Hydroxypropyl methylcellulose (HPMC) bụ cellulose ether dị mkpa, nke a na-ejikarị eme ihe na-ewu, ọgwụ, nri, kemịkalụ kwa ụbọchị na ubi ndị ọzọ. HPMC bụ polymer soluble mmiri enwetara site na mgbanwe kemịkalụ nke cellulose eke, nwere ọtụtụ ọmarịcha anụ ahụ na kemịkal.
1. Njirimara anụ ahụ
Ọdịdị na morphology: HPMC na-abụkarị ọcha ma ọ bụ ntụ ntụ na-acha odo odo, enweghị isi, enweghị ụtọ, ma nwee ezigbo mmiri. Ọ nwere ike ịmepụta otu ihe nkiri ma ọ bụ gel site na usoro nhazi dị iche iche, nke na-eme ka ọ rụọ ọrụ nke ọma n'ọtụtụ ngwa.
Solubility: HPMC na-adị mfe soluble na mmiri oyi, mana mmiri ọkụ anaghị anyụ anyụ. Mgbe okpomọkụ ruru ọkwa ụfọdụ (na-abụkarị 60-90 ℃), HPMC na-efunahụ solubility na mmiri wee mepụta gel. Ngwongwo a na-enyere ya aka inye mmetụta na-ekpo ọkụ mgbe ọ na-ekpo ọkụ, ma laghachi na ọnọdụ ngwọta mmiri na-egbuke egbuke mgbe ọ jụrụ. Na mgbakwunye, HPMC na-agbaze n'akụkụ ụfọdụ na ihe mgbaze organic dị ka ethanol.
Viscosity: The viscosity nke HPMC ngwọta bụ otu n'ime ya mkpa anụ ahụ Njirimara. Viscosity na-adabere na ịdị arọ ya na ntinye nke ngwọta ya. N'ikwu okwu n'ozuzu, ka ibu molekụla buru ibu, ka viscosity nke ngwọta dị elu. HPMC nwere viscosity dịgasị iche iche ma nwee ike ịhazi ya dabere na ngwa ngwa achọrọ, nke na-eme ka a na-eji ya eme ihe na-ewu, ọgwụ, kemịkalụ kwa ụbọchị na ụlọ ọrụ ndị ọzọ.
Ngwongwo na-eme ihe nkiri: HPMC nwere ihe eji eme ihe nkiri mara mma. Ọ nwere ike na-etolite a transperent na siri ike film mgbe igbari na mmiri ma ọ bụ organic solvents. Ihe nkiri ahụ nwere ezigbo mmanụ na abụba na-eguzogide ya, ya mere a na-ejikarị ya eme ihe dị ka ihe mkpuchi na nri na ọgwụ ọgwụ. Na mgbakwunye, ihe nkiri HPMC nwekwara ezigbo nguzogide mmiri ma nwee ike ichebe ihe dị n'ime nke ọma site na mmiri.
Nkwụsi ike nke okpomọkụ: HPMC nwere ezigbo nkwụsi ike. Ọ bụ ezie na ọ na-efunahụ solubility ma na-emepụta gel na elu okpomọkụ, ọ nwere ezigbo nkwụsi ike nke okpomọkụ na ala akọrọ ma nwee ike iguzogide okpomọkụ nhazi dị elu na-enweghị ire ere. Njirimara a na-enye ya uru na nhazi okpomọkụ dị elu.
2. Chemical Njirimara
Nkwụsi ike kemịkalụ: HPMC nwere ezigbo nkwụsi ike kemịkalụ n'ime ụlọ ma kwụsie ike na acid, alkalis na nnu. Ya mere, n'ọtụtụ mmeghachi omume kemịkalụ ma ọ bụ usoro nhazi, HPMC nwere ike ịdị ka ihe nkwụsi ike na ọ dịghị mfe iji ihe ndị ọzọ meghachi omume na kemịkal.
