Kedu ihe bụ hypromellose phthalate?

Hypromellose phthalate (HPMCP) bụ ụdị ọgwụ excipient nke a na-eji na-emepụta ụdị onunu ogwu, karịsịa na mmepụta nke mbadamba nkume na capsules nwere mkpuchi. A na-enweta ya site na cellulose, nke bụ polymer eke nke na-emepụta akụkụ nhazi nke mgbidi cell osisi. HPMCP bụ ihe soluble mmiri, polymer anionic nke a na-ejikarị dị ka ihe mkpuchi enteric n'ihi ọmarịcha ihe na-emepụta ihe nkiri, nkwụsi ike, na iguzogide mmiri gastric.

Ebu ụzọ weba HPMCP na mmalite 1970s wee bụrụ ihe mkpuchi mkpuchi nke a na-ejikarị eme ihe n'ihi ihe pụrụ iche ya. A na-emepụta ya site na esterification nke hypromellose na phthalic acid ma dị na ọkwa dị iche iche dị iche iche, dabere na ogo phthalation na molecular arọ nke polymer. Akara ule HPMCP a na-ejikarị eme ihe bụ HPMCP-55, HPMCP-50, na HPMCP-HP-55, nke nwere ogo phthalation dị iche iche ma dabara adaba maka ojiji n'ụdị usoro dị iche iche.

Isi ọrụ nke HPMCP na usoro ọgwụ bụ ichebe ihe ndị na-arụ ọrụ nke ọgwụ ahụ site na mmebi na gburugburu acidic nke afọ. Mgbe a na-etinye mbadamba nkume ma ọ bụ capsule nke nwere HPMCP, mkpuchi ahụ na-anọgide na-adịgide adịgide n'ime afọ n'ihi obere pH, ma ozugbo ụdị usoro onunu ogwu ruru ebe alkaline karịa nke obere eriri afọ, mkpuchi ahụ na-amalite ịgbaze ma hapụ ihe ndị na-arụ ọrụ. Ntọhapụ a na-egbu oge na-enyere aka hụ na a na-ebuga ọgwụ ahụ na saịtị a na-eme ihe yana na acid gastric adịghị emebi nrụpụta ya.