Ko te Hydroxypropyl methyl cellulose HPMC he ahua o te cellulose kore-ionic i konatunatua ether, he rereke mai i te katote methyl carboxymethyl cellulose i konatunatua ether, a kaore e pa ki nga konganuku taumaha. Na te rereke o nga rereketanga o te ihirangi methoxyl me te ihirangi hydroxypropyl i roto i te hydroxypropyl methylcellulose me nga rereke rereke, kua waiho hei momo momo rereke me nga ahuatanga rereke, hei tauira, te nui o te methoxyl me te iti o te waikawa hydroxypropyl Ko tana mahi he tata ki te methyl cellulose, a nga momo he iti te ihirangi methoxyl me te ihirangi hydroxypropyl teitei, he tata te mahi ki tera o te hydroxypropyl methylcellulose. Heoi, i roto i nga momo momo, ahakoa he iti noa te roopu hydroxypropyl, he roopu methoxy iti ranei kei roto, he tino rerekee te whakarewatanga i roto i nga whakarewa pararopi, te pāmahana karekau ranei i roto i te wairewa wai.
1. Te memehatanga o te hydroxypropyl methylcellulose
①Ko te wairewa o te hydroxypropyl methyl cellulose i roto i te wai Ko te Hydroxypropyl methyl cellulose he methyl cellulose i whakarereketia e te propylene oxide (methyl oxypropylene), no reira he rite tonu nga ahuatanga ki te methyl cellulose. He rite te Cellulose ki te wairewa matao me te wai wera. Heoi, na te roopu hydroxypropyl kua whakarereketia, he nui ake te pāmahana o te wai wera i tera o te methyl cellulose. Hei tauira, ko te viscosity o te wairewa wai o te hydroxypropyl methylcellulose me te 2% methoxyl content DS=0.73 me te ihirangi hydroxypropyl MS=0.46 he 500 mpa?s i te 20°C. Ko tona pāmahana reera Ka tata ki te 100°C, ko te methylcellulose i te taurite he 55°C noa iho. Mo tona memehatanga ki te wai, kua tino pai ake. Hei tauira, ka taea te whakamahi i te hydroxypropyl methylcellulose (te ahua o te 0.2~0.5mm i te 20°C me te pokey o te 4% wairewa wai tae atu ki te 2pa?s i roto I te pāmahana rūma, he ngawari te whakarewa i roto i te wai me te kore e whakamatao.
②Ko te whakarewatanga o te hydroxypropyl methyl cellulose i roto i nga whakarewa waro Ko te whakarewatanga o te hydroxypropyl methyl cellulose i roto i nga whakarewa pararopi he pai ake i tera o te methyl cellulose, me te methyl cellulose me whai tohu whakakapi methoxyl i nga Hua i runga ake i te 2.1, me te hydroxypropyl teitei kei roto i te methylcellulose. hydroxypropyl MS=1.5~1.8 me te methoxy DS=0.2~1.0, me te katoa o te tohu whakakapinga i runga ake i te 1.8 ka whakarewahia i roto i te methanol anhydrous me te wairewa wairewa reo, thermoplastic me te wai-wairewa. He wairewa ano i roto i te waiwaro maota penei i te dichloromethane me te chloroform, me nga whakarewa pararopi penei i te acetone, isopropanol me te waipiro diacetone. He pai ake te whakarewatanga o te wairewa i te wairewa.
2. Nga mea e pa ana ki te pokey o te hydroxypropyl methylcellulose
Te awe i nga ahuatanga o te viscosity hydroxypropyl methyl cellulose Ko te whakatau i te viscosity paerewa o te hydroxypropyl methyl cellulose, pera i etahi atu etera cellulose, he mea hanga i runga i te wairewa wai 2% i te 20°C. Ko te pokey o taua hua ka piki ake me te piki o te kukū. Mo nga hua he rereke nga taumahatanga ngota i te kukū kotahi, ko nga hua he nui ake te taumahatanga ngota he nui ake te pokey. Ko tona hononga ki te pāmahana he rite ki te methyl cellulose. Ka piki ake te pāmahana, ka timata te heke o te pokey, engari ka tae ki tetahi pāmahana, ka piki ohorere te pokey, ka puta te wai. He teitei ake te mahana o te reera o nga hua iti-viscosity. he tiketike. Ko tana tohu gel ehara i te mea e pa ana ki te viscosity o te ether anake, engari ki te hanganga o te methoxy me te hydroxypropyl i roto i te ether me te tohu katoa o te whakakapi. Me tohu ko te hydroxypropyl methylcellulose he pseudoplastic hoki, a, ka pumau tana otinga i te pāmahana rūma kaore he paheketanga o te pokey engari ko te tupono o te whakahekenga enzymatic.
