Hydroxypropyl methylcellulose (Hypromellose), nke a makwaara dị ka hypromellose, bụ ntụ ntụ cellulose na-acha ọcha na-acha ọcha ma ọ bụ granule, nke nwere njirimara nke ịbụ onye soluble na mmiri oyi na-adịghị ike na mmiri ọkụ dị ka methyl cellulose. Otu hydroxypropyl na otu methyl jikọtara ya na mgbanaka glucose anhydrous nke cellulose site na ether bond, nke bụ ụdị nke na-abụghị ionic cellulose agwakọta ether. Ọ bụ semisynthetic, anaghị arụ ọrụ, polymer viscoelastic a na-ejikarị dị ka mmanu na ophthalmology, ma ọ bụ dị ka ihe excipient ma ọ bụ ụgbọ n'ime ọgwụ ọnụ.
nkwadebe
Mpempe akwụkwọ mpempe akwụkwọ nke kraft akwụkwọ nke enwetara site na osisi pine nwere ọdịnaya alfa cellulose nke 97%, viscosity dị n'ime nke 720 ml/g, na nkezi eriri ogologo nke 2.6 mm na-emikpu na 49% NaOH aqueous solution na 40 ° C. 50 sekọnd; A na-apịpịa mkpụrụ osisi ahụ a rụpụtara iji wepụ ihe karịrị 49% mmiri NaOH iji nweta cellulose alkali. The arọ ruru nke (49% NaOH aqueous ngwọta) na (ike ọdịnaya na pulp) na impregnation nzọụkwụ bụ 200. The arọ ruru nke (NaOH ọdịnaya na alkali cellulose si otú enwetara) na (ihe siri ike na pulp) bụ. 1.49. A na-etinye cellulose alkali ahụ (20 n'arọ) n'ime ihe na-eme ka ọ bụrụ ihe na-akpali akpali, wee wepụ ya na nitrogen iji wepụ oxygen zuru ezu na reactor. Na-esote, a na-eme mkpali n'ime ka ọ na-achịkwa okpomọkụ na reactor na 60 Celsius. Mgbe ahụ, a na-agbakwunye 2.4 n'arọ nke dimethyl ether, a na-achịkwa okpomọkụ dị na reactor ka ọ debe ya na 60 Celsius. Mgbe ịgbakwunye dimethyl ether, tinye dichloromethane ka molar ratio nke (dichloromethane) ka (NaOH akụrụngwa na alkaline cellulose) bụ 1.3, na tinye propylene oxide ime (propylene oxide) na (na pulp) The arọ ruru nke siri ike ọdịnaya) gbanwere ka ọ bụrụ 1.97, ebe a na-achịkwa okpomọkụ dị na reactor site na 60 Celsius ruo 80 Celsius. Mgbe mgbakwunye nke methyl chloride na propylene oxide, a na-achịkwa okpomọkụ dị na reactor site na 80 Celsius ruo 90 Celsius. Ọzọkwa, a na-aga n'ihu na mmeghachi omume ahụ na 90 Celsius maka nkeji 20. Mgbe ahụ, a na-ewepụ gas ahụ site na reactor, wee wepụ hydroxypropyl methylcellulose crude na reactor. Okpomọkụ nke crude hydroxypropyl methylcellulose n'oge ewepụtara bụ 62 Celsius. The cumulative 50% urughuru size na urughuru size nkesa dabere na cumulative arọ kpebisiri ike dabere na ruru nke crude hydroxypropyl methylcellulose na-agafe oghere nke ise sieves, ọ bụla sieve nwere a dị iche iche oghere size, tụrụ. N'ihi ya, nkezi urughuru size nke keadighi rarii ahụ bụ 6.2 mm. E webatara crude hydroxypropyl methylcellulose n'ime kneader biaxial na-aga n'ihu (KRC kneader S1, L/D=10.2, olu dị n'ime 0.12 lita, ọsọ ntụgharị 150 rpm) na ọnụego 10 kg / hr, wee nweta ire ere. nke crude hydroxypropyl methylcellulose. Nkezi urughuru nha bụ 1.4 mm dị ka tụrụ n'otu aka ahụ iji sieves nke 5 dị iche iche oghere nha. Na decomrated crude hydroxypropyl methylcellulose na tank na jaket okpomọkụ akara, tinye mmiri ọkụ na 80 Celsius C na ihe dị otú ahụ (The arọ ruru nke ego nke cellulose) na (ngụkọta ego nke slurry) gbanwere na 0.1, na enwetara slurry. A na-akpali slurry ahụ na okpomọkụ nke 80 Celsius C mgbe niile maka nkeji 60. Na-esote, a na-enyefe slurry ahụ n'ime ihe nzacha nrụgide rotary preheated (ngwaahịa nke BHS-Sonthofen) nwere ọsọ ntụgharị nke 0.5 rpm. Okpomọkụ nke slurry bụ 93 Celsius. A na-enye slurry ahụ site na iji mgbapụta, na nrụgide mgbapụta nke mgbapụta ahụ bụ 0.2 MPa. Ogo oghere nke nzacha nke nzacha nrụgide rotary bụ 80 μm, ebe nzacha ahụ bụ 0.12 m 2. A na-atụgharị slurry a na-enye na nzacha nrụgide rotary ka ọ bụrụ achicha nzacha site na nzacha nzacha. Mgbe enyechara uzuoku nke 0.3 MPa na achicha ahụ wee nweta ya, a na-enye mmiri ọkụ na 95 Celsius C n'ụdị nke na nha nha (mmiri ọkụ) na (ọdịnaya siri ike nke hydroxypropyl methylcellulose mgbe ịsachara) bụ 10.0, wee nyochaa site na nyo. A na-enye mmiri ọkụ site na mgbapụta na nkwụsị nke 0.2 MPa. Mgbe e nyechara mmiri ọkụ ahụ, a na-enye uzuoku nke 0.3 MPa. Mgbe ahụ, a na-ewepụ ngwaahịa a na-asacha n'elu nzacha site na scraper ma wepụ ya na igwe ịsa ahụ. A na-eme usoro site na inye slurry nri ruo n'ịwụsa ngwaahịa a sachara. N'ihi nha site na iji ụdị hygrometer ihicha okpomọkụ, ọdịnaya mmiri nke ngwaahịa a sachara bụ 52.8%. Ngwaahịa a sachara nke ewepụtara na nzacha nrụgide rotary bụ akpọnwụọ site na iji igwe nkụ ikuku na 80° C., ma kụrie ya na igwe igwe ihe mmeri iji nweta hydroxypropyl methylcellulose.
ngwa
A na-eji ngwaahịa a dị ka thickener, dispersant, ihe nkedo, emulsifier na stabilizer na ụlọ ọrụ akwa. A na-ejikwa ya na resin sịntetik, petrochemical, ceramics, akwụkwọ, akpụkpọ anụ, ọgwụ, nri, ihe ịchọ mma na ụlọ ọrụ ndị ọzọ.
Oge nzipu: Nov-15-2022