Ko te Hydroxypropyl methylcellulose HPMC he cellulose kore-katote i konatunatua ether i roto i nga momo etere whakauru me te katote methylcarboxymethylcellulose. Kare e aro ki nga konganuku taumaha. Ko nga rereketanga o te ihirangi o te hydroxypropyl methylcellulose, hydroxypropyl methylcellulose, me te ōwehenga ihirangi hydroxypropyl me te viscosity o te ira hāora kore he momo rerekee i runga i te mahi. Hei tauira, he rereke te mahinga o nga momo methoxyl teitei me te iti o te hydroxypropyl. Tata ki te methylcellulose me nga momo ihirangi methoxy iti. Ka whakatauritea ki nga momo he nui ake te ihirangi hydroxypropyl, he tata te mahi o te hydroxypropyl methylcellulose i hangaia. Heoi, ahakoa he iti noa iho te roopu hydroxypropyl, he roopu methoxy iti ranei kei roto i ia momo, he nui nga rereketanga o te whakarewatanga i roto i nga whakarewa pararopi, i te pāmahana karekau ranei i roto i nga wairewa wai.
1. Te wairewa o te hydroxypropyl methylcellulose
Te wairewa o te hydroxypropyl methylcellulose i roto i te wai Ko te Hydroxypropyl methylcellulose he propylene oxide (methylhydroxypropyl ring) kua whakarereketia te methylcellulose, no reira he rite tonu nga ahuatanga ki te methylcellulose He rite nga ahuatanga o te whakarewa ki te wai makariri engari karekau i te wai wera. Heoi ano, he teitei ake te pāmahana reera o te hydroxypropyl whakarereke i roto i te wai wera i tera o te methylcellulose. Hei tauira, ko te 2% hydroxypropyl methylcellulose wairewa wai me te methoxy group content DS=0.73 me te hydroxypropyl group content MS=0.46 he 500mpa i te 20°C. He tata ki te 100°C te mahana o te reera o te hua S, i te mea ko te methylcellulose i te taurite ano he 55°C noa iho. Mo tona memehatanga ki te wai, kua tino pai ake. Hei tauira, i muri i te pakaru o te hydroxypropyl methylcellulose (ko te ahua matūriki ko 0.2 ~ 0.5mm, ko te pokey o te 4% te wai i te 20 ° C ko 2pA · S, ka taea te whakamahi i te pāmahana rūma me te kore e whakamatao. Ka memeha noa ki te wai).
(2) Te whakarewatanga o te hydroxypropyl methylcellulose i roto i nga whakarewa pararopi He pai ake hoki te whakarewatanga o te hydroxypropyl methylcellulose i roto i nga whakarewa pararopi i to te methylcellulose. Ko te Methylcellulose e hiahia ana ki te tohu whakakapinga methoxy o 2.1 Ko nga hua o runga ake kei roto i te hydroxypropyl methylcellulose teitei-nui me te hydroxypropyl MS = 1.5 ~ 1.8 me te methoxy DS = 0.2 ~ 1.0, me te tohu whakakapi katoa o te neke atu i te 1.8, a he ngawari te whakarewa i roto i te methanol anhydrous. rongoā waihā. Thermoplastic me te wai-wairewa. He wairewa ano i roto i te waiwaro chlorinated penei i te methylene chloride me te chloroform, me nga whakarewa pararopi penei i te acetone, te waipiro isopropyl me te waipiro diacetone. He pai ake te whakarewatanga o te wairewa i te wairewa.
2. Nga mea e pa ana ki te pokey o te hydroxypropyl methylcellulose
Hydroxypropyl methylcellulose viscosity factor He rite tonu te inenga pokey paerewa o te hydroxypropyl methylcellulose ki etahi atu ether cellulose, ka ine ki te 20°C me te 2% wairewa wai hei paerewa. Ka piki ake te viscosity o taua hua ka piki ake te kukū. Mo nga hua he rite te kukū me nga taumahatanga ngota rereke, ko te hua he nui ake te taumaha ngota he nui ake te pokey. Ko tona hononga ki te pāmahana he rite ki te methylcellulose. Ka piki ake te pāmahana, ka timata te heke o te pokey, engari ka tae ki tetahi pāmahana, ka piki ohorere te pokey ka puta te wai. Ko nga hua pokey iti he teitei ake te pāmahana whakaraera i nga hua pokey teitei. Ko te tohu gel e kore e pa ana ki te viscosity o te ether anake, engari e pa ana ki te hanganga o nga roopu methoxy me te hydroxypropyl i roto i te ether me te tohu katoa o te whakakapi. Me tohu ko te hydroxypropyl methylcellulose he pseudoplastic hoki; ka pumau ana otinga ina rongoa ki te pāmahana rūma, karekau hoki e whakaatu te heketanga o te pokey, engari mo te paheketanga o te enzymatic.
