Hydroxypropyl methylcellulose (HPMC, Hydroxypropyl Methylcellulose) bụ ihe dị mkpa cellulose ether, nke a na-ejikarị eme ihe n'iwu ụlọ, ọgwụ, nri na ubi ndị ọzọ, ma bụrụ nke a na-ahụkarị na ihe owuwu ụlọ. Njide mmiri nke HPMC bụ otu n'ime ihe ndị dị mkpa ma na-arụ ọrụ dị mkpa na arụmọrụ nke ọtụtụ ọnọdụ ngwa. Ihe ndị na-emetụta njide mmiri nke HPMC gụnyere usoro ihe omimi, ogo nke nnọchi, ịdị arọ molecular, solubility, okpomọkụ gburugburu, ihe mgbakwunye, wdg.
1. Ọdịdị molekụla
HPMC bụ ihe nrụpụta cellulose nke usoro ihe omimi ya nwere mmetụta dị ukwuu na njide mmiri. Usoro ihe omimi nke HPMC nwere hydrophilic hydroxyl (-OH), lipophilic methyl (-CH₃) na hydroxypropyl (-CH₂CHOHCH₃). Oke na nkesa nke otu hydrophilic na lipophilic nwere mmetụta kpọmkwem na arụmọrụ njigide mmiri nke HPMC.
Ọrụ nke otu hydroxyl: Otu Hydroxyl bụ otu hydrophilic nwere ike ịmepụta njikọ hydrogen na ụmụ irighiri mmiri, si otú a na-enyere aka melite njide mmiri nke HPMC.
Ọrụ nke methyl na hydroxypropyl dị iche iche: Ndị otu a bụ hydrophobic ma nwee ike imetụta solubility na gelation okpomọkụ nke HPMC na mmiri, si otú ahụ na-emetụta ọrụ njigide mmiri.
2. Degree nke nnọchi
Ogo nke nnọchi (DS) na-ezo aka na nkezi ọnụọgụ nke otu hydroxyl nọchiri anya n'ime mkpụrụ ndụ cellulose. Maka HPMC, ogo nnọchi nke methoxy (-OCH₃) na hydroxypropoxy (-OCH₂CHOHCH₃) na-enwekarị nchegbu, ya bụ, ogo nnọchi nke methoxy (MS) na ogo nnọchi nke hydroxypropoxy (HP):
Ọkwa dị elu nke nnọchi: Ka ogo nnọchi anya dị elu, ka otu HPMC na-enwekwu hydrophilic, na usoro iwu ga-emeziwanye njide mmiri. Otú ọ dị, ogo dị elu nke ngbanwe nwere ike iduga oke solubility, na mmetụta njide mmiri nwere ike ibelata.
Ọkwa dị ala nke nnọchi: HPMC nwere ogo dị ala nke nnọchi nwere adịghị ike solubility na mmiri, mana usoro netwọk e hibere nwere ike kwụsie ike karị, si otú a na-ejigide njide mmiri ka mma.
Ịmezi ogo ngbanwe n'ime ebe ụfọdụ nwere ike ịkwalite njide mmiri nke HPMC. Ogo ngbanwe a na-ahụkarị na-abụkarị 19-30% maka methoxy yana 4-12% maka hydroxypropoxy.
3. Ibu ibu
Ibu molekụla nke HPMC nwere mmetụta dị ukwuu na njide mmiri ya:
Ibu molekụla dị elu: HPMC nwere oke molekul nwere ogologo agbụ molekụla wee mepụta usoro netwọkụ denser, nke nwere ike ịnabata ma na-ejigide mmiri, si otú a na-eme ka njide mmiri dịkwuo mma.
Ibu molekụla dị ala: HPMC nwere obere molekul nwere obere mkpirisi na ikike njigide mmiri na-adịghị ike, mana ọ nwere ezigbo solubility yana dabara maka ngwa chọrọ mgbasa ngwa ngwa.
Dịka, ụdị arọ molekụla nke HPMC eji eme ihe eji arụ ụlọ sitere na 80,000 ruo 200,000.
4. Solubility
Solubility nke HPMC na-emetụta njide mmiri ya ozugbo. Ezi solubility na-enyere HPMC aka ịgbasa n'ụzọ zuru ezu na matriks, si otú a na-akpụ a edo edo-edochi ihe owuwu. Solubility na-emetụta site na:
Okpomọkụ mgbasa: HPMC na-agbaze nwayọọ nwayọọ na mmiri oyi, mana ọ na-agbaze ngwa ngwa na mmiri ọkụ. Otú ọ dị, oke okpomọkụ ga-eme ka HPMC gbazee nke ukwuu, na-emetụta nhazi mmiri ya.
Uru pH: HPMC na-enwe mmetụta maka uru pH ma nwee ike solubility ka mma na gburugburu acidic na-anọpụ iche ma ọ bụ adịghị ike. Ọ nwere ike mebie ma ọ bụ belata solubility n'okpuru oke pH ụkpụrụ.
5. Ambient okpomọkụ
Okpomọkụ nwere mmetụta dị ukwuu na njide mmiri nke HPMC:
Okpomọkụ dị ala: Na obere okpomọkụ, solubility nke HPMC na-ebelata, ma viscosity dị elu, nke nwere ike ịmepụta usoro na-ejigide mmiri kwụsie ike.
Okpomọkụ dị elu: Okpomọkụ dị elu na-eme ka mgbasa nke HPMC gbasaa ngwa ngwa, mana ọ nwere ike imebi ihe nhazi nke mmiri na-emetụta mmetụta ya na-ejigide mmiri. N'ozuzu, ezigbo njigide mmiri nwere ike ịnọgide na-enwe n'okpuru 40 ℃.
6. Ihe mgbakwunye
A na-ejikarị HPMC na mgbakwunye ndị ọzọ eme ihe na ngwa bara uru. Ihe mgbakwunye ndị a nwere ike imetụta njigide mmiri nke HPMC:
Plasticizers: dị ka glycerol na ethylene glycol, nke nwere ike melite mgbanwe na mmiri njide nke HPMC.
Fillers: dị ka gypsum na quartz ntụ ntụ, ga-emetụta njide mmiri nke HPMC ma gbanwee àgwà mgbasa ya na mgbasa ya site na ịmekọrịta na HPMC.
7. Ọnọdụ ngwa
A ga-emetụtakwa arụmọrụ njigide mmiri nke HPMC n'okpuru ọnọdụ ngwa dị iche iche:
Ọnọdụ ihe owuwu: dị ka oge ihe owuwu, iru mmiri gburugburu, wdg ga-emetụta mmetụta njide mmiri nke HPMC.
Ọnụ ego ojiji: Ọnụ ego HPMC na-emetụta njide mmiri ozugbo. N'ozuzu, HPMC nwere oke onunu ogwu na-egosi mmetụta njide mmiri ka mma na ngwa ngwa ciment na ihe ndị ọzọ.
Enwere ọtụtụ ihe na-emetụta njide mmiri nke HPMC, gụnyere usoro ihe omimi ya, ogo nke nnọchi, ịdị arọ molecular, solubility, okpomọkụ gburugburu, ihe mgbakwunye, na ọnọdụ ngwa n'ezie. N'oge usoro ngwa ahụ, site n'iji ezi uche na-ahọrọ ma na-edozi ihe ndị a, a na-eme ka ọrụ njigide mmiri nke HPMC dịkwuo mma iji gboo mkpa nke ubi dị iche iche.
Oge nzipu: Jun-24-2024