HPMC bụ polymer synthetic nke sitere na cellulose. N'ihi ihe ndị na-eme ka ọ dị mma, na-eme ka ọ dịkwuo mma na ịmepụta ihe nkiri, a na-ejikarị ya na nkà mmụta ọgwụ, nri, ihe ịchọ mma na ụlọ ọrụ ndị ọzọ. Ịmụ àgwà viscosity ya dị oke mkpa iji bulie arụmọrụ ya na ngwa dị iche iche.
1. Ntụ viscosity:
Viscometer na-agbanwe agbanwe: Viscometer na-atụgharị na-atụ ike nke achọrọ iji tụgharịa spindle na ọsọ ọsọ mgbe a na-emikpu n'ime ihe nlele. Site n'ịgbanwe geometry na ọsọ ntụgharị nke spindle, enwere ike ikpebi viscosity n'ọnụego shear dị iche iche. Usoro a na-enyere aka ịkọwapụta viscosity HPMC n'okpuru ọnọdụ dị iche iche.
Capillary Viscometer: Viscometer nke capillary na-atụfe mmiri mmiri si na tube capillary n'okpuru mmetụta nke ike ndọda ma ọ bụ nrụgide. A na-amanye ihe ngwọta HPMC site na tube capillary ma gbakọọ viscosity dabere na ọnụego nrịba na nrụgide nrụgide. Enwere ike iji usoro a mụọ viscosity HPMC na ọnụ ọgụgụ shear dị ala.
2. Nlegharị anya:
Rheometry Shear Dynamic (DSR): DSR na-atụle nzaghachi nke ihe na nrụrụ shiee ike. A na-etinye ihe nlele HPMC na nrụgide oscillatory shiee ma tụọ ụdị nsogbu ndị si na ya pụta. Enwere ike mara omume viscoelastic nke ngwọta HPMC site n'ịtụle viscosity dị mgbagwoju anya (η*) yana modul nchekwa (G') na modul ọnwụ (G").
Nnwale mgbake na mgbake: Nnwale ndị a gụnyere idobe ihe nlele HPMC na nrụgide ma ọ bụ nhụsianya ruo ogologo oge (oge na-akpụ akpụ) wee nyochaa mgbake na-esote mgbe ahụ kwụsịrị nrụgide ma ọ bụ nsogbu. Àgwà mgbake na mgbake na-enye nghọta na njirimara viscoelastic nke HPMC, gụnyere nrụrụ ya na ike mgbake.
3. Nleba anya na ihe ọmụmụ dabere na ọnọdụ okpomọkụ:
Nyochaa nleba anya: A na-eme nha viscosity n'ọtụtụ ebe mkpokọta HPMC iji mụọ mmekọrịta dị n'etiti viscosity na mkpokọta polymer. Nke a na-enyere aka ịghọta ịdị arọ nke polymer na omume dabere na uche ya.
Nyocha okpomọkụ: A na-eme nha viscosity na okpomọkụ dị iche iche iji mụọ mmetụta okpomọkụ na viscosity HPMC. Ịghọta ịdabere na ọnọdụ okpomọkụ dị oke mkpa maka ngwa ebe HPMC na-enweta mgbanwe okpomọkụ, dị ka usoro ọgwụ.
4. Ntụle ịdị arọ nke molikula:
Chromatography Mwepu nha (SEC): SEC na-ekewa ụmụ irighiri ihe polymer dabere na nha ha na ngwọta. Site n'ịtụle profaịlụ elution, enwere ike ikpebi nkesa arọ molekul nke ihe nlele HPMC. Ịghọta mmekọrịta dị n'etiti ịdị arọ molekụla na viscosity dị oke mkpa maka ịkọ omume rheological nke HPMC.
5. Nlereanya na ịme anwansị:
Ụdị usoro iwu: Ụdị usoro ihe dị iche iche, dị ka ihe nlereanya Carreau-Yasuda, Cross model ma ọ bụ iwu iwu ike, nwere ike iji kọwaa àgwà viscosity nke HPMC n'okpuru ọnọdụ ịkwa akwa dị iche iche. Ụdị ndị a na-ejikọta paramita dị ka ọnụ ọgụgụ shear, ntinye uche, na ịdị arọ molecular iji buru amụma nke ọma viscosity.
Mgbakọ Mgbakọ: Mgbakọ Fluid Dynamics (CFD) simulations na-enye nghọta n'omume na-erugharị nke ngwọta HPMC na geometries mgbagwoju anya. Site n'iji ọnụọgụ ọnụọgụ na-edozi nha nha na-achịkwa nke mmiri mmiri, ịme anwansị CFD nwere ike ibu amụma nkesa viscosity na usoro eruba n'okpuru ọnọdụ dị iche iche.
6. N'ime ọnọdụ na in vitro ọmụmụ:
Ntụnye n'ime ọnọdụ: Usoro n'ime ọnọdụ gụnyere ịmụ mgbanwe viscosity ozugbo na gburugburu ma ọ bụ ngwa. Dịka ọmụmaatụ, na usoro ọgwụ, nha ọnọdụ nwere ike nyochaa mgbanwe viscosity n'oge mgbasa mbadamba ma ọ bụ ngwa gel.
Nnwale in vitro: Nnwale in vitro na-eme ka ọnọdụ physiological iji nyochaa omume viscosity nke usoro dabere na HPMC ezubere maka nchịkwa ọnụ, anya, ma ọ bụ n'elu. Nnwale ndị a na-enye ozi bara uru na arụmọrụ na nkwụsi ike nke nhazi n'okpuru ọnọdụ ndu dị mkpa.
7. Advanced teknụzụ:
Microrheology: Usoro microrheology, dị ka ịgbasa ọkụ dị ike (DLS) ma ọ bụ microrheology tracking particle (PTM), na-enye ohere ịchọpụta njirimara viscoelastic nke mmiri dị mgbagwoju anya na ọnụ ọgụgụ microscopic. Usoro ndị a nwere ike inye nghọta gbasara omume HPMC n'ọkwa molekul, na-emeju nha rheological macroscopic.
Igwe Igwe Igwe Igwe Igwe Ọdụdọ Nuklia (NMR) Spectroscopy: NMR spectroscopy nwere ike iji mụọ ihe omimi molekul na mmekọrịta nke HPMC na ngwọta. Site na nyochaa mgbanwe kemịkalụ na oge ezumike, NMR na-enye ozi bara uru na mgbanwe mgbanwe HPMC yana mmekọrịta polymer-solvent nke na-emetụta viscosity.
Ịmụ àgwà viscosity nke HPMC chọrọ usoro mmụta dị iche iche, gụnyere usoro nnwale, nhazi usoro, na ụzọ nyocha dị elu. Site n'iji nchikota nke viscometry, rheometry, molecular analysis, modeling, na usoro dị elu, ndị nchọpụta nwere ike nweta nghọta zuru oke banyere njirimara rheological nke HPMC ma kwalite arụmọrụ ya na ngwa dị iche iche.
Oge nzipu: Feb-29-2024