3. Ko te Hydroxypropyl methylcellulose he waikawa me te kawakore
Ko te Hydroxypropyl methylcellulose he waikawa me te kawakore. Ko te Hydroxypropyl methyl cellulose he waikawa me te kawakore. Ko te tikanga pūmau me te kore e pa ki te uara pH i roto i te awhe o PH2~12. Ka taea e ia te tu ki etahi momo waikawa ngoikore, penei i te waikawa formic, waikawa acetic, me te rēmana. Ko te waikawa, te waikawa succinic, te waikawa phosphoric engari ko te waikawa kukū te hua o te whakaiti i te pokey. Karekau he painga ki runga i te wai kawa, penei i te houra, te pāhare pāporo, me te wai kotakota, engari ko te hua o te whakanui paku te pokey o te otinga ka heke haere i muri mai.
4. Ka taea te whakauru Hydroxypropyl methylcellulose
Ka taea te whakakotahi i te wairewa Hydroxypropyl methylcellulose ki nga pūhui polymer wairewa-wai hei hanga i te otinga rite me te maamaa me te pokey teitei ake. Ko enei pūhui polymer ko te polyethylene glycol, polyvinyl acetate, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl cellulose me te methyl cellulose. He pai te whakakotahitanga o nga puhui polymer maori penei i te kapia acacia, te kapia mawhitiwhiti, te kapia mawhitiwhiti, me etahi atu. tona otinga. Ko te Hydroxypropyl methylcellulose ka taea ano te whakauru ki te waikawa stearic, te mannitol palmitate ranei te sorbitol, ka taea hoki te whakauru ki te glycerin, sorbitol me te mannitol. Ka taea te whakamahi i enei pūhui hei kaihoko kirihou hydroxypropyl methylcellulose.
5. Ko te Hydroxypropyl methylcellulose he kore e rewa ki te wai
Ko te Hydroxypropyl methylcellulose he kore e rewa i roto i te wai-wairewa cellulose ethers, a ka taea te hono-whakawhiti ki te mata ki te aldehydes, na enei etera wairewa-wai ka tohe i roto i te otinga ka kore e rewa ki te wai. Me hanga hydroxypropyl methylcellulose kia kore e rewa i roto i te aldehydes, formaldehyde, glyoxal, succinic acid, dialdehyde, me etahi atu. Ina whakamahi formaldehyde, me aro nui ki te uara pH o te otinga. I roto i a raatau, he tere te urupare a glyoxal, no reira ka whakamahia i roto i te umanga Ko te Glyoxal te nuinga o te whakamahi hei kaihoko honohono i roto i te hanga. -Kaiwhakawhiti hononga. Ko te inenga o tenei momo kaihoko whakawhiti i roto i te otinga ko te 0.2% ki te 10% o te papatipu o te ether, a ko te mea pai ko te 7% ki te 10%. Mena ka whakamahia te glyoxal, 3.3% ki te 6% te mea tino pai. Ko te pāmahana maimoatanga whānui ko 0 ~ 30 ℃ me te wa ko 1 ~ 120min. Me whakahaere te tauhohenga honohono i raro i nga tikanga waikawa. Ko te tikanga, ka taapirihia te waikawa kaha pararopi, te waikawa waroparaka waro ranei ki te otinga hei whakatika i te pH o te otinga ki te 2 ki te 6, he pai ake i waenga i te 4 me te 6, katahi ka taapirihia nga aldehydes hei mahi i te tauhohenga honohono. Ko nga waikawa e whakamahia ana ko te waikawa waikawa, te waikawa sulfuric, te waikawa phosphoric, te waikawa formic, te waikawa acetic, te waikawa glycolic, te waikawa succinic, te waikawa citric ranei, i roto i enei ko te waikawa formic, waikawa acetic ranei te mea pai, ko te waikawa formic te mea pai. Ka taea hoki te taapiri i te waikawa me te aldehydes i te wa kotahi ki te hono i te otinga i roto i te awhe pH e hiahiatia ana. He maha nga wa e whakamahia ana tenei tauhohenga i roto i te waahanga whakamutunga o te tukanga whakarite cellulose ether kia kore ai e rewa te cellulose ether me te whakahaere i te horoi me te purenga ki te wai 20~25°C. I te wa e whakamahi ana koe i te hua, ka taea e koe te taapiri i nga matū kawakore ki te otinga hua hei whakatika i te pH o te otinga kia kawakore kia tere ai te memeha o te hua i roto i te otinga. Ka taea hoki te whakamahi i tenei tikanga ina rerihia he kiriata ma te whakamahi i te otinga cellulose ether katahi ka tukatukahia te kiriata ki te kiriata korekore.
