mu zida za etherification pasadakhale, tumizani cellulose ya alkali mu zida ndi mpope, ndikuwonjezera kuchuluka kwa isopropanol malinga ndi zosowa. Chepetsani chiŵerengero cholimba-chamadzimadzi. Ndipo gwiritsani ntchito makina owongolera makompyuta, omwe amatha kuyankha kutentha mwachangu, magawo a Njira monga kuthamanga ndi pH amasinthidwa zokha. Zachidziwikire, kuwongolera kwaukadaulo wopanga HPMC kumathanso kusinthidwa kuchokera panjira, kugwiritsa ntchito zinthu zopangira, kuyenga chithandizo ndi zina.
4 Kugwiritsa ntchito HPMC pazamankhwala
4.1 Kugwiritsa ntchito HPMC pokonza mapiritsi otulutsidwa mosalekeza
M'zaka zaposachedwa, ndikukula kosalekeza kwa kafukufuku woperekera mankhwala osokoneza bongo, kupangidwa kwa HPMC yokhala ndi mamasukidwe apamwamba pakugwiritsa ntchito kukonzekera kosalekeza kwakopa chidwi chambiri, ndipo kumasulidwa kokhazikika ndikwabwino. Poyerekeza, pali kusiyana kwakukulu pakugwiritsa ntchito mapiritsi a matrix omasulidwa mosalekeza. Mwachitsanzo, poyerekeza mapiritsi a m'nyumba ndi akunja a HPMC a mapiritsi otulutsidwa ndi nifedipine komanso ngati matrix a mapiritsi a propranolol hydrochloride omasulidwa, apeza kuti kugwiritsa ntchito HPMC m'nyumba pokonzekera kumasulidwa kumafuna kusintha kwina kuti mupitirize kupititsa patsogolo mlingo wa zoweta kukonzekera.
4.2 Kugwiritsa ntchito HPMC pakukula kwamafuta amankhwala
Chifukwa chofuna kuyang'anitsitsa kapena kuchiza zida zina zachipatala masiku ano, polowa kapena kutuluka ziwalo zaumunthu ndi minofu, pamwamba pa chipangizocho chiyenera kukhala ndi mafuta enaake, ndipo HPMC ili ndi zinthu zina zokometsera. Poyerekeza ndi mafuta ena opangira mafuta, HPMC ikhoza kugwiritsidwa ntchito ngati mankhwala opangira mafuta , zomwe sizingachepetse kuvala kwa zipangizo, komanso kukwaniritsa zofunikira za mafuta achipatala ndi kuchepetsa ndalama.
4.3 Kugwiritsa ntchito HPMC ngati filimu yachilengedwe yosungunula madzi yosungunuka m'madzi ndi zokutira filimu ndi zinthu zopangira filimu.
Poyerekeza ndi zida zina zamapiritsi zokutira zachikhalidwe, HPMC ili ndi maubwino odziwikiratu potengera kuuma, kukhazikika komanso kuyamwa kwa chinyezi. HPMC ya makalasi kukhuthala osiyana angagwiritsidwe ntchito ngati ma CD sungunuka madzi kwa mapiritsi ndi mapiritsi. Itha kugwiritsidwanso ntchito ngati filimu yoyika ma organic zosungunulira. Titha kunena kuti HPMC ndiyomwe imagwiritsidwa ntchito kwambiri popaka filimu m'dziko langa. Kuonjezera apo, HPMC ingagwiritsidwenso ntchito ngati filimu yopangira mafilimu mu filimuyi, ndipo filimu yowonongeka yamadzi yosungunuka m'madzi yochokera ku HPMC imagwiritsidwa ntchito kwambiri posungira chakudya, makamaka zipatso.
4.4 Kugwiritsa ntchito HPMC ngati chipolopolo cha kapisozi
HPMC itha kugwiritsidwanso ntchito ngati zinthu pokonzekera zipolopolo za kapisozi. Ubwino wa makapisozi a HPMC ndikuti amathetsa kuphatikizika kwa makapisozi a gelatin, amalumikizana bwino ndi mankhwala, amakhala okhazikika kwambiri, amatha kusintha ndikuwongolera kutulutsa kwamankhwala, kusintha khalidwe la mankhwala, Lili ndi ubwino wa kumasulidwa kwa mankhwala. ndondomeko. Mwachidziwitso, makapisozi a HPMC amatha m'malo mwa makapisozi omwe alipo kale, kuyimira tsogolo la makapisozi olimba.
