Hydroxypropyl Methylcellulose (HPMC) bụ ihe nrụpụta cellulose dị mkpa nwere ọtụtụ ngwa n'ọtụtụ ụlọ ọrụ. Ọ nwere ezigbo anụ ahụ na kemịkalụ, obere nsi, na enyi gburugburu ebe obibi.
1. Ihe ndị bụ isi nke HPMC
Usoro kemịkalụ na ihe anụ ahụ
HPMC bụ cellulose ether na-abụghị ionic enwetara site na mgbanwe kemịkalụ nke cellulose eke. Nhazi ya bụ nkeji glucose, nke a na-etolite site na iji hydroxypropyl na methyl dochie ụfọdụ otu hydroxyl. Ụdị anụ ahụ ya na-akachasị ọcha ma ọ bụ ntụ ntụ na-acha odo odo, nke na-adị mfe soluble na mmiri oyi na mmiri ọkụ iji mepụta ngwọta na-enweghị ntụpọ ma ọ bụ ntakịrị turbid viscous.
Arọ molecular: HPMC nwere ọtụtụ ihe dị iche iche nke mkpụrụ ndụ ihe nketa, site na ịdị arọ dị ala (dị ka 10,000 Da) ruo n'ịdị arọ molekụla dị elu (dị ka 150,000 Da), na ihe onwunwe ya na ngwa ya na-agbanwekwa ya.
Solubility: HPMC na-etolite ihe ngwọta colloidal na mmiri oyi, mana ọ bụ ihe a na-adịghị ahụkebe na ụfọdụ ihe mgbaze organic, ma nwee ezigbo solubility na nkwụsi ike.
Viscosity: Viscosity bụ ihe dị mkpa nke HPMC, nke na-emetụta ịdị arọ molekụla na ụdị na ọnụ ọgụgụ nke ndị nọchiri anya ya. A na-ejikarị HPMC nwere viscosity dị elu dị ka onye na-agba ume na stabilizer, ebe HPMC na-enweghị viscosity na-eji maka ịme ihe nkiri na ọrụ njikọ.
Nkwụsi ike nke kemịkal
HPMC nwere nnukwu kemịkalụ nkwụsi ike, nwere ike iguzogide mbuze nke acid, alkalis na ihe mgbaze nkịtị, ọ dịghịkwa mfe ire ere ma ọ bụ mebie ya. Nke a na-enye ya ohere ịnọgide na-arụ ọrụ ya na gburugburu ebe dị mgbagwoju anya ma dị mma maka ọtụtụ ngwa ọrụ mmepụta ihe.
Biocompatibility
Ebe ọ bụ na HPMC sitere na cellulose eke na emezigharị ya nke ọma, ọ nwere ezigbo bioacompatibility na obere nsi. Ya mere, a na-ejikarị ya na nri, ọgwụ na ihe ịchọ mma, na-ezute ihe nchekwa chọrọ.
2. Usoro nkwadebe nke HPMC
A na-ekekarị nkwadebe nke HPMC ụzọ atọ:
Ọgwụgwọ Alkali: A na-agwọ cellulose eke na ngwọta alkali (na-abụkarị sodium hydroxide) iji zaa ya ma mee ka mmeghachi omume ya dịkwuo elu.
Mmeghachi omume etherification: N'okpuru ọnọdụ alkaline, cellulose na-enweta mmeghachi omume etherification na methyl chloride na propylene oxide, na-ewebata methyl na hydroxypropyl otu iji mepụta hydroxypropyl methylcellulose.
Ọcha: A na-ewepụ ihe ndị sitere na mmeghachi omume na residual reagents site na ịsacha, nzacha na ihicha iji nweta HPMC dị ọcha.
Site n'ịchịkwa mmeghachi omume ọnọdụ (dị ka okpomọkụ, oge, reagent ruru, wdg), ogo nke nnọchi na molekụla arọ nke HPMC nwere ike gbanwee iji nweta ngwaahịa dị iche iche Njirimara.
3. Ngwa ubi nke HPMC
Ihe owuwu ụlọ
N'ime ụlọ ọrụ ihe owuwu, a na-eji HPMC eme ihe na ngwa ngwa ciment, ngwaahịa gypsum, mkpuchi, wdg. Ọrụ ya gụnyere:
Ịba ụba na njide mmiri: Na ngwa agha na mkpuchi, HPMC nwere ike ịbawanye viscosity ma melite arụmọrụ ihe owuwu, ebe ọ na-enye mmetụta dị mma na-ejigide mmiri ma na-egbochi nkwụsịtụ shrinkage.
Imelite nrapado: Na-eme ka adhesion dị n'etiti ngwa agha na mkpụrụ osisi na-eme ka mma ụlọ dị mma.
Imeziwanye ihe owuwu ihe: Ime ka owuwu nke ngwa ngwa na mkpuchi dị mfe, ịgbatị oge na-emeghe ma na-emeziwanye ịdị nro n'elu.