3. Hydroxypropyl methylcellulose acid and alkali resistance
Hydroxypropyl methylcellulose acid and alkali resistance Hydroxypropyl methylcellulose is commonly stable to acid and alkali, and is not affect in the range of pH 2~12. Ka taea e ia te tu atu ki te nui o te waikawa marama. Pērā i te waikawa formic, te waikawa acetic, te waikawa citric, te waikawa succinic, te waikawa phosphoric, te waikawa boric, me etahi atu. Heoi, ko te waikawa kukū te hua o te whakaiti i te pokey. Karekau he painga ki runga i te Alkali, penei i te houra, te hoha, me te wai kotakota, engari ka piki ake te pokey o te otinga, katahi ka puta he ahua o te heke puhoi a muri ake nei.
4. Te whakakotahitanga o te hydroxypropyl methylcellulose
Ka taea te whakauru i te wairewa Hydroxypropyl Methyl Cellulose Hydroxypropyl methyl cellulose ki te wai-wairewa polymer pūhui kia noho rite, kia marama te otinga me te pokey teitei ake. Ko enei pūhui polymer ko te polyethylene glycol, polyvinyl acetate, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl cellulose me te methyl cellulose. He pai te whakakotahitanga o nga puhui polymer penei i te kapia arabic, te kapia mawhitiwhiti, te kapia karaya, me etahi atu. Ko te Hydroxypropyl methylcellulose ka taea ano te whakauru ki te mannitol me te sorbitol esters o te waikawa stearic, te waikawa palmitic ranei, ka taea hoki te whakauru ki te glycerin, sorbitol me te mannitol. Ka taea te whakamahi i enei pūhui hei hydroxypropyl methylcellulose. Te whakakikorua i runga i te cellulose.
5. Korekore me te wairewa o te hydroxypropyl methylcellulose
Ko nga etera cellulose wairewa-wairewa o te hydroxypropyl methylcellulose ka taea te hono-mata ki te aldehydes, a ko enei etera wairewa-wai ka whakahekehia i roto i te otinga ka kore e rewa ki te wai. Ko nga aldehydes e hanga ana i te hydroxypropyl methylcellulose kia kore e rewa ko formaldehyde, glyoxal, succinaldehyde, adipaldehyde, me etahi atu. Ina whakamahi formaldehyde, me aro nui ki te uara pH o te otinga, kei roto ko te glyoxal te tere tere. Na reira, ka whakamahia te glyoxal hei kaihoko whakawhiti i roto i nga mahi ahumahi. Ko te inenga o tenei momo kaihoko whakawhiti i roto i te otinga ko te 0.2% ~ 10% o te papatipu ether, he pai ki te 7% ~ 10%, me te 3.3% ~ 6% te mea tino pai mo te glyoxal. Ko te pāmahana maimoatanga whānui ko 0 ~ 30 ℃, me te wa ko 1 ~ 120min. Me whakahaere te tauhohenga honohono i raro i nga tikanga waikawa. Ko te tikanga, ka taapirihia te waikawa kaha pararopi, te waikawa carboxylic waro ranei ki te otinga hei whakatika i te pH o te otinga ki te 2~6, he pai ake i waenga i te 4~6, katahi ka taapirihia nga aldehydes hei kawe i te tauhohenga whakawhiti. . Ko nga waikawa e whakamahia ana ko te waikawa waikawa, te waikawa sulfuric, te waikawa phosphoric, te waikawa formic, te waikawa acetic, te waikawa hydroxyacetic, te waikawa succinic, te waikawa citric ranei, i roto i nga mea e tika ana te waikawa formic, waikawa acetic ranei, ko te waikawa formic te mea tino pai. Ka taea hoki te taapiri i te waikawa me te aldehyde i te wa kotahi kia taea ai e te otinga te hono whakawhiti ki te awhe pH e hiahiatia ana. Ka whakamahia tenei tauhohenga i roto i te tukanga maimoatanga whakamutunga i roto i te whakaritenga o nga eter cellulose. I muri i te insolubilized te cellulose ether, he pai ki te horoi me te purea ki te wai i te 20 ~ 25 ° C. I te wa e whakamahia ana te hua, ka taea te taapiri i tetahi matū kawakore ki te otinga o te hua hei whakatika i te pH o te otinga kia kawakore, ka tere te memeha o te hua ki te otinga. Ka pa ano tenei tikanga ki te otinga cellulose ether i hangaia hei kiriata katahi ka tukatukahia te kiriata kia waiho hei kiriata korekore.
