Hydroxypropyl cellulose, chothandizira mankhwala, chimagawidwa mu low-substituted hydroxypropyl cellulose (L-HPC) ndi high-substituted hydroxypropyl cellulose (H-HPC) malinga ndi zomwe zili m'malo mwake hydroxypropoxy. L-HPC imakula mu njira ya colloidal m'madzi, imakhala ndi zomatira, mapangidwe a filimu, emulsification, ndi zina zotero, ndipo amagwiritsidwa ntchito makamaka ngati chophatikizira ndi binder; pamene H-HPC ndi sungunuka m'madzi ndi zosungunulira zosiyanasiyana organic pa firiji, ndipo ali wabwino thermoplasticity. , kugwirizanitsa ndi kupanga mafilimu, filimu yopangidwa ndi yolimba, yonyezimira, komanso yosasunthika, ndipo imagwiritsidwa ntchito makamaka ngati filimu yopangira mafilimu ndi zokutira. Kugwiritsiridwa ntchito kwapadera kwa hydroxypropyl cellulose mu kukonzekera kolimba kwayamba tsopano.
1. Monga disintegrant yokonzekera zolimba monga mapiritsi
Pamwamba pa otsika m'malohydroxypropyl cellulosema crystalline particles ndi osagwirizana, okhala ndi mawonekedwe owoneka ngati thanthwe. Kapangidwe kameneka kameneka sikumangopangitsa kuti ikhale ndi malo okulirapo, komanso ikakanizidwa piritsi limodzi ndi mankhwala ndi zina zowonjezera, ma pores ambiri ndi ma capillaries amapangidwa pakatikati pa piritsi, kuti pachimake piritsilo liwonjezeke chinyezi. kuchuluka kwa mayamwidwe ndi kuyamwa kwamadzi kumawonjezera kutupa. Kugwiritsira ntchito L-HPC monga chothandizira kungapangitse kuti piritsilo liwonongeke mofulumira kukhala ufa wofanana, ndipo limapangitsa kwambiri kusungunuka, kusungunuka ndi bioavailability ya piritsi. Mwachitsanzo, ntchito L-HPC imathandizira azingokhala paracetamol mapiritsi, aspirin mapiritsi, ndi chlorpheniramine mapiritsi, ndi kusintha mlingo kuvunda. Kuwonongeka ndi kusungunuka kwa mankhwala osasungunuka bwino monga mapiritsi a ofloxacin omwe ali ndi L-HPC ngati osungunula anali bwino kuposa omwe ali ndi PVPP yolumikizana, CMC-Na ndi CMS-Na ngati zosokoneza. Kugwiritsa ntchito L-HPC monga disintegrant yamkati ya granules mu makapisozi ndi kopindulitsa kwa kupasuka kwa granules, kumawonjezera kukhudzana kwapakati pa mankhwala ndi sing'anga yowonongeka, kumalimbikitsa kusungunuka kwa mankhwala, ndi kupititsa patsogolo bioavailability. Zokonzekera zolimba zotulutsidwa mwamsanga zomwe zimayimiridwa ndi kukonzekera kolimba kofulumira komanso kusungunuka mwamsanga kumakhala ndi zotsatira zowonongeka, zowonongeka, zowonongeka, zowonongeka kwambiri, kuchepetsa kupsa mtima kwa mankhwala kummero ndi m'mimba, ndipo ndizosavuta kutenga. ndi kukonzekera bwino. ndi zina zabwino, kukhala ndi udindo wofunikira m'munda wa pharmacy. L-HPC yakhala imodzi mwazofunikira kwambiri pakukonzekera kokhazikika kokhazikika chifukwa champhamvu ya hydrophilicity, hygroscopicity, expansibility, nthawi yaifupi ya hysteresis yoyamwa madzi, kuthamanga kwamadzi othamanga, komanso kuthamanga kwamadzi mwachangu. Ndi yabwino disintegrant kwa mapiritsi pakamwa kupasuka. Mapiritsi a Paracetamol osungunuka pakamwa adakonzedwa ndi L-HPC ngati disintegrant, ndipo mapiritsiwo adasokonekera mwachangu mkati mwa 20s. L-HPC imagwiritsidwa ntchito ngati disintegrant pamapiritsi, ndipo mlingo wake wamba ndi 2% mpaka 10%, makamaka 5%.
