(1). Okwu mmalite
Hydroxypropyl methylcellulose (HPMC), nke a makwaara dị ka hydroxypropyl methylcellulose, bụ cellulose ether nke ọkara synthetic nwere ọtụtụ ngwa ọgwụ. Ngwa nke HPMC na mpaghara ọgwụ bụ tumadi n'ihi ọmarịcha anụ ahụ na kemịkal ya, gụnyere imepụta ihe nkiri, gelling, ndim, nrapanye na nkwụsi ike. Dị ka ihe inert na nke na-abụghị ionic compound, HPMC nwere ike n'ụzọ dị irè na-enye njikwa ntọhapụ, uto masking, film-akpụ, adhesion na nchebe ọrụ na ọgwụ nkwadebe.
(2). Ihe mejupụtara na nkwadebe
A na-emezi HPMC site na methylation akụkụ na hydroxypropylation nke cellulose site na etherification nke cellulose na methanol na propylene oxide n'okpuru ọnọdụ alkaline. Njirimara nke HPMC, dị ka viscosity, gelation okpomọkụ na solubility, na-emetụta ọdịnaya ya nọchiri anya ya na ịdị arọ molekụla. Mmepụta nke ọkwa ọgwụ HPMC ga-enwerịrị ụkpụrụ dị mma iji hụ na ịdị ọcha ya na ịdịgidesi ike iru ihe achọrọ maka nkwadebe ọgwụ.
(3). Njirimara anụ ahụ na kemịkal
Ihe na-emepụta ihe nkiri: HPMC nwere ike ịmepụta ihe nkiri na-enweghị atụ, enweghị agba, na-agbanwe agbanwe.
Mmiri solubility: Ọ na-agbaze ngwa ngwa na mmiri oyi, ma na-emepụta gel na mmiri ọkụ.
Njikwa viscosity: Enwere ike ịchịkwa viscosity nke ngwọta HPMC site n'ịgbanwe nhazi ya na ịdị arọ molecular.
Inertness kemịkalụ: Ọ kwụsiri ike na kemịkalụ n'ọtụtụ ọnọdụ yana ọ naghị emeghachi omume na ihe ọgwụ.
(4). Ngwa ọgwụ
4.1 Nkwadebe ntọhapụ a na-achịkwa
HPMC na-arụ ọrụ dị mkpa na nkwado ntọhapụ na-achịkwa-achịkwa. Ọ nwere ike ịmepụta ihe mgbochi gel, na-achịkwa ọnụego mgbasa nke ọgwụ ahụ, wee nweta nzube nke ịgbatị oge ọgwụ ahụ.
Mbadamba ụgbụ a na-achịkwa ọnụ: Site na ịgwakọta ọgwụ ahụ, ọ na-etolite matriks maka mwepụta ọgwụ ahụ nwayọ. Dị ka ihe bụ isi ihe dị n'ụfọdụ mbadamba ụgbụ a na-ahapụ, HPMC nwere ike jiri nwayọọ nwayọọ mee ka mmiri dị ọcha wee mepụta akwa gel iji chịkwaa ntọhapụ nke ọgwụ ahụ.
Microspheres na microcapsules: Dị ka onye na-emepụta ihe nkiri ma ọ bụ ihe nkwusioru stabilizer, a na-eji ya na-ekpuchi akụkụ ọgwụ ma belata ọnụego ntọhapụ.
4.2 Ihe mkpuchi
Dị ka ihe mkpuchi, HPMC nwere ike inye nchebe ọgwụ, ntọhapụ njikwa, melite ọdịdị, ma kpuchie isi ma ọ bụ ụtọ na-adịghị mma.
Ihe mkpuchi ihe: HPMC na-ejikọta ya na polymers ndị ọzọ na-eme ka ihe mkpuchi nke na-eguzogide ọgwụ na-eguzogide ọgwụ gastric, na-eme ka a na-ahapụ ọgwụ ahụ n'ime eriri afọ karịa n'ime afọ.
Ihe mkpuchi ihe nkiri: Ihe mkpuchi ihe nkiri na-eji mbadamba nkume ma ọ bụ granules iji meziwanye nkwụsi ike na ilo nkasi obi.
