HPMC Hypromellose

Hydroxypropyl Methylcellulose (HPMC), is a versatile chemical compound with the formula [C6H7O2(OH)3-m-n(OCH3)m(OCH2CH(OH)CH3)n]x, where m represents the degree of methoxy substitution and n represents the degree of hydroxypropoxy substitution. It is derived from cellulose, a natural polymer obtained from the cell walls of plants. HPMC is odorless, tasteless, and non-toxic. It has various physicochemical properties such as solubility in water, thermal gelation properties, and the ability to form films, making it widely used across multiple industries.

In the pharmaceutical industry, HPMC is extensively used as an excipient—a substance formulated alongside the active ingredient of a medication, for the purpose of long-term stabilization, bulking up solid formulations that contain potent active ingredients in small amounts (thus often referred to as a filler, diluent, or carrier), or to enhance absorption or solubility. HPMC capsules are an alternative to gelatin capsules for vegetarians and are used in controlled-release formulations, allowing for the slow release of a drug over time. HPMC solutions can also serve as viscolyzers to increase the viscosity of ophthalmic solutions, improve bioadherence, and prolong the residence time of drugs on the ocular surface.

In the food industry, HPMC is recognized as a safe food additive (E464) and serves multiple functions such as an emulsifier, thickening agent, and stabilizer. It is employed in the production of a variety of foods to improve texture, retain moisture, and form edible films. The thermal gelation property of HPMC is particularly valuable in applications requiring gelling at specific temperatures, such as in vegetarian and vegan recipes where it can substitute for gelatin. HPMC also contributes to the shelf life and quality of baked goods, sauces, and desserts by controlling crystallization and moisture.

The construction industry benefits from HPMC in the manufacture of building materials. Its applications include acting as a binder and water retention agent in mortars, plasters, and coatings, improving workability, reducing water usage, and extending open time – the period during which a material remains usable. HPMC enhances the properties of cement-based formulations, providing better adhesion, spreadability, and resistance to sagging.

In the cosmetics and personal care industry, HPMC serves as a film-forming agent, emulsifier, and rheology modifier in products such as lotions, creams, and hair gels. Its compatibility with various skin types and ability to stabilize emulsions enhance product performance and longevity. HPMC’s hydration properties make it a desirable ingredient inskin care products, helping to retain moisture and providing a smooth feel. In summary, HPMC’s versatility spans pharmaceuticals, food, construction, and cosmetics, highlighting its importance as a multifunctional ingredient in various applications.