What are hard HPMC capsules?

Hard HPMC (Hydroxypropyl Methylcellulose) capsules are a type of vegetarian capsule commonly used in the pharmaceutical and nutraceutical industries for encapsulating solid or powdered substances such as drugs, dietary supplements, or herbal extracts. These capsules are also referred to as vegetarian capsules or cellulose capsules.

Here are some key features of hard HPMC capsules:

1. Vegetarian and Vegan-Friendly: Hard HPMC capsules are made from hydroxypropyl methylcellulose, which is derived from plant cellulose. As such, they are suitable for vegetarians and vegans, as they do not contain any animal-derived ingredients.
2. Gastric Acid Resistant: Hard HPMC capsules can be engineered to be resistant to gastric acid, ensuring that the capsule remains intact as it passes through the stomach and into the intestines. This property is particularly useful for encapsulating acid-sensitive substances or for targeted drug delivery to the intestines.
3. Moisture Stability: HPMC capsules have low moisture content and are less susceptible to moisture uptake compared to gelatin capsules. This can be advantageous for formulations that are sensitive to moisture or require extended shelf life.
4. Low Oxygen Permeability: Hard HPMC capsules have low oxygen permeability, which helps to protect encapsulated ingredients from oxidation and degradation over time.
5. Size Variety: HPMC capsules are available in various sizes to accommodate different dosages and fill volumes. They can be manufactured in sizes ranging from 000, the largest, to 5, the smallest.
6. Compatibility: Hard HPMC capsules are compatible with a wide range of formulations, including acidic, alkaline, and oily substances. They are also suitable for encapsulating hygroscopic or moisture-sensitive ingredients.
7. Customizable Properties: The properties of hard HPMC capsules, such as dissolution profile, moisture content, and gastric acid resistance, can be customized based on the specific requirements of the formulation or application.

hard HPMC capsules offer a vegetarian-friendly alternative to traditional gelatin capsules and are suitable for a variety of pharmaceutical and nutraceutical applications. They provide excellent compatibility, stability, and versatility for encapsulating a wide range of substances.