6. Hydroxypropyl methylcellulose anti-enzyme
Ko nga pärönaki cellulose o te hydroxypropyl methylcellulose he aatete ki nga enzymes. Hei tauira, ko ia roopu anhydroglucose e tino herea ana ki tetahi roopu whakakapi, a, kare e whakaraerae ki te horo microbial me te mate. Heoi ano, ko te uara whakakapinga o te hua kua oti kua neke ake i te 1. Ka taea hoki te whakaheke e nga enzymes, e whakaatu ana ko te tohu o te whakakapinga o ia roopu i roto i te mekameka cellulose he koretake, a ka taea e nga microorganisms te whakakore i nga roopu anhydroglucose tata tata ki te hanga. te huka, ka taea e nga microorganisms hei kai. Na reira, ki te piki te tohu o te whakakapinga ether o te cellulose, ka piki ake te aukati o nga eter cellulose ki te whakaeke enzymatic. E ai ki nga korero i raro i nga tikanga whakahaere, hydroxypropyl methylcellulose (DS=1.9), methylcellulose (DS=1.83), methylcellulose (DS=1.66), hydroxyethylcellulose (1.7%) Ko te toenga viscosities he 13.2%, 7.3%, 3.8% me te 1.7% ia. Ko te Hydroxypropyl methylcellulose he kaha ki te aukati i te hauhau. Ka kitea ko te hydroxypropyl methylcellulose he tino pai te aukati i te whaa, me te pai o te whakamararatanga, te matotoru me te hanga kiriata, ka taea te whakamahi i roto i nga paninga whakaehunga, me etahi atu, me te nuinga kaore e hiahiatia te taapiri o nga rongoa. Engari, hei aukati i te otinga mai i te rokiroki mo te wa roa, ka taea ranei te poke o waho, ka taea te taapiri i nga rongoa, a ka taea te whakatau i te kowhiringa o nga rongoa i runga i nga whakaritenga whakamutunga o te otinga. Ko te Phenylmercuric acetate me te manganese fluorosilicate he rongoa whai hua, engari he paitini, me ata whakahaere. Ko te tikanga, 1 ki te 5 mg o te acetate phenylmercuric ka taea te taapiri ki ia rita o te otinga.
7. Mahinga o te membrane hydroxypropyl methylcellulose
Hydroxypropyl methylcellulose āhuatanga hanga kiriata Hydroxypropyl methylcellulose He pai rawa nga ahuatanga hanga kiriata. Ka whakakikoruatia tana wairewa wai, wairewa whakarewa pararopi ranei ki runga i te pereti karaihe, ka waiho hei kiriata kore tae, marama me te uaua i muri i te whakamaroketanga. . He pai te aukati makuku me te pumau tonu i nga wera teitei. Mena ka taapirihia nga kirihou hygroscopic, ka taea te whakaroa me te ngawari, ka taea te whakapai ake. Ko nga kaiparapara penei i te glycerol me te sorbitol te mea tino pai. Ko te kukū otinga whānui ko 2% ~ 3%, me te inenga plasticizer ko 10% ~ 20% o te etera cellulose. Ki te hiahiatia te ihirangi plasticizer ki te kia tiketike, ka puta colloid syneresis i raro i te haumākū tiketike. Ko te kaha tensile o te kiriata me te plasticizer kua tapiritia he nui ake i tera o te kiriata kaore he kirihou, a ka piki ake ki te nui o te plasticizer kua tapiritia. Ka piki hoki te hygroscopicity o te kiriata ki te nui o te plasticizer.
Wā tuku: Feb-01-2024