HPMC (Hydroxypropyl Methylcellulose) bụ ihe eji eme ihe n'ọtụtụ ebe na mkpuchi na nkwadebe ọgwụ, na-emepụta ihe nkiri dị mma, na-agbatị, nkwụsi ike na nrapado. N'ihe gbasara mkpuchi, a na-ejikarị HPMC eme ihe na usoro mkpuchi mmiri, nke nwere ike ime ka adhesion nke mkpuchi na arụmọrụ ha dịkwuo mma.
1. Ihe ndị bụ isi nke HPMC
HPMC bụ ihe na-abụghị ionic cellulose nwere ihe pụrụ iche nke anụ ahụ na kemịkal. Na ngwọta, HPMC nwere ike na-emepụta anụ ahụ na kemịkalụ mmekọrịta na substrate elu site molekụla agbụ, si otú akpụ a film na ụfọdụ n'ibu ike na elasticity. Ihe nkiri a nwere mgbanwe dị mma na nkwụsị mgbawa, nke nwere ike inyere mkpuchi ahụ aka ime ka ọdịdị elu nke mkpụrụ ahụ dịkwuo mma, si otú a na-eme ka adhesion dịkwuo mma.
The film-akpụ usoro nke HPMC bụ tumadi metụtara mkpokọta na cross-njikọ e ji mara ya molekụla agbụ. Otu hydroxypropyl na methyl dị na molekul HPMC na-eme ka ọ bụrụ hydrophilic na hydrophobic na ngwọta. Nke a amphiphilicity na-enyere HPMC aka ịgbakọta onwe ya n'ime a ok Ọdịdị na mmiri dabeere na mkpuchi usoro, si otú ahụ na-eme ka ígwè ike na adhesion nke mkpuchi.
2. Ihe ndị na-emetụta ike adhesion nke mkpuchi nke HPMC
Ntinye nke HPMC:
Ntinye nke HPMC na mkpuchi nwere mmetụta dị ukwuu na ike adhesion nke mkpuchi. Ọnụ ọgụgụ dị elu nke HPMC na-abawanye viscosity nke mkpuchi ma na-eme ka ihe na-emepụta ihe nkiri na-eme ka ọ dịkwuo mma, si otú ahụ na-eme ka adhesion nke mkpuchi ahụ dịkwuo elu. Otú ọ dị, nnukwu mkpokọta HPMC nwere ike ime ka ọkpụrụkpụ mkpuchi na-enweghị isi ma na-emetụta mmetụta adhesion. Nnyocha egosiwo na ntinye HPMC kwesịrị ekwesị nwere ike ime ka mkpuchi ahụ dịkwuo mma n'elu ala, na oke dị ala ma ọ bụ dị elu ga-enwe mmetụta na-adịghị mma na adhesion.
Uru pH na okpomọkụ nke ngwọta:
The solubility nke HPMC na ya film-akpụ Njirimara na-emetụta pH uru na okpomọkụ. Na gburugburu acidic ma ọ bụ alkaline, solubility nke mkpụrụ ndụ HPMC na-agbanwe, nke n'aka nke ya na-emetụta ike adhesion nke mkpuchi. N'ikwu okwu n'ozuzu, ọnọdụ pH na-agafeghị oke nwere ike idowe nkwụsi ike nke HPMC ma kwalite njikọ ya na elu mkpụrụ. Na mgbakwunye, okpomọkụ na-emetụtakwa ngagharị na ihe nkiri na-eme ọsọ nke yinye molekul HPMC. Okpomọkụ dị elu nwere ike na-eme ka ọnụọgụ mgbanwe nke ngwọta dị ngwa ngwa ma kwe ka mkpuchi ahụ na-etolite ngwa ngwa, ma ọ nwere ike ime ka esemokwu dị n'ime nke oyi akwa ihe nkiri ahụ dịkwuo elu, si otú ahụ na-emetụta ike adhesion nke mkpuchi.
Arọ molikula nke HPMC:
The molekụla arọ nke HPMC ozugbo emetụta ya rheological Njirimara na film-akpụ Njirimara na mkpuchi. HPMC na ibu molekul ibu nwere ike na-etolite a ike film oyi akwa, si otú na-amụba adhesion nke mkpuchi, ma ya solubility na fluidity bụ ogbenye, nke nwere ike mfe iduga ogbenye larịị nke mkpuchi na a siri ike elu. N'ụzọ megidere nke ahụ, ọ bụ ezie na HPMC nwere obere molecular arọ nwere mma solubility na fluidity, ya n'ibu ike mgbe film e guzobere bụ ala, na mma nke adhesion ike nke mkpuchi na-ejedebeghị. Ya mere, ịhọrọ HPMC nwere ịdị arọ molekụla dabara adaba nwere ike ime ka nguzozi dị n'etiti arụmọrụ mkpuchi na nrapado.
