Hydroxypropylcellulose (HPC) bụ ihe dị mkpa cellulose ewepụtara nke a na-ejikarị na mpaghara ọgwụ, nri na ịchọ mma. Ngwa ya na nkwusioru bụ ihe a ma ama, tumadi site na nkwụsi ike ya, na-eme ka ọ kwụsie ike na ihe na-edozi ahụ iji kwalite nkwụsi ike nke nkwusioru.
Njirimara bụ isi nke hydroxypropylcellulose
Hydroxypropyl cellulose bụ nonionic cellulose ether nwetara site hydroxypropylation nke eke cellulose. A na-ewebata otu hydrophilic hydroxypropyl n'ime usoro kemịkalụ ya, na-enye ya ezigbo solubility na ihe na-eme ka mmiri dị n'ime. HPC nwere njirimara ndị a:
Ezigbo solubility: HPC nwere ike igbari na ma mmiri oyi na mmiri ọkụ, na-eme ngwọta doro anya na viscous.
Nnukwu biocompatibility: HPC nwere ezigbo biocompatibility na nsi dị ala, yabụ a na-eji ya na ụlọ ọrụ ọgwụ na nri.
Nkwụsi ike okpomọkụ siri ike: HPC nwere nkwụsi ike dị elu ma nwee ike ịnọgide na-eme ka ọ sie ike ma na-eme ka ọ dị ike n'ime oke okpomọkụ.
ndim mmetụta
Otu n'ime isi ọrụ nke HPC na nkwusioru bụ ịgba. Site n'ịgbakwụnye HPC kwesịrị ekwesị na nkwusioru ahụ, viscosity nke mmiri mmiri nwere ike ịbawanye nke ọma, si otú a na-ebelata ọsọ ọsọ nke ihe siri ike. Dị ka iwu Stokes si dị, nhazi ọsọ nke ụmụ irighiri ihe na-adaba na viscosity nke mmiri mmiri. Ya mere, site n'ịbawanye viscosity nke nkwusioru ahụ, nhazi nke irighiri ihe nwere ike igbu oge nke ọma na nkwụsi ike nke nkwusioru ahụ ka mma.
Mmetụta ịdị arọ nke HPC na-esite na ịdị arọ ya dị elu yana mmetụta ntinye n'etiti ụdọ molekụla. Mgbe HPC gbazere na mmiri, ụmụ irighiri akwara ogologo na-apụta ma na-ejikọta ibe ha na ngwọta, na-eme usoro netwọk dị mgbagwoju anya. Usoro netwọk a nwere ike ịbawanye viscosity nke ngwọta nke ọma, na-eme ka o sie ike maka ihe ndị siri ike ịkwaga na mmiri mmiri, si otú ahụ na-eme ka nkwụsi ike nke nkwusioru ahụ dịkwuo mma.
Mmetụta nkwụsi ike
Ọrụ ọzọ dị mkpa nke HPC bụ imeziwanye nkwụsi ike nke nkwusioru ahụ. Na mgbakwunye na mmetụta ya na-eme ka ọ sie ike, HPC nwekwara ezigbo ọrụ interfacial yana ikike ịmepụta oyi akwa mkpuchi nchebe. Enwere ike ịgbanye ụmụ irighiri ihe HPC n'elu ihe siri ike iji mepụta akwa gluu na-echebe iji gbochie ụmụ irighiri ihe site na ikpokọta na idozi.
Ngwunye nrapado a na-eme ka nkwusioru ahụ kwụsie ike site na mkparị electrostatic na mmetụta mgbochi siri ike. Nke mbụ, otu hydroxypropyl dị na molekul HPC nwere ike ịmepụta njikọ nke hydrogen na ụmụ irighiri mmiri, na-abawanye hydrophilicity nke elu ahụ ma na-eme ka mgbasa nke ihe ndị ahụ dị na mmiri. Nke abuo, ọnụnọ nke HPC molecular chains ga-etolite ihe mgbochi anụ ahụ na urughuru elu, na-egbochi kpọmkwem kọntaktị n'etiti ahụ, si otú ibelata urughuru mkpokọta na sedimentation.
Solubilization
Enweghi ike ileghara mmetụta solubilizing nke HPC na nkwusioru. Maka ụfọdụ ọgwụ na-adịghị mma soluble ma ọ bụ ihe ndị na-arụsi ọrụ ike, HPC nwere ike ịbawanye solubility ha na mmiri site na ịmepụta ogige nsonye molekụla ma ọ bụ micelles. Otu hydroxypropyl dị na molekul HPC nwere ike ịmepụta mmekọrịta na-adịghị ike (dị ka hydrogen bonds ma ọ bụ van der Waals Force) na ụmụ irighiri ihe na-adịghị ike soluble, si otú ahụ na-eme ka ọ dịkwuo ike na mmiri.
Site na mmetụta solubilization a, HPC nwere ike ọ bụghị naanị na-abawanye solubility nke ihe na-adịghị mma soluble na nkwusioru, kamakwa melite nkesa edo edo na mmiri mmiri, na-eme ka nkwụsi ike nke nkwusioru ahụ dịkwuo mma.
Ngwa
N'ụlọ ọrụ na-emepụta ọgwụ, a na-ejikarị HPC eme ihe n'ụdị nkwadebe ọgwụ dị iche iche dị ka nkwụsị ọnụ, injections, na nkwadebe anya. Dịka ọmụmaatụ, na nkwusioru ọnụ, HPC nwere ike melite nkwusioru na nkwụsi ike nke ọgwụ ahụ, na-ahụ na ọgwụ ahụ adịghị edozi n'oge nchekwa, si otú ahụ na-emeziwanye arụmọrụ na nchekwa nke ọgwụ ahụ. N'ime injections, HPC nwere ike ịbawanye bioavailability nke ọgwụ ma melite arụmọrụ ha site na solubilization.
N'ụlọ ọrụ nri, a na-ejikarị HPC na ngwaahịa nkwusioru dị ka mmiri ara ehi, ngwaahịa mmiri ara ehi na condiments. HPC nwere ike imeziwanye viscosity na nkwụsi ike nke nkwusioru, gbochie nhazi na stratification nke ihe siri ike, ma hụ na ịdị n'otu na uto nke ngwaahịa ahụ.
Hydroxypropylcellulose na-arụ ọrụ dị mkpa n'ịkwalite nkwụsi ike nkwusioru. Site ya ndim, stabilizing na solubilizing Njirimara, HPC nwere ike budata dịkwuo viscosity nke suspensions, belata edozi ọsọ nke siri ike ahụ, na-etolite a na-echebe gluu oyi akwa iji gbochie urughuru mkpokọta, na dịkwuo solubility nke emezighituri soluble bekee. Ngwongwo ndị a na-eme HPC n'ọtụtụ ebe n'ọhịa nke ọgwụ, nri na ihe ịchọ mma, na-aghọ akụkụ bụ isi iji meziwanye nkwụsi ike nke nkwusioru.
Oge nzipu: Jul-21-2024