Ụlọ ọrụ ọgwụ
Ngwa nke HPMC na ụlọ ọrụ ọgwụ na-egosipụtakarị na nkwadebe ọgwụ, ọkachasị mbadamba ọnụ na capsules:
Ihe ntọhapụ a na-achịkwa: A na-ejikarị HPMC akwadebe mbadamba ihe ntọhapụ a na-achịkwa, a na-enwetakwa ntọhapụ nke ọgwụ ngwa ngwa site n'ịgbanwe ọnụego mgbasa.
Mbadamba ụrọ: Na mmepụta mbadamba, HPMC nwere ike iji dị ka ihe nkedo iji nye mbadamba nkume siri ike na oge nkwụsịtụ kwesịrị ekwesị.
Ihe mkpuchi ihe nkiri: ejiri ya dị ka ihe mkpuchi maka mbadamba nkume iji gbochie oxidation na mmiri mmiri nke ọgwụ ọjọọ ma melite nkwụsi ike na ọdịdị ọgwụ.
Ụlọ ọrụ nri
A na-eji HPMC dị ka ihe mgbakwunye nri na ụlọ ọrụ nri, na-arụ ọrụ nke thickener, emulsifier, stabilizer, wdg.:
Thickerer: eji na mmiri ara ehi ngwaahịa, sauces, wdg iji nye ezigbo udidi na uto.
Emulsifier: na ihe ọṅụṅụ na ice cream, ọ na-enyere aka ịmepụta usoro emulsified kwụsiri ike.
Ihe nkiri mbụ: na swiiti na achịcha, a na-eji HPMC maka mkpuchi na ihe na-egbuke egbuke iji meziwanye ọdịdị na ọdịdị nke nri.
Ihe ịchọ mma
Na ihe ịchọ mma, a na-eji HPMC akwadebe emulsions, creams, gels, wdg.:
Ịba ụba na nkwụsi ike: na ihe ịchọ mma, HPMC na-enye viscosity na nkwụsi ike kwesịrị ekwesị, na-eme ka ederede na mgbasawanye.
Ịgba mmiri: nwere ike ịmepụta oyi akwa n'elu akpụkpọ ahụ iji mee ka mmetụta dị nro nke ngwaahịa ahụ dịkwuo elu.
Kemikal kwa ụbọchị
A na-ejikwa HPMC na ngwaahịa kemịkalụ kwa ụbọchị, dị ka ncha, ngwaahịa nlekọta onwe onye, wdg.
Thickener: na ncha, ọ na-abawanye viscosity nke ngwaahịa iji gbochie stratification.
Onye nnọchi anya nkwusioru: ejiri ya na sistemụ nkwusioru iji nye nkwụsi ike nkwusioru dị mma.
4. Uru na ihe ịma aka nke HPMC
Uru
Ntughari: HPMC nwere ọtụtụ ọrụ ma nwee ike rụọ ọrụ dị iche iche na mpaghara dị iche iche, dị ka ịgbatị, njide mmiri, nkwụsi ike, wdg.
Biocompatibility: Obere toxicity na ezigbo biocompatibility na-eme ka ọ dabara adaba maka iji nri na ọgwụ.
Enyi na gburugburu ebe obibi: ewepụtara site na cellulose eke, biodegradable na enyi na gburugburu ebe obibi.
Ihe ịma aka
Ọnụ: Tụnyere ụfọdụ ihe polymer sịntetik, HPMC nwere ọnụ ahịa dị elu, nke nwere ike belata ojiji ya zuru ebe niile na ngwa ụfọdụ.
Usoro mmepụta: Usoro nkwadebe na-agụnye mmeghachi omume kemịkalụ dị mgbagwoju anya na usoro nchacha, nke kwesịrị ịchịkwa nke ọma iji hụ na ngwaahịa dị mma.
5. Atụmanya n'ọdịnihu
Site na ọganihu nke sayensị na teknụzụ, atụmanya ngwa nke HPMC dị nnọọ ukwuu. Ntuziaka nyocha n'ọdịnihu nwere ike ịgụnye:
Mmepe nke HPMC emezigharịrị: Site na mgbanwe kemịkalụ na teknụzụ mejupụtara, a na-emepụta ihe nrụpụta HPMC nwere ọrụ akọwapụtara iji mezuo ihe achọrọ.
Usoro nkwadebe akwụkwọ ndụ akwụkwọ ndụ: Nyochaa usoro nkwado gburugburu ebe obibi na nke ọma iji belata ọnụ ahịa mmepụta na ibu gburugburu.
Mpaghara ngwa ọhụrụ: Nyochaa ngwa nke HPMC n'ọhịa na-apụta, dị ka biomaterials, nkwakọ ngwaahịa na-emebi emebi, wdg.
Dị ka ihe dị mkpa cellulose mmepụta, hydroxypropyl methylcellulose (HPMC) nwere magburu onwe anụ ahụ na kemịkal Njirimara, iche iche ngwa ngwa na ezi biocompatibility. N'ọdịnihu mmepe, site na nkà na ụzụ ọhụrụ na mgbasawanye ngwa, HPMC na-atụ anya na-egwu ya pụrụ iche uru na ọtụtụ ubi na-enye ọhụrụ mkpali maka ulo oru mmepe.
Oge nzipu: Jun-25-2024