Mmetụta siri ike nke HPMC:
Dị ka a thickener, HPMC nwere ike budata dịkwuo viscosity nke usoro na mkpuchi, si otú eme ka fluidity na uniformity nke mkpuchi. Nhazi nke otu akwa na akwa ihe nkiri dị n'elu nke mkpụrụ bụ isi ihe na-eme ka ike nke adhesion dịkwuo mma, na HPMC nwere ike igbochi mkpuchi ahụ site na sagging ma ọ bụ akara nrịba n'elu nke mkpụrụ ahụ site n'ịgbanwe viscosity nke mkpuchi, si otú ahụ. na-eme ka arụmọrụ adhesion nke mkpuchi dịkwuo elu.
3. Ngwa nke HPMC dị iche iche substrates
Ngwa igwe:
N'elu elu igwe, adhesion nke mkpuchi na-emetụtakarị ịdị nro nke elu igwe na oyi akwa oxide. HPMC na-eme ka ihe na-emepụta ihe nkiri na mgbanwe mgbanwe nke mkpuchi ahụ dịkwuo mma, na-eme ka mkpuchi ahụ dịkwuo mma na elu igwe, na-ebelata ntụpọ interface n'etiti mkpuchi na metal, si otú ahụ na-eme ka adhesion nke mkpuchi. Na mgbakwunye, HPMC nwekwara ike na-arụ ọrụ synergistically na ndị ọzọ tackifiers aka n'ihu welie n'ibu ike nke mkpuchi.
Ngwa plastik:
Ihe ndị dị na rọba na-enwekarị ike dị ala, ọ na-esirikwa ike mkpuchi ahụ ịrapagidesi ike na elu ha. N'ihi usoro ihe omimi ya pụrụ iche, HPMC nwere ike ịmepụta njikọ hydrogen siri ike n'elu plastik, si otú ahụ na-eme ka adhesion nke mkpuchi ahụ dịkwuo mma. N'otu oge ahụ, dị ka thickener, HPMC nwere ike ebuli larịị nke mkpuchi n'elu plastic ma zere shrinkage ma ọ bụ cracking nke mkpuchi.
Ngwa seramiiki na iko:
Elu nke ihe inorganic dị ka ceramik na iko dị ezigbo ụtọ, ọ na-esikwa ike maka mkpuchi ahụ ijigide nke ọma. HPMC na-eme ka wettability na adhesion nke mkpuchi n'elu ihe ndị a na-eme ka ọ bụrụ ihe enyemaka na-emepụta ihe nkiri na mkpuchi. Na mgbakwunye, ikike imepụta ihe nkiri nke HPMC nwere ike mejupụta obere mgbawa nke mkpuchi ahụ na-eme n'elu mkpụrụ ahụ wee welie nchikota n'ozuzu ya.
4. Oke ngwa na ntụzịaka nkwalite nke HPMC
Ọ bụ ezie na HPMC nwere mmetụta dị ukwuu n'ịkwalite adhesion nke mkpuchi, ọ ka nwere ụfọdụ njedebe na ngwa bara uru. Dịka ọmụmaatụ, HPMC nwere mmetụta dị nta na ịkwalite nkwụsi ike nke mkpuchi na gburugburu ebe dị oke egwu, karịsịa n'okpuru oke iru mmiri ma ọ bụ ọnọdụ okpomọkụ dị elu, ebe ihe ndị na-emepụta ihe nkiri ya nwere ike ibelata na mkpuchi ahụ na-adịkarị mfe ịdapụ. Ya mere, ndị na-eme nchọpụta na-enyocha ụzọ isi meziwanye arụmọrụ nke HPMC site na ngbanwe kemịkalụ ma ọ bụ iji ihe ndị ọzọ polymer jikọta. Dịka ọmụmaatụ, site n'iwebata ndị ọrụ na-ejikọta cross-links ma ọ bụ ihe ntanye ike ndị ọzọ dị elu, enwere ike ịkwalite nkwụsi ike nke HPMC n'okpuru ọnọdụ siri ike.
Dị ka ihe mgbakwunye mkpuchi dị mkpa, HPMC nwere ike melite ike adhesion nke mkpuchi. Ngwongwo ya na-emepụta ihe nkiri, ihe na-eme ka ọ sie ike, yana mmekọrịta anụ ahụ na kemịkal na elu mkpụrụ bụ isi ihe na-arụ ọrụ ya. Site n'iji ezi uche na-edozi ntinye uche, ịdị arọ molecular, na ọnọdụ gburugburu ebe obibi nke HPMC, enwere ike ịkwalite mmetụta ya na imeziwanye ihe mkpuchi mkpuchi. N'ọdịnihu, nkwalite arụmọrụ nke HPMC ga-eweta ohere ngwa ngwa na ụlọ ọrụ mkpuchi, karịsịa n'ọhịa nke mkpuchi gburugburu ebe obibi ọhụrụ.
Oge nzipu: Ọktoba 11-2024