Hydroxypropyl methylcellulose uses in tablets

Hydroxypropyl methylcellulose (HPMC) is a common excipient used in pharmaceuticals, including tablets. HPMC is a cellulose-based polymer that is soluble in water and has a variety of properties that make it useful in tablet formulations. This article will discuss the properties of HPMC and its various uses in tablet manufacturing.

Properties of HPMC:

HPMC is a hydrophilic polymer that can be used as a binder, thickener, stabilizer, and emulsifier. It has a high molecular weight and a high degree of substitution (DS), which affects its solubility and viscosity. HPMC can be dissolved in water or alcohol, but it is not soluble in most organic solvents. It is also non-toxic, non-irritating, and non-allergenic, making it an ideal choice for pharmaceutical applications.

Uses of HPMC in tablets:

1. Binder:

HPMC is commonly used as a binder in tablet formulations. It is added to the tablet granules to hold them together and prevent them from falling apart. HPMC can be used alone or in combination with other binders, such as microcrystalline cellulose (MCC), to improve tablet hardness and friability.

2. Disintegrant:

HPMC can also be used as a disintegrant in tablet formulations. Disintegrants are added to tablets to help them break apart and dissolve quickly in the gastrointestinal tract. HPMC works as a disintegrant by swelling in water and creating channels for water to penetrate into the tablet. This helps to break apart the tablet and release the active ingredient.

3. Controlled release:

HPMC is used in controlled-release tablet formulations to regulate the release of the active ingredient. HPMC forms a gel layer around the tablet, which controls the release of the active ingredient. The thickness of the gel layer can be controlled by changing the DS of the HPMC, which affects the viscosity and solubility of the polymer.

4. Film-coating:

HPMC is also used as a film-coating agent in tablet formulations. Film-coating is the process of applying a thin layer of polymer to the tablet surface to improve its appearance, protect it from moisture, and mask its taste. HPMC can be used alone or in combination with other film-coating agents, such as polyethylene glycol (PEG), to improve the film-forming properties of the coating.

5. Suspension agent:

HPMC is also used as a suspension agent in liquid formulations. It can be used to suspend insoluble particles in a liquid to create a stable suspension. HPMC works by forming a protective layer around the particles, preventing them from agglomerating and settling to the bottom of the container.

Conclusion:

Hydroxypropyl methylcellulose is a versatile polymer that has a variety of uses in tablet formulations. It can be used as a binder, disintegrant, controlled-release agent, film-coating agent, and suspension agent. Its non-toxic, non-irritating, and non-allergenic properties make it an ideal choice for pharmaceutical applications. The properties of HPMC can be tailored by changing the degree of substitution, making it a flexible polymer that can be used in a variety of tablet formulations.