Hydroxypropyl methylcellulose (HPMC) bụ ihe polymer a na-ejikarị na nkwadebe ọgwụ. N'ihi ọmarịcha anụ ahụ na kemịkal ya, ọ na-arụ ọrụ dị mkpa n'ichepụta mbadamba nkume. Enwere ike iji HPMC dị ka ihe nkiri mbụ, onye nrụpụta a na-achịkwa, nrapado, thickener, wdg, na-enye mbadamba ihe nhazi na ọrụ dị mma.
1. Ihe nkiri mbụ
Ọrụ HPMC dị ka ihe nkiri mbụ na-egosipụtakarị na mkpuchi elu nke mbadamba ihe ntọhapụ a na-achịkwa. A na-eme mkpuchi mbadamba mbadamba maka ebumnuche ịchịkwa ọnụego ntọhapụ nke ọgwụ, na-echebe ọgwụ site na mmetụta gburugburu ebe obibi, na imeziwanye ọdịdị ọgwụ. N'ime nkwadebe ntọhapụ a na-achịkwa, ihe nkiri nke HPMC guzobere nwere ike gbanwee ọnụego ntọhapụ nke ọgwụ, hụ na a na-ewepụta ọgwụ ndị ahụ n'akụkụ ụfọdụ nke eriri afọ, ma nweta mmetụta ọgwụgwọ kachasị mma.
Usoro nke ime ihe: Ihe nkiri ahụ nke ihe nkiri HPMC mere na mbụ nwere ike nweta ntọhapụ nke ọgwụ na-achịkwa site na ịchịkwa ntinye nke ihe mgbaze na nkwụsị nke ọgwụ. Ọkpụrụkpụ na ihe mejupụtara ihe nkiri ahụ nwere ike gbanwee ọnụego mgbasa iji zute ihe ntọhapụ nke ọgwụ dị iche iche.
Mmetụta: Mbadamba ụrọ na-eji HPMC dị ka onye na-emepụta ihe nkiri nwere ike ịgbaze nwayọọ nwayọọ n'ime afọ, zere ịhapụ ọgwụ ọjọọ na mberede, melite iji ọgwụ eme ihe, ma belata iwe ọgwụ na tract gastrointestinal.
2. Onye ntọhapụ na-achịkwa
A na-ejikarị HPMC eme ihe dị ka ihe matriks na mbadamba ihe a na-achịkwa iji chịkwaa ọnụego ntọhapụ nke ọgwụ site n'ịme mgbochi gel. Ọrụ nke onye ntọhapụ na-achịkwa bụ iji hụ na a na-ewepụta ọgwụ ahụ n'otu oge n'ime oge a kapịrị ọnụ iji nọgide na-enwe mmetụta dị mma nke ọgwụ ahụ n'ime ahụ, belata ọnụ ọgụgụ nke oge doses, ma melite nnabata onye ọrịa.
Usoro nke ime ihe: Na mgbasa ozi aqueous, HPMC nwere ike mee ngwa ngwa hydrate wee mepụta usoro netwọkụ colloidal, nke na-achịkwa mgbasa na ntọhapụ nke ọgwụ. Mgbe mbadamba nkume ahụ na-abanye na mmiri, HPMC na-amịkọrọ mmiri ma zaa iji mepụta akwa gel, site na nke ọgwụ ahụ na-esi n'ime ahụ pụta, na ntọhapụ na-adabere na ọkpụrụkpụ na njupụta nke gel Layer.
Mmetụta: HPMC dị ka onye ntọhapụ na-achịkwa nwere ike ime ka ọnụego ntọhapụ ọgwụ kwụsịlata, belata ngbanwe nke itinye uche ọgwụ ọbara, ma nye mmetụta ọgwụgwọ kwụsiri ike karị, karịsịa maka ọgwụ maka ọgwụgwọ ọrịa na-adịghị ala ala.
3. Ihe nkedo
N'ime usoro nkwadebe mbadamba nkume, a na-ejikarị HPMC eme ihe dị ka ihe nkpuchi iji kwalite ike arụ ọrụ nke mbadamba nkume ma hụ na iguzosi ike n'ezi ihe nke mbadamba nkume n'oge nchekwa, njem na nchịkwa.
Usoro nke ime ihe: HPMC, dị ka ihe nkedo, nwere ike ịmepụta njikọ siri ike n'etiti ụmụ irighiri ihe, nke mere na ntụ ntụ ma ọ bụ ihe dị iche iche na-ejikọta ma guzobe n'ime mbadamba nkume siri ike. Usoro a na-emekarị site na mmiri granulation technology, ebe HPMC dissolves na aqueous ngwọta na-etolite a viscous ngwọta, na-etolite a anụ mbadamba nkume mgbe ihicha.