4.3 Njikọ
Njirimara njide nke HPMC na-eme ka ọ bụrụ ihe ejikọtara nke ọma maka nkwadebe mbadamba. Ọ nwere ike melite compressibility nke powders na n'ibu ike nke mbadamba.
Mbadamba ụrọ: A na-eji ya dị ka ihe nkedo na mmiri granulation iji hụ na enwere ike ịgbanye ntụ ntụ n'ime mbadamba nkume siri ike na nke edo.
Nkwadebe granular: HPMC nwere ike melite ịdị n'otu na ike nke granules ma belata oge nkwụsị.
4.4 Thickers na ndị na-akwụsịtụ
Dị ka thickeners na suspending elekọta mmadụ, HPMC nwere ike melite nkwụsi ike na edo edo nke mmiri mmiri preparations.
Mmiri mmiri ọnụ: kwalite uto na nkwụsi ike ma gbochie mmiri ozuzo nke ihe.
Ngwa isiokwu: A na-eji ya dị ka ihe na-agba agba na ude na gels iji nye viscosity na aka kwesịrị ekwesị.
4.5 Ngwa anya
A na-eji HPMC eme ihe n'ọtụtụ ebe na nkwadebe anya, karịsịa anya mmiri artificial na gels ophthalmic.
Anya mmiri artificial: Dị ka mmanu mmanu, ọ na-enye mmetụta dị nro na-edozi ahụ ma na-ebelata mgbaàmà anya nkụ.
Gel ophthalmic: Na-agbatị oge obibi nke ọgwụ n'elu anya ma na-eme ka ọ dị mma.
4.6 Capsules
Enwere ike iji HPMC mepụta capsules onye anaghị eri anụ (capsules HPMC) dịka nnọchi maka capsules gelatin, dabara maka ndị anaghị eri anụ ma ọ bụ ndị ọrịa nwere ihe nfụkasị maka ihe ndị sitere na anụmanụ.
Capsules onye anaghị eri anụ: Na-enye ihe mgbaze yiri nke ahụ na capsules gelatin na nsogbu ụkpụrụ omume nke ihe ndị sitere na anụmanụ anaghị emetụta ya.
(5). Uru
Biocompatibility: HPMC anaghị egbu egbu na enweghị mgbakasị ahụ, dabara maka nkwadebe ọgwụ dị iche iche.
Nkwụsi ike nke kemịkalụ: anaghị emeghachi omume na ihe ndị na-emepụta ọgwụ na-arụ ọrụ ma na-ejigide ọrụ ọgwụ.
Ntughari: Enwere ike iji ya na ntọhapụ a na-achịkwa, mkpuchi, njikọ, nkwusioru na nkwusioru.
Enyi na gburugburu ebe obibi: HPMC bụ nke sitere na cellulose eke ma bụrụ nke a na-emegharịgharị na nke nwere ike imegharị ya.
6. Ihe ịma aka na atụmanya
Agbanyeghị na HPMC nwere ọtụtụ uru na nkwadebe ọgwụ, enwerekwa ihe ịma aka n'ọnọdụ ụfọdụ. Dịka ọmụmaatụ, akụrụngwa anụ ahụ ya nwere ike ịdị mkpa ka emeziwanye ya iji hụ na ahapụpụtara otu ọgwụ na oke ọgwụ. Tụkwasị na nke ahụ, nchọpụta n'ọdịnihu nwere ike ilekwasị anya n'ịkwalite ngwa ngwa nke HPMC na usoro nnyefe ọgwụ na-arụ ọrụ dị elu site na mgbanwe mkpụrụ ndụ ma ọ bụ ijikọta ya na ihe ndị ọzọ na-eme ka ọ dịkwuo mma.
Ọkwa ọgwụ hydroxypropyl methylcellulose (HPMC) na-arụ ọrụ a na-apụghị dochie anya na usoro ọgwụ ọgbara ọhụrụ n'ihi ike ya na njirimara physicochemical dị mma. Site na ntọhapụ a na-achịkwa, mkpuchi na-ejikọta na ịgbatị, ngwa ngwa nke HPMC dị obosara ma gbasaa. Site na ọganihu nke teknụzụ na mmepe nke ọgwụ ọhụrụ, HPMC ga-arụ ọrụ dị mkpa na usoro nnyefe ọgwụ n'ọdịnihu.
Oge nzipu: Jun-14-2024