Methyl cellulose (MC) na hydroxypropyl methyl cellulose (HPMC) bụ abụọ cellulose mmepụta nke ọtụtụ-eji na ụlọ ọrụ, ewu, pharmaceuticals, nri na ndị ọzọ ubi. Ọ bụ ezie na ha yiri na nhazi, ha nwere ihe dị iche iche na E nwere nnukwu ọdịiche dị na ngwa na mmepụta usoro.
1. Ọdịiche dị na nhazi kemịkalụ
Methylcellulose (MC) na hydroxypropylmethylcellulose (HPMC) bụ ha abụọ sitere na cellulose eke ma bụrụ nke ether cellulose gbanwetụrụ na kemịkal. Mana ọdịiche ha kacha dabere n'ụdị na ọnụ ọgụgụ nke ndị nnọchi anya.
Methyl cellulose (MC)
A na-emepụta MC site na iji otu methyl dochie otu hydroxyl na cellulose (ie -OCH₃). Usoro kemịkalụ nke MC bụ nke mejupụtara methyl substituent iche iche na cellulose isi yinye, na ngbanwe ya ọnụego na-emetụta ya solubility na Njirimara. MC na-agbazekarị na mmiri oyi mana ọ bụghị na mmiri ọkụ.
Hydroxypropyl methylcellulose (HPMC)
A na-emeziwanye HPMC na ndabere nke methylcellulose, site na iji methyl (-CH₃) na hydroxypropyl (-CH₂CH (OH) CH₃ dochie akụkụ nke hydroxyl. E jiri ya tụnyere MC, usoro ihe omimi nke HPMC dị mgbagwoju anya, hydrophilicity na hydrophobicity ya na-edozi nke ọma, ọ pụkwara ịsacha ya na mmiri oyi na mmiri ọkụ.
2. Ọdịiche nke anụ ahụ na kemịkal solubility
MC: Methylcellulose n'ozuzu nwere ezigbo solubility na mmiri oyi, mana ọ ga-etolite gel mgbe okpomọkụ na-ebili. N'ime mmiri ọkụ, MC na-aghọ ihe na-adịghị ike, na-eme gel gel.
HPMC: Hydroxypropyl methylcellulose nwere ike agbaze n'otu n'otu n'otu n'otu na mmiri oyi na mmiri ọkụ, nwere oke ikuku mgbasa, yana solubility ya kwụsiri ike karịa MC.
Thermal gelability
MC: MC nwere ikike gelling thermal siri ike. Mgbe okpomọkụ na-ebili n'ọkwa ụfọdụ, ọ ga-etolite gel ma hapụ ya solubility. Njirimara a na-eme ka ọ nwee ihe pụrụ iche na-ewu na ụlọ ọrụ ọgwụ.
HPMC: HPMC nwekwara ụfọdụ thermal gelling Njirimara, ma gel guzobe okpomọkụ dị elu na gel guzobe ọsọ na-eji nwayọọ nwayọọ. E jiri ya tụnyere MC, HPMC's thermal gel properties bụ ihe a na-ejikwa ya, ya mere ọ bara uru karịa na ngwa chọrọ nkwụsi ike okpomọkụ dị elu.
Ọrụ elu
MC: MC nwere obere ọrụ elu. Ọ bụ ezie na enwere ike iji ya dị ka ihe emulsifier ma ọ bụ thickener na ngwa ụfọdụ, mmetụta adịghị mkpa dị ka HPMC.
HPMC: HPMC nwere ọrụ elu siri ike karị, ọkachasị iwebata otu hydroxypropyl, nke na-eme ka ọ dị mfe emulsify, kwụsịtụ na ịgbatị na ngwọta. Ya mere, a na-ejikarị ya eme ihe dị ka ihe mgbakwunye na mkpuchi na ihe ụlọ.
Nkwenye nnu na nkwụsi ike pH
MC: Methylcellulose enweghị nnabata nnu na-adịghị mma ma na-enwekarị oke mmiri ozuzo na gburugburu nnukwu nnu. Ọ nwere nkwụsi ike na-adịghị mma na gburugburu acid na alkali yana uru pH na-emetụta ngwa ngwa.
HPMC: N'ihi ọnụnọ nke hydroxypropyl substituent, HPMC si nnu ndidi dị nnọọ mma karịa MC, na ọ nwere ike ịnọgide na-enwe ezi solubility na nkwụsi ike na a obosara pH nso, n'ihi ya, ọ na-adabara dị iche iche chemical gburugburu.