4.5 Kugwiritsa ntchito HPMC ngati woyimitsa
HPMC imagwiritsidwa ntchito ngati choyimitsa, ndipo kuyimitsa kwake ndikwabwino. Ndipo zoyesera zikuwonetsa kuti kugwiritsa ntchito zinthu zina wamba polima monga suspending wothandizira kukonzekera youma kuyimitsidwa akuyerekezedwa ndi HPMC monga suspending wothandizira kukonzekera youma kuyimitsidwa. Kuyimitsidwa kowuma ndikosavuta kukonzekera ndipo kumakhala ndi kukhazikika kwabwino, ndipo kuyimitsidwa kopangidwa kumakwaniritsa zofunikira zazizindikiro zosiyanasiyana za kuyimitsidwa kowuma. Choncho, HPMC nthawi zambiri ntchito ngati suspending wothandizira kwa ophthalmic kukonzekera.
4.6 Kugwiritsa ntchito HPMC ngati chotchinga, chotulutsa pang'onopang'ono ndi porogen
HPMC itha kugwiritsidwa ntchito ngati chotchinga, chotulutsa nthawi zonse ndi pore-forming agent kuti achedwe ndikuwongolera kutulutsidwa kwa mankhwala. Masiku ano, HPMC imagwiritsidwanso ntchito kwambiri pokonzekera kumasulidwa kosalekeza ndikukonzekera mankhwala azikhalidwe zaku China, monga mapiritsi a Tianshan Snow Lotus omasulidwa. Kugwiritsa ntchito, kutulutsa kwake kosalekeza ndikwabwino, ndipo njira yokonzekera ndiyosavuta komanso yokhazikika.
4.7 Kugwiritsa ntchito HPMC ngati guluu wokhuthala ndi colloid
HPMC itha kugwiritsidwa ntchito ngati thickener [9] kupanga colloid zoteteza, ndipo kafukufuku woyeserera wasonyeza kuti kugwiritsa ntchito HPMC ngati thickener kumathandizira kukhazikika kwa carbon activated carbon. Mwachitsanzo, amagwiritsidwa ntchito pokonza pH-tcheru levofloxacin hydrochloride ophthalmic wokonzeka kugwiritsa ntchito gel osakaniza. HPMC imagwiritsidwa ntchito ngati thickener.
4.8 Kugwiritsa ntchito HPMC ngati bioadhesive
Zomatira zomwe zimagwiritsidwa ntchito muukadaulo wa bioadhesion ndi ma macromolecular mankhwala okhala ndi bioadhesive properties. Ndi kutsatira m`mimba mucosa, m`kamwa mucosa ndi mbali zina, kupitiriza ndi zolimba kukhudzana pakati pa mankhwala ndi mucosa amalimbikitsidwa kukwaniritsa bwino achire zotsatira. . Zitsanzo zambiri zogwiritsira ntchito zikuwonetsa kuti HPMC ikhoza kukwaniritsa zofunikira zomwe zili pamwambazi monga bioadhesive.
Kuphatikiza apo, HPMC itha kugwiritsidwanso ntchito ngati choletsa mpweya wa gels topical and self-microemulsifying systems, komanso mumakampani a PVC, HPMC itha kugwiritsidwa ntchito ngati choteteza kubalalitsidwa mu polymerization ya VCM.
5 Mapeto
Mwachidule, HPMC yakhala ikugwiritsidwa ntchito kwambiri pokonzekera mankhwala ndi zina chifukwa cha mawonekedwe ake apadera a physicochemical and biological properties. Ngakhale zili choncho, HPMC ikadali ndi mavuto ambiri pokonzekera mankhwala. Kodi ntchito yeniyeni ya HPMC ndi yotani pakugwiritsa ntchito; momwe mungadziwire ngati ili ndi zotsatira za pharmacological; ndi makhalidwe otani omwe ali nawo mu njira yake yotulutsa, ndi zina zotero. Zingawoneke kuti ngakhale kuti HPMC imagwiritsidwa ntchito kwambiri, mavuto ambiri ayenera kuthetsedwa mwamsanga. Ndipo ofufuza ochulukirachulukira akugwira ntchito yochulukirapo kuti agwiritse ntchito bwino HPMC muzamankhwala, motero amalimbikitsa mosalekeza chitukuko cha HPMC pazamankhwala othandizira mankhwala.
Nthawi yotumiza: Nov-02-2022