Hydroxypropyl Methylcellulose (HPMC) ndi semi-synthetic, inert, high-viscosity polima yomwe imagwiritsidwa ntchito kwambiri popanga mankhwala. Maonekedwe ake apadera a thupi ndi mankhwala amapangitsa kuti ikhale yofunika kwambiri pamakampani opanga mankhwala, kupanga mafilimu, kukhuthala, kukhazikika komanso kuyanjana kwachilengedwe.
Zinthu zoyambira za HPMC
HPMC imapangidwa ndi methylating ndi hydroxypropylating cellulose. Imakhala ndi kusungunuka kwamadzi bwino komanso thermoplasticity, ndipo imasungunuka mwachangu m'madzi ozizira kupanga njira yowonekera ya colloidal. Solubility ake ndi mamasukidwe akayendedwe akhoza lizilamuliridwa ndi kusintha mlingo wa m'malo ndi digiri ya polymerization, amene amalola HPMC kukwaniritsa zofunika zosiyanasiyana mankhwala formulations.
Malo ofunsira
1. Mankhwala osokoneza bongo
HPMC imagwiritsidwa ntchito kwambiri popanga mankhwala oletsa kumasulidwa. Chifukwa cha kusungunuka kwake m'madzi komanso kupanga ma gels, HPMC imatha kuwongolera kuchuluka kwa mankhwala. Kutupa kwake m'matumbo am'mimba kumapangitsa kuti mankhwalawa atulutsidwe pang'onopang'ono pakapita nthawi, kuwongolera ndende ya plasma ya mankhwalawa, kuchepetsa kuchuluka kwa mankhwala, ndikuwongolera kutsatira kwa odwala.
2. Zomangira ndi zophatikizira mapiritsi
Monga chomangira komanso chophatikizira pamapiritsi, HPMC imatha kukulitsa mphamvu zamakina amapiritsi ndikuwonetsetsa kuti mapiritsi akusweka ndikutulutsa zosakaniza zomwe zimagwira ntchito munthawi yoyenera. Zomatira zake zimathandiza kumangiriza tinthu tating'onoting'ono tomwe timapanga tinthu tating'onoting'ono tomwe timapanga piritsi lamphamvu, pomwe kutupa kwake kumapangitsa kuti mapiritsiwo awonongeke mwachangu m'madzi.
3. Mafilimu opangira mafilimu
HPMC ndi chinthu chofunikira pokonzekera zokutira mafilimu a mankhwala. Angagwiritsidwe ntchito ngati zoteteza filimu ❖ kuyanika kuteteza mankhwala ku chinyezi, mpweya ndi kuwala, potero kusintha bata la mankhwala. Komanso, HPMC Angagwiritsidwenso ntchito ngati ❖ kuyanika enteric kuteteza mankhwala kumasulidwa m`mimba ndi kuonetsetsa kuti mankhwala odzipereka m`matumbo.
4. Kukonzekera kwa Ophthalmic
Pokonzekera ophthalmic, HPMC nthawi zambiri imagwiritsidwa ntchito pokonzekera misozi yokumba ndi madontho a maso. Kuwoneka kwake kwakukulu komanso kuyanjana kwachilengedwe kumathandizira kupanga filimu yoteteza pamwamba pa diso, kuthira mafuta m'maso, ndikuchepetsa zizindikiro zamaso owuma.
5. Makapisozi
HPMC angagwiritsidwe ntchito kukonzekera makapisozi olimba ndi makapisozi zofewa. Poyerekeza ndi makapisozi amtundu wa gelatin, makapisozi a HPMC ali ndi kukhazikika kwamankhwala kwabwinoko, sikosavuta kuyamwa chinyezi, ndipo amakhala ochezeka kwa odya zamasamba ndi okhulupirira achipembedzo.
Zinthu zokopa
1. Viscosity
The mamasukidwe akayendedwe a HPMC ndi chimodzi mwa zizindikiro zofunika za ntchito yake. High-viscosity HPMC ingagwiritsidwe ntchito popanga mankhwala opangidwa ndi mafilimu opangidwa ndi mafilimu, pamene HPMC yotsika kwambiri ya viscosity ndi yoyenera kugwiritsidwa ntchito ngati binder ndi disintegrant.
2. Digiri ya m'malo
Mlingo wa kulowetsedwa (DS) ndi kusintha kwa molar (MS) wa HPMC zimakhudza mwachindunji kusungunuka kwake komanso kupanga gel osakaniza. Kusintha koyenera kwa digiri ya m'malo kumatha kukulitsa zotsatira za HPMC mumitundu yosiyanasiyana yamankhwala.
3. Zinthu zachilengedwe
Kuchita kwa HPMC kumakhudzidwanso ndi zinthu zachilengedwe monga kutentha, mtengo wa pH ndi mphamvu ya ionic. Zinthu izi ziyenera kuganiziridwa pokonzekera kupanga mankhwala kuti zitsimikizire kuti HPMC imagwira ntchito bwino.
Hydroxypropyl methylcellulose (HPMC), monga multifunctional, high-performance pharmaceutical excipient, amagwiritsidwa ntchito kwambiri m'madera ambiri monga kutulutsidwa kwa mankhwala osokoneza bongo, mapiritsi, kukonzekera mafilimu, kukonzekera maso ndi makapisozi. Ndi kusintha mamasukidwe ake mamasukidwe akayendedwe ndi mlingo wa m'malo, akhoza kukwaniritsa zosowa zosiyanasiyana mankhwala formulations ndi kwambiri kusintha bata ndi bioavailability mankhwala. Ndi kupita patsogolo kosalekeza kwaukadaulo wamankhwala, chiyembekezo chogwiritsa ntchito HPMC chidzakhala chokulirapo.
Nthawi yotumiza: Jul-11-2024