Hydroxypropyl methylcellulose (HPMC) bụ ihe pụrụ iche nke a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ, nri na ịchọ mma. Nke a na-enweta cellulose sitere na cellulose eke ma gbanwee iji nweta ihe ndị a kapịrị ọnụ, na-eme ka ọ bụrụ ihe dị mkpa n'ụdị dị iche iche.
1. Okwu Mmalite nke Hydroxypropyl Methylcellulose (HPMC)
1.1. Ọdịdị chemical na Njirimara
Hydroxypropylmethylcellulose bụ polymer synthetic nke na-enweta site na cellulose, bụ isi ihe nhazi nke mgbidi cell osisi. Usoro kemịkalụ nke HPMC nwere akụkụ ọkpụkpụ azụ cellulose jikọtara na otu hydroxypropyl na methyl. Ogo nke nnọchi nke otu ndị a na-emetụta solubility, viscosity, na ihe ndị ọzọ anụ ahụ nke polymer.
HPMC na-adịkarị ọcha ma ọ bụ na-acha ọcha n'ọdịdị, enweghị isi na enweghị ụtọ. Ọ na-agbaze na mmiri ma na-emepụta ihe ngwọta doro anya, viscous, na-eme ka ọ baa uru na ngwa dị iche iche.
1.2. Usoro nrụpụta
Mmepụta nke hydroxypropyl methylcellulose gụnyere etherification nke cellulose site na iji propylene oxide na methyl chloride. Usoro a na-agbanwe ìgwè hydroxyl na agbụ cellulose, na-eduga n'ịmepụta hydroxypropyl na methyl ether otu. Ịchịkwa ogo nke nnọchi n'oge usoro nrụpụta na-enyere aka ịhazi akụrụngwa HPMC.
2. Njirimara anụ ahụ na nke kemịkal
2.1. Solubility na viscosity
Otu n'ime ihe ndị bụ isi nke HPMC bụ solubility ya na mmiri. Ọnụego mgbasa na-adabere n'ogo nke nnọchi na ịdị arọ molekụla. Omume solubility a na-eme ka ọ dị mma maka usoro dị iche iche na-achọ ntọhapụ a na-achịkwa ma ọ bụ nhazi gel.
The viscosity nke HPMC ngwọta bụkwa mgbanwe, sitere na ala ruo elu viscosity akara ule. Ngwongwo a dị oke mkpa maka ịhazi njirimara rheological nke usoro dị ka ude, gels na ngwọta ophthalmic.
2.2. Ịrụpụta ihe nkiri
A maara HPMC maka ikike imepụta ihe nkiri, na-eme ka ọ bụrụ ihe dị mma maka mbadamba mkpuchi na granules. Ihe nkiri a na-esi na ya pụta bụ nke doro anya ma na-agbanwe agbanwe, na-enye mkpuchi nchebe maka ihe na-emepụta ọgwụ na-arụ ọrụ (API) na ịkwalite ntọhapụ a na-achịkwa.
2.3. Nkwụsi ike okpomọkụ
Hydroxypropyl methylcellulose nwere ezigbo nkwụsi ike nke okpomọkụ, na-enye ya ohere iguzogide ọnọdụ okpomọkụ dị iche iche na-ezute n'oge mmepụta ihe. Ihe onwunwe a na-eme ka mmepụta nke ụdị usoro onunu ogwu siri ike, gụnyere mbadamba na capsules.
3. Ngwa nke hydroxypropyl methylcellulose
3.1. Ụlọ ọrụ ọgwụ
A na-eji HPMC eme ihe n'ọtụtụ ebe n'ọhịa ọgwụ dị ka ihe na-emepụta mbadamba mbadamba ma nwee ọtụtụ ojiji. Ọ na-arụ ọrụ dị ka ihe nkedo, na-achịkwa nkwụsịtụ na ntọhapụ nke ihe ndị na-arụ ọrụ. Tụkwasị na nke ahụ, ihe ndị na-emepụta ihe nkiri ya na-eme ka ọ dị mma maka mbadamba mkpuchi iji nye oyi akwa mkpuchi.