Nkwụsi ike pH: HPMC na-anọgide na-akwụsi ike na pH 2-12, nke na-eme ka ọ bụrụ nke a na-eji mee ihe na gburugburu pH dị iche iche. HPMC agaghị enweta hydrolysis ma ọ bụ mmebi n'okpuru ọnọdụ acidic ma ọ bụ alkaline, nke na-eme ka a na-ejikarị ya na nri, ọgwụ na ihe ịchọ mma.
Biocompatibility na enweghị nsi: HPMC nwere ezigbo bioacompatibility na enwere ike iji ya na ọgwụ, nri na mpaghara ndị ọzọ nwere oke ihe achọrọ maka ahụike mmadụ. HPMC bụ onye na-adịghị egbu egbu na nke na-adịghị ewe iwe, na agaghị agbajikwa n'ime obere ụmụ irighiri site digestive enzymes n'ime ahụ, n'ihi ya, ọ ga-eji dị ka a na-achịkwa ntọhapụ n'ụlọnga maka ọgwụ ọjọọ ma ọ bụ thickener nri.
Mgbanwe kemịkalụ: HPMC nwere ọnụ ọgụgụ dị ukwuu nke hydroxyl dị iche iche n'ụdị molekụla ya, nke enwere ike imeziwanye ma ọ bụ nye akụrụngwa ọhụrụ site na ngbanwe kemịkalụ ọzọ. Dịka ọmụmaatụ, site na imeghachi omume na aldehydes ma ọ bụ organic acid, HPMC nwere ike ịkwadebe ngwaahịa nwere oke okpomọkụ na-eguzogide ma ọ bụ mmiri na-eguzogide. Na mgbakwunye, HPMC nwekwara ike ịgwakọta ya na polymers ndị ọzọ ma ọ bụ ihe mgbakwunye iji mepụta ihe mejupụtara iji gboo mkpa nke ngwa ngwa.
Mgbasa mmiri mmiri: HPMC nwere hygroscopicity siri ike ma nwee ike ịmịkọrọ mmiri sitere na ikuku. Ngwongwo a na-enye HPMC ohere ito oke ma mezie iru mmiri nke ngwaahịa na ngwa ụfọdụ. Agbanyeghị, n'ọnọdụ ụfọdụ, nnabata oke mmiri nwere ike imetụta nkwụsi ike nke ngwaahịa ahụ, yabụ, ọ dị mkpa ka echebara mmetụta nke iru mmiri ihu na arụmọrụ nke HPMC mgbe ị na-eji ya.
3. Ngwa ngwa na uru
N'ihi njirimara anụ ahụ na kemịkal pụrụ iche, HPMC nwere uru ngwa dị ukwuu n'ọtụtụ mpaghara. Dịka ọmụmaatụ, n'ebe a na-ewu ihe owuwu, a na-eji HPMC eme ihe dị ka ihe na-ekpuchi mmiri na mmiri na-eji ciment eme ihe iji meziwanye ihe owuwu na ịdịte aka nke ihe ụlọ; n'ọhịa ọgwụ, a na-ejikarị HPMC eme ihe dị ka nrapado mbadamba, ihe ntọhapụ a na-achịkwa, na ihe mkpuchi capsule; n'ubi nri, a na-eji ya dị ka ihe na-agba agba, emulsifier, na stabilizer iji meziwanye uto na udidi nke nri.
Hydroxypropyl methylcellulose na-arụ ọrụ na-enweghị atụ n'ọtụtụ ụlọ ọrụ n'ihi ọmarịcha anụ ahụ na kemịkal ya. Ya pụtara ìhè arụmọrụ na mmiri solubility, film-akpụ Njirimara, chemical kwụsie ike, wdg na-eme HPMC ihe dị oké mkpa multifunctional ihe na ụlọ ọrụ na kwa ụbọchị ndụ.
Oge nzipu: Ọgọst-22-2024