6. He ātete te Hydroxypropyl methylcellulose ki te whākōkī
He ātete te Hydroxypropyl methylcellulose ki te whākōkī. I roto i te ariā, ko nga hua o te cellulose, penei i ia roopu anhydroglucose, he roopu whakakapi e mau ana, ehara i te mea ngawari ki te pangia e nga microorganisms, engari ko te mea kua oti te hua Ina neke atu te uara whakakapinga ki te 1, ka whakahekehia ano e nga enzymes, Ko te tikanga ko te tohu o te whakakapinga o ia roopu i runga i te mekameka cellulose kaore i te tino rite, ka taea e nga microorganisms te horo tata ki nga roopu anhydroglucose kore whakakapi ki te hanga huka. , ka horohia hei matūkai mo nga microorganisms. Na reira, ki te piki te tohu whakakapinga whakaeera o te cellulose, ka whakanuia ano te aukati ki te horo enzymatic o te cellulose ether. E ai ki te korero ko te toenga viscosity o te hydroxypropyl methylcellulose (DS=1.9) he 13.2%, ko te methylcellulose (DS=1.83) he 7.3%, ko te methylcellulose (DS=1.66) he 3.8%, ko te hydroxyethyl cellulose he 1.7%. Ka kitea he kaha te kaha anti-enzyme o te hydroxypropyl methylcellulose. Na reira, ko te tino pai o te aukati o te haurangi o te hydroxypropyl methylcellulose, me te pai o te whakamararatanga, te matotoru me te hanga kiriata, kei te whakamahia i roto i nga paninga wai-emulsion, me etahi atu, me te nuinga o te waa kaore e hiahiatia te taapiri o nga rongoa. Engari, mo te wa roa mo te rokiroki o te otinga, te poke ranei o te ao o waho, ka taea te taapiri i nga rongoa hei whakatupato, a ka taea te whakatau i te whiringa i runga i nga whakaritenga whakamutunga o te otinga. Ko te Phenylmercuric acetate me te manganese fluorosilicate he rongoa whai hua, engari kei a raua te Toxicity, me aro ki te mahi, a ko te waahanga ko te 1 ~ 5mg o te acetate phenylmercuric ia rita o te otinga.
7. Nga ahuatanga o te kiriata hydroxypropyl methylcellulose
Ko te mahinga o te kiriata hydroxypropyl methylcellulose Hydroxypropyl methylcellulose he tino pai nga ahuatanga o te hanga kiriata, a, ko tana otinga wai, he otinga whakarewa pararopi ranei ka pania ki runga i te pereti karaihe, ka kore te tae me te marama i muri i te whakamaroketanga. Me te kiriata uaua. He pai te aukati makuku me te pumau tonu i nga wera teitei. Hei tauira, ka taea e te taapiri i te whakahiato hygroscopic te whakaroa me te ngawari. Hei whakapai ake i te ngawari, ko nga kaiparapara penei i te glycerin me te sorbitol te mea tino pai. Ko te kukū otinga whānui ko 2% ~ 3%, me te nui o te plasticizer ko 10% ~ 20% o te cellulose ether. Mena he tiketike rawa te ihirangi o te plasticizer, ka puta te ahua whakaheke o te whakamaroketanga colloid i raro i te makuku nui. Ko te kaha tensile o te kiriata me te plasticizer taapiri he nui ake i tera kaore he kirihou, ka piki ake ki te piki o te moni taapiri. Mo te hygroscopicity o te kiriata, ka piki ake ano me te piki o te nui o te plasticizer.
Wā tuku: Oketopa-13-2022