N'ime usoro mmiri ọnụ ọnụ, enwere ike iji HPMC dị ka onye na-akwụsịtụ, thickener, ma ọ bụ iji dozie viscosity. Ojiji ya na ngwọta ophthalmic bụ ihe ama ama maka njirimara mucoadhesive ya, nke na-emezi bioavailability anya.
3.2. Ụlọ ọrụ nri
Ụlọ ọrụ nri na-eji HPMC eme ihe dị ka ihe na-esi ísì na gelling na ngwaahịa dị iche iche. Ikike ya ịmepụta gels doro anya na njikwa viscosity na-eme ka ọ baa uru na ngwa dị ka sauces, uwe na ihe oriri. A na-ahọrọ HPMC n'ọtụtụ ebe a na-emepụta ihe n'ọdịnala n'ihi na ọ na-enwe mmetụta dị iche iche na njirimara anụ ahụ nke ngwaahịa nri.
3.3. Ihe ịchọ mma na ngwaahịa nlekọta onwe onye
N'ụdị ihe ịchọ mma, a na-eji HPMC eme ihe maka ịgbatị, nkwụsi ike na imepụta ihe nkiri. A na-ahụkarị ya na ude, lotions, na ngwaahịa nlekọta ntutu isi. Ikike polymer iji meziwanye udidi na nkwụsi ike nke usoro nhazi na-enye aka n'iji ya eme ihe na ụlọ ọrụ ịchọ mma.
3.4. Ụlọ ọrụ ihe owuwu
A na-eji HPMC eme ihe na ụlọ ọrụ ihe owuwu dị ka ihe na-ejigide mmiri maka ụrọ simenti na ihe ndị dabeere na gypsum. Ọrụ ya bụ ịkwalite nhazi nhazi, gbochie mgbawa, na melite adhesion.
4. Usoro nchịkwa na profaịlụ nchekwa
4.1. Ọkwa nchịkwa
A na-amatakarị Hydroxypropyl methylcellulose dị ka nchekwa (GRAS) site n'aka ụlọ ọrụ nhazi dịka US Food and Drug Administration (FDA) na European Food Safety Authority (EFSA). Ọ na-ezute ụkpụrụ ọgwụ dị iche iche ma depụta ya na monographs nke ha.
4.2. Nyochaa nchekwa
Dị ka ihe a na-ejikarị eme ihe, HPMC nwere profaịlụ nchekwa dị mma. Otú ọ dị, ndị mmadụ n'otu n'otu nwere ihe nfụkasị ahụ na-emepụta cellulose kwesịrị ịkpachara anya. A na-ahazi ntinye nke HPMC na usoro ahụ iji hụ na nchekwa, nke dị oke mkpa maka mmadụ. Ndị na-emepụta ihe na-agbaso ụkpụrụ nduzi.
5. Mmechi na atụmanya n'ọdịnihu
Hydroxypropyl methylcellulose apụtala dị ka ihe pụrụ iche nwere ọtụtụ ngwa na ụlọ ọrụ ọgwụ, nri, ịchọ mma na ụlọ ọrụ ihe owuwu. Ngwakọta ya pụrụ iche nke solubility, njikwa viscosity na ihe ndị na-emepụta ihe nkiri na-eme ka ọ bụrụ ihe bara uru n'ọtụtụ nhazi.
Nnyocha na mmepe na-aga n'ihu na ngalaba sayensị polymer nwere ike iduga n'ihu ọganihu na arụmọrụ HPMC iji gboo mkpa ụlọ ọrụ dị iche iche. Ka ọchịchọ maka usoro mwepụta a na-achịkwa na mmepe ngwaahịa ọhụrụ na-aga n'ihu na-eto, hydroxypropyl methylcellulose nwere ike ịnọgide na-arụ ọrụ ya ama ama dị ka ihe na-akpali akpali.
Oge nzipu: Jan-15-2024