2. Monga chomangira pokonzekera monga mapiritsi ndi ma granules
Kapangidwe kakakulu ka L-HPC kumapangitsanso kukhala ndi mawonekedwe owoneka bwino ndi mankhwala ndi tinthu ting'onoting'ono, zomwe zimawonjezera kuchuluka kwa mgwirizano, ndipo zimakhala ndi ntchito yabwino yopangira makina. Pambuyo popanikizidwa m'mapiritsi, zimasonyeza kuuma kwambiri ndi gloss, motero kusintha khalidwe la mawonekedwe a piritsi. Makamaka mapiritsi omwe si osavuta kupanga, omasuka kapena osavuta kuwulula, kuwonjezera L-HPC kumatha kusintha mawonekedwe. Piritsi la ciprofloxacin hydrochloride lili ndi kusakhazikika bwino, kugawanika kosavuta komanso kumata, ndipo ndilosavuta kupanga mukawonjezera L-HPC, yokhala ndi kuuma koyenera, mawonekedwe okongola, komanso kuchuluka kwa kusungunuka kumakwaniritsa zofunikira. Pambuyo powonjezera L-HPC mu piritsi lotayika, mawonekedwe ake, friability, kufanana kwa kubalalikana ndi zina zimasintha kwambiri ndikuwongolera. Pambuyo pa wowuma mu mankhwala oyambirira adasinthidwa ndi L-HPC, kuuma kwa piritsi la azithromycin dispersible kunawonjezeka, friability idasinthidwa, ndipo mavuto a ngodya zoperewera ndi m'mbali zowola za piritsi yoyamba zinathetsedwa. L-HPC imagwiritsidwa ntchito ngati chomangira mapiritsi, ndipo mlingo wamba ndi 5% mpaka 20%; pamene H-HPC imagwiritsidwa ntchito ngati chomangira mapiritsi, ma granules, ndi zina zotero, ndipo mlingo wamba ndi 1% mpaka 5% ya kukonzekera.
3. Kugwiritsa ntchito kupaka filimu ndi kukonzekera kokhazikika komanso koyendetsedwa bwino
Pakalipano, zinthu zosungunuka m'madzi zomwe zimagwiritsidwa ntchito popaka filimu zimaphatikizapo hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) ndi zina zotero. Ma cellulose a Hydroxypropyl nthawi zambiri amagwiritsidwa ntchito ngati chopangira filimu muzopaka filimu zopangira premixing chifukwa cha filimu yake yolimba, zotanuka komanso zonyezimira. Ngati hydroxypropyl cellulose itasakanizidwa ndi zoyatira zina zosagwira kutentha, magwiridwe antchito ake amatha kuwongolera.
Kugwiritsa ntchito zowonjezera ndi njira zoyenera zopangira mankhwalawa kukhala mapiritsi a matrix, mapiritsi oyandama am'mimba, mapiritsi amitundu ingapo, mapiritsi okutidwa, mapiritsi opopera a osmotic ndi mapiritsi ena otulutsidwa pang'onopang'ono komanso oyendetsedwa bwino, tanthauzo lili: mankhwala m'magazi. Kuyikirapo, kuchepetsa zotsatira zoyipa, kuchepetsa kuchuluka kwa mankhwala, ndi kuyesetsa kukulitsa machiritso ndi mlingo wochepa kwambiri, ndi kuchepetsa zotsatira zoyipa. Ma cellulose a Hydroxypropyl ndi chimodzi mwazofunikira kwambiri pazokonzekera zotere. Kusungunuka ndi kutulutsidwa kwa mapiritsi a diclofenac sodium amayendetsedwa pogwiritsa ntchito hydroxypropyl cellulose ndi ethyl cellulose monga cholumikizira ndi mafupa. Pambuyo pakamwa komanso kukhudzana ndi madzi a m'mimba, pamwamba pa mapiritsi a diclofenac sodium omasulidwa nthawi zonse amathiridwa mu gel. Kupyolera mu kusungunuka kwa gel osakaniza ndi kufalikira kwa mamolekyu a mankhwala mumpata wa gel osakaniza, cholinga cha kumasulidwa kwapang'onopang'ono kwa mamolekyu a mankhwala kumatheka. Ma cellulose a Hydroxypropyl amagwiritsidwa ntchito ngati The controlled-release matrix ya piritsi, pomwe zomwe zili mu blocker ethyl cellulose zimakhala zokhazikika, zomwe zili mu piritsi zimatsimikizira kuchuluka kwa mankhwalawo, komanso mankhwala omwe ali papiritsi okhala ndi zinthu zambiri. wa hydroxypropyl cellulose Kutulutsidwa kumachedwa. Ma pellets ophimbidwa anakonzedwa pogwiritsa ntchito L-HPC ndi gawo lina la HPMC monga njira yothetsera kupaka ngati nsanjika yotupa, komanso ngati wosanjikiza-kumasulidwa kwa kupaka ndi ethyl cellulose amadzimadzi dispersion. Pamene kutupa wosanjikiza mankhwala ndi mlingo zokhazikika, polamulira makulidwe a wosanjikiza kumasulidwa wosanjikiza, yokutidwa pellets akhoza kumasulidwa pa nthawi zosiyanasiyana kuyembekezera. Mitundu ingapo ya ma pellets okutidwa okhala ndi kulemera kosiyanasiyana kwa wosanjikiza wotulutsidwa amasakanikirana kuti apange makapisozi a Shuxiong omasulidwa mosalekeza. Mu sing'anga yosungunuka, ma pellets ophimbidwa osiyanasiyana amatha kutulutsa mankhwala motsatizana nthawi zosiyanasiyana, kotero kuti zigawo zomwe zimakhala ndi thupi ndi mankhwala osiyanasiyana zimatulutsidwa munthawi yomweyo ngati kumasulidwa kosalekeza.
Nthawi yotumiza: Dec-28-2022