Mmetụta: HPMC binders nwere ike imeziwanye ike mkpakọ na ike nke mbadamba nkume, belata ihe ize ndụ nke nkwụsịtụ ma ọ bụ nkewa, wee si otú ahụ melite ogo na nkwụsi ike nke mbadamba.
4. Ọkpụkpụ
HPMC nwekwara ike-eji dị ka a thickener na mmiri mmiri preparations ịgbanwe rheological Njirimara nke preparations na-abawanye viscosity.
Usoro nke ime ihe: HPMC nwere nnukwu viscosity na mmiri ma nwee ike ịbawanye viscosity nke mmiri mmiri n'ụzọ dị irè, melite nkwusioru na nkwụsi ike nke ọgwụ, ma gbochie sedimentation.
Mmetụta: Ịtinye HPMC na ọgwụ mmiri mmiri nwere ike melite ịdị n'otu nke ọgwụ ahụ, mee ka ihe mejupụtara ọgwụ ahụ kesaa nke ọma n'oge nkwadebe, ma hụ na usoro ọgwụgwọ na-agbanwe agbanwe oge ọ bụla.
Njirimara Hydroxypropyl Methylcellulose
1. Njirimara anụ ahụ na nke kemịkalụ
HPMC bụ nonionic cellulose ether nwere ezigbo mmiri solubility na thermal gelation. Ọ na-agbaze ngwa ngwa na mmiri oyi iji mepụta ngwọta nke ọma, mgbe ọ na-ekpo ọkụ, ngwọta ahụ na-aghọ gel.
2. Biocompatibility
HPMC nwere ezigbo biocompatibility na nchekwa, na ọ naghị adị mfe ibute nzaghachi mgbochi ma ọ bụ mmetụta nsi, yabụ a na-eji ya na mpaghara ọgwụ na nri.
3. Nkwụsi ike gburugburu ebe obibi
HPMC nwere ezigbo nkwụsi ike na ihe ndị dị na gburugburu ebe obibi dị ka okpomọkụ na uru pH, ọ dịghịkwa enwe ike imebi ma ọ bụ denaturation, nke na-eme ka nkwụsi ike nke nkwadebe ọgwụ n'oge nchekwa.
Ọmụmaatụ nke ngwa HPMC na mbadamba
1. Mbadamba ụrọ ntọhapụ a na-achịkwa
Dịka ọmụmaatụ, na mbadamba nifedipine na-adịgide adịgide a na-eji agwọ ọbara mgbali elu, a na-eji HPMC dị ka ihe matriks iji chịkwaa ntọhapụ nke ọgwụ ahụ ngwa ngwa, belata oge nchịkwa, ma melite nnabata onye ọrịa.
2. Mbadamba ụrọ ndị nwere mkpuchi
N'ime mbadamba ihe mkpuchi nke proton pump inhibitors (dị ka omeprazole), HPMC na-arụ ọrụ dị ka onye na-emepụta fim iji chebe ọgwụ ahụ ka ọ ghara ibibi acid gastric ma hụ na ewepụtara ọgwụ ahụ nke ọma n'ime eriri afọ.
3. Mbadamba ụrọ na-agbari ngwa ngwa
Na mbadamba ụrọ na-agbaze ngwa ngwa maka ọgwụgwọ nke rhinitis nfụkasị ahụ, HPMC na-eme dị ka onye na-agba ume na nrapado iji nye mgbasa ngwa ngwa na ntọhapụ edo, na-eme ka uto na-enweta ahụmahụ nke ọgwụ ahụ.
A na-eji Hydroxypropyl methylcellulose mee ihe n'ọtụtụ ebe na nkwadebe nke mbadamba nkume dị iche iche n'ihi imepụta ihe nkiri dị mma, ntọhapụ a na-achịkwa, nrapado na ihe na-eme ka ọ dị elu. HPMC nwere ike ọ bụghị naanị melite anụ ahụ Njirimara na nkwụsi ike nke mbadamba, ma na-ebuli ọgwụgwọ mmetụta nke ọgwụ ọjọọ eme ihe site n'ịgbanwe ntọhapụ ọnụego nke ọgwụ. Site na mmepe nke nkà na ụzụ ọgwụ, ngwa nke HPMC ga-adịwanye iche, na-enye ohere maka ịmepụta ihe ọhụrụ nke nkwadebe ọgwụ.
Oge nzipu: Jun-27-2024