What is HPMC E3?

HPMC E3, or hydroxypropyl methylcellulose E3, is a type of cellulose ether that is commonly used in the pharmaceutical industry as a binder, thickener, and sustained release agent in tablet and capsule formulations. It is a non-ionic polymer that is derived from natural cellulose through chemical modification,HPMC E3 viscosity range is 2.4-3.6 mPas.

In the pharmaceutical industry, HPMC E3 is often used as an alternative to other binders, such as starch or gelatin, because it is a plant-based, vegetarian alternative. It is also highly compatible with a variety of active pharmaceutical ingredients (APIs) and excipients, making it a versatile and widely used ingredient in many pharmaceutical formulations.

One of the key benefits of HPMC E3 in pharmaceutical applications is its ability to act as a binder. When used as a binder, HPMC E3 helps to hold the active ingredient and other excipients together, forming a tablet or capsule. This is important because it ensures that the tablet or capsule maintains its shape and integrity throughout the manufacturing process and during storage and transportation.

HPMC E3 also has excellent thickening properties, which make it useful as a suspending agent in liquid formulations. It helps to prevent settling of the active ingredient and other particles in the liquid, ensuring that the suspension remains homogeneous and uniform throughout the shelf life of the product.

Another important application of HPMC E3 in pharmaceuticals is its use as a sustained release agent. When used in this capacity, HPMC E3 helps to slow the release of the active ingredient from the tablet or capsule, allowing for a more controlled and gradual release over time. This is particularly important for medications that need to be released slowly and steadily over an extended period of time to maintain their therapeutic effect.

HPMC E3 is also used as a coating agent for tablets and capsules. When used in this capacity, it helps to protect the active ingredient from degradation by light, moisture, and other environmental factors, ensuring that the medication remains effective and stable throughout its shelf life. HPMC E3 coatings can also be used to mask the taste and odor of the active ingredient, making it more palatable for patients.

In addition to its use in tablets and capsules, HPMC E3 is also used in other pharmaceutical formulations, such as creams, gels, and ointments. In these formulations, it helps to improve the viscosity and texture of the product, making it easier to apply to the skin or other affected area. HPMC E3 is also used as a gelling agent in topical formulations, helping to form a gel-like consistency that provides a sustained release of the active ingredient.

The recommended dosage of HPMC E3 in pharmaceutical formulations varies depending on the specific application and the desired properties of the final product. Generally, a dosage of 1% to 5% of HPMC E3 based on the total weight of the formulation is recommended.