Hydroxypropylmethylcellulose (HPMC) bụ polymer multifunctional nke a na-ejikarị na ọgwụ, nri, ihe ntecha, na ngwa ụlọ ọrụ dị iche iche. Ọrụ ya nwere njikọ chiri anya na njirimara viscosity ya, nke na-arụ ọrụ dị oke mkpa n'ịchọpụta arụmọrụ ya n'ụdị dị iche iche. Edemede a na-enyocha mkpa viscosity dị na ọrụ HPMC, na-ekwurịta mmetụta ya na akụrụngwa ndị dị ka ịgba, gelling, nhazi ihe nkiri, na ntọhapụ na-adịgide adịgide.
Hydroxypropylmethylcellulose (HPMC) bụ polymer synthetic ọkara nke ewepụtara na cellulose ma gbanwee site na mmeghachi omume kemịkal. Ọ nwere ọtụtụ ngwa dị iche iche n'ihi ihe ndị pụrụ iche ya, gụnyere mmiri solubility, ike ịmepụta ihe nkiri na ọdịdị na-abụghị ionic. N'ime njirimara ya dị iche iche, viscosity bụ isi ihe na-emetụta ọrụ ya na ngwa dị iche iche.
Ọrụ viscosity 1.HPMC:
1.1 Na-agba ọsọ:
Otu n'ime isi ọrụ nke HPMC na ọtụtụ usoro bụ ndim. The viscosity nke a HPMC ngwọta na-metụtara kpọmkwem ike ya dịkwuo viscosity nke gburugburu gburugburu. A na-ejikarị akara ule viscosity HPMC dị elu na ngwa ndị na-eme mkpụkọ dị ka agba, nrapado na ngwaahịa nlekọta onwe onye. Mmetụta dị nro na-esi na ike nke polymer na-ejikọta na ịmepụta netwọk n'ime ihe mgbaze, si otú ahụ na-egbochi mgbasa nke usoro.
1.2 Ịgba ọsọ:
Na mgbakwunye na ndim, HPMC nwekwara ike igosipụta njirimara gelling n'okpuru ọnọdụ ụfọdụ. Omume gelation nwere njikọ chiri anya na viscosity nke ngwọta HPMC. Ogo viscosity dị elu na-etolite gels siri ike ma nwee nkwụsi ike ka ukwuu. Gelation dị mkpa karịsịa na usoro ọgwụ, ebe a na-eji HPMC mepụta matrices na-achịkwa ma ọ bụ iji nye viscosity na gels na mmanụ mmanụ.
1.3 Nhazi ihe nkiri:
A na-eji HPMC eme ihe n'ọtụtụ ebe n'ụdị mkpuchi, ihe nkiri na mkpuchi n'ihi ike imepụta ihe nkiri ya. Viscosity nke HPMC ngwọta na-emetụta nke ukwuu usoro nhazi ihe nkiri. Maka ngwa na-achọ ihe nkiri gbara ọkpụrụkpụ nke nwere ike arụ ọrụ ka mma yana ihe mgbochi, akara viscosity dị elu na-ahọrọ. Nhazi nke ihe nkiri na-aga n'ihu na-adabere na viscosity nke ngwọta polymer na ikike ya ịgbasa ọbụna na mkpụrụ.
1.4 Ntọhapụ na-adịgide adịgide:
Na usoro ọgwụ, a na-ejikarị HPMC eme ihe dị ka matriks nke bụbu maka ụdị ntọhapụ a na-achịkwa. Ọnụego mwepụta nke ihe na-arụ ọrụ sitere na matriks na-emetụta viscosity nke ngwọta HPMC. Ogo viscosity dị elu na-ebute ọnụego ntọhapụ nke nta nke nta site na matriks n'ihi na a na-egbochi mgbasa nke mkpụrụ ndụ ọgwụ site na matriks polymer fụrụ akpụ. Nke a na-enyere aka ịmepụta ụdị ntọhapụ na-adịgide adịgide nwere profaịlụ ntọhapụ ọgwụ agbatị.
2. Ihe na-emetụta viscosity HPMC:
Ọtụtụ ihe nwere ike imetụta viscosity nke ngwọta HPMC, gụnyere:
Arọ Molecular: Akara ule HPMC dị elu na-egosipụtakarị viscosities dị elu n'ihi mmụba n'agbụ agbụ.
Ọkwa nke nnọchi: ogo nnọchi nke hydroxypropyl na methyl otu na cellulose isi yinye na-emetụta solubility na viscosity nke HPMC.
Ntụkwasị: The viscosity nke HPMC ngwọta n'ozuzu na-abawanye na-abawanye na polymer itinye uche na a na-abụghị linear mmekọrịta.
Okpomọkụ: Viscosity metụtara okpomọkụ. N'ịdị elu nke okpomọkụ, viscosity ga-ebelata n'ihi mbelata mmekọrịta n'etiti polymer na ihe mgbaze.
pH na ike ionic: Mgbanwe na pH na ike ionic nwere ike gbanwee solubility na viscosity nke HPMC site na ionization na mgbagwoju anya mmetụta.
3. Jikwa viscosity HPMC:
Ndị na-emepụta ihe nwere ike ijikwa viscosity nke ngwọta HPMC iji nweta nsonaazụ achọrọ na ngwa dị iche iche:
Nhọrọ nke akara ule HPMC: Akara ule HPMC dị iche iche dị na viscosities dị iche iche iji zute ihe ndị chọrọ nhazi.
Ịgwakọta na ndị ọzọ polymers: Ịgwakọta HPMC na ndị ọzọ polymers ma ọ bụ ihe mgbakwunye nwere ike ịgbanwe ya viscosity na welie ya ọrụ.
Gbanwee ntinye uche: Ịchịkwa ntinye nke HPMC na nhazi ahụ na-enye ohere nhazi nke ọma nke viscosity.
Njikwa okpomọkụ: Enwere ike iji njikwa okpomọkụ gbanwee viscosity nke ngwọta HPMC n'oge nhazi.
Mgbanwe pH na ike ionic: Ịgbanwe pH na ike ionic nke nhazi nwere ike imetụta solubility na viscosity nke HPMC.
Viscosity na-arụ ọrụ dị oke mkpa na igbochi ọrụ HPMC n'ọtụtụ ngwa. Ịghọta mmekọrịta dị n'etiti viscosity na arụmọrụ HPMC dị oké mkpa maka ndị na-emepụta ihe iji chepụta usoro dị irè. Site n'iji nlezianya họrọ akara ule HPMC na ịchịkwa viscosity site na atụmatụ dị iche iche, ndị na-emepụta ihe nwere ike ịkwalite arụmọrụ ngwaahịa na izute ihe achọrọ ngwa ngwa.
Oge nzipu: Feb-29-2024