3. Ihe dị iche na usoro mmepụta
Mmepụta nke MC
A na-emepụta Methylcellulose site na mmeghachi omume methylation nke cellulose, na-ejikarị methyl chloride mee ihe na alkaline cellulose iji dochie ìgwè hydroxyl na cellulose molecules. Usoro a na-achọ njikwa ọnọdụ mmeghachi omume iji hụ na ọkwa kwesịrị ekwesị nke nnọchi, nke na-emetụta solubility na ihe ndị ọzọ physicochemical nke ngwaahịa ikpeazụ.
Mmepụta nke HPMC
Mmepụta nke HPMC dabere na methylation ma na-agbakwunye mmeghachi omume hydroxypropylation. Ya bụ, mgbe mmeghachi omume methylation nke methyl chloride gasịrị, propylene oxide na-emeghachi omume na cellulose iji mepụta ihe nnọchi hydroxypropyl. Ntinye nke otu hydroxypropyl na-eme ka ike solubility na hydration nke HPMC dịkwuo mma, nke na-emekwa ka usoro mmepụta ya dịkwuo mgbagwoju anya ma dị ntakịrị elu karịa MC.
4. Ọdịiche dị na mpaghara ngwa
Owuwu ihe eji arụ ụlọ
MC: A na-ejikarị MC eme ihe n'ụlọ, karịsịa dị ka thickener, mmiri na-ejigide ihe na nrapado na akọrọ ngwa ngwa na putty ntụ ntụ. Agbanyeghị, n'ihi akụrụngwa gelling ya na-ekpo ọkụ, MC nwere ike daa na gburugburu oke okpomọkụ.
HPMC: A na-ejikarị HPMC eme ihe n'ubi ihe owuwu. N'ihi na ọ na-enwekwa nkwụsi ike dị mma na gburugburu ebe okpomọkụ dị elu, ọ dị mma maka ọnọdụ ndị na-achọ nkwụsị okpomọkụ dị elu, dị ka adhesives tile, mkpuchi mkpuchi na ala na-edozi onwe ya. .
Ogige ọgwụ na nri
MC: Methylcellulose bụ nke a na-ejikarị eme ihe dị ka ihe na-agbasa na thickener maka mbadamba nkume na nkwadebe ọgwụ. A na-ejikwa ya n'ụfọdụ nri dị ka ihe na-agbapụta na eriri.
HPMC: HPMC nwere uru karịa na mpaghara ọgwụ. N'ihi nkwụsi ike ya siri ike yana ezigbo bioocompatibility, a na-ejikarị ya eme ihe na ihe nkiri ewepụtara na akwa capsule maka ọgwụ. Na mgbakwunye, a na-ejikwa HPMC n'ọtụtụ ebe na ụlọ ọrụ nri, ọkachasị n'ichepụta capsules anaghị eri anụ.
Ngalaba mkpuchi na agba
MC: MC nwere mmetụta dị oke mma na imepụta ihe nkiri, mana nkwụsi ike ya na ikike ngbanwe viscosity na ngwọta adịghị mma ka HPMC.
HPMC: HPMC na-ọtụtụ ebe na agba na agba ụlọ ọrụ ruru ya magburu onwe ndim, emulsification na film-akpụ Njirimara, karịsịa dị ka a thickener na leveling gị n'ụlọnga na mmiri dabeere coatings, nke nwere ike budata mma ewu arụmọrụ na elu nke mkpuchi. . Mmetụta.
5. Nchekwa gburugburu ebe obibi na nchekwa
A na-emezi ma MC na HPMC site na cellulose eke ma nwee ezigbo biodegradability na ihe nchebe gburugburu ebe obibi. Ha abụọ adịghị egbu egbu na ndị na-adịghị emerụ ahụ na-eji ma na-agbaso ihe nchebe gburugburu ebe obibi chọrọ, n'ihi ya, ha dị nnọọ nchebe iji mee ihe n'ubi nri, ọgwụ na ihe ịchọ mma.
Ọ bụ ezie na methylcellulose (MC) na hydroxypropylmethylcellulose (HPMC) yiri usoro kemịkalụ, n'ihi otu dị iche iche na-anọchi anya ya, solubility ha, gelability thermal, ọrụ elu, usoro mmepụta na ngwa dị iche iche. Enwere ọdịiche doro anya na mpaghara na akụkụ ndị ọzọ. MC kwesịrị ekwesị maka ọnọdụ okpomọkụ dị ala na ihe dị mfe na-achọsi ike na njigide mmiri, ebe HPMC dị mma maka ụlọ ọrụ dị mgbagwoju anya, ọgwụ na ihe owuwu ụlọ n'ihi ịdị mma ya na nkwụsi ike nke okpomọkụ.
Oge nzipu: Ọktoba 25-2024