Ọkwa ọgwụ Hydroxypropyl Methylcellulose (HPMC)

Ọkwa ọgwụ Hydroxypropyl Methylcellulose (HPMC) bụ ngwa ahịa ọgwụ a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ. Ọ bụ ọkara sịntetik, inert, cellulose ether na-agbaze mmiri, nke a na-emezi site na cellulose eke. HPMC nwere ezigbo ihe nkiri-akpụ, ndim, adhesion, nkwusioru na mgbochi-caking Njirimara, ya mere o nwere mkpa ngwa uru na ọgwụ preparations.

1. Ihe ndị bụ isi nke HPMC
A na-eme HPMC site na iji hydroxypropyl na methoxy nọchie akụkụ hydroxyl nke cellulose. Ọdịdị molekụla ya nwere ihe abụọ nọchiri anya ya, hydroxypropyl na methyl, ya mere a na-akpọ ya hydroxypropyl methylcellulose. HPMC nwere ezigbo solubility na mmiri, na mgbe mgbasa, ọ na-etolite a transperent viscous ngwọta. Ka ntinye uche na-abawanye, viscosity na-abawanye. Na mgbakwunye, HPMC nwere ezigbo nkwụsi ike nke okpomọkụ na nkwụsi ike kemịkalụ, ma nwee nnabata dị mma na ngwọta acid, alkali na nnu.

2. Ngwa nke HPMC na pharmaceuticals
A na-eji HPMC eme ihe na ụlọ ọrụ ọgwụ, ọkachasị n'akụkụ ndị a:

a. Ihe mkpuchi mbadamba
HPMC, dị ka ihe mkpuchi maka mbadamba nkume, nwere ike kpuchie uto ọjọọ nke ọgwụ ọjọọ nke ọma, mee ka ọdịdị ọgwụ dịkwuo mma, ma nwee mmetụta nke mmiri na-egbochi oxidation. Na mgbakwunye, ọ nwere ike ịgbatị oge ntọhapụ nke ọgwụ na tract gastrointestinal, si otú ahụ nweta mmetụta ntọhapụ na-adịgide adịgide ma ọ bụ na-achịkwa.

b. Thickers na ihe nkedo
Mgbe ị na-akwadebe suspensions, emulsions, capsules na ndị ọzọ nkwadebe, HPMC, dị ka a thickener na ihe nkedo, nwere ike melite nkwụsi ike na uniformity nke preparations. N'otu oge ahụ, HPMC nwekwara ike welie ike na n'ibu ike nke mbadamba nkume iji hụ na ọgwụ adịghị mfe agbaji n'oge mmepụta na njem.

c. Nkwadebe na-achịkwa na nkwado-mwepu
A na-ejikarị HPMC eme ihe n'ịkwado ntọhapụ na nkwado nkwado n'ihi na gel Layer ọ na-emepụta nwere ike igbochi mmiri ịbanye na mbadamba nkume, nke mere na a na-achịkwa mgbasa na ntọhapụ nke ọgwụ ahụ nke ọma. Site n'ịgbanwe viscosity na usoro onunu ogwu nke HPMC, enwere ike ịchịkwa ọnụego ọgwụ ahụ n'ụzọ ziri ezi, enwere ike ịgbatị oge ọgwụ ahụ, yana enwere ike belata ugboro ole ọgwụ.

d. Dị ka ihe ndochi
N'ime nkwadebe capsule, enwere ike iji HPMC dị ka ihe ndochi iji mejuo capsules oghere. E jiri ya tụnyere capsules gelatin ọdịnala, capsules HPMC nwere uru nke ịbụ ihe sitere na osisi na enweghị ihe anụmanụ, yabụ na ha dabara maka ndị anaghị eri anụ na ndị ọrịa nwere ihe mgbochi okpukpe.

3. Nchekwa nke HPMC
Dị ka ihe mgbakwunye ọgwụ, HPMC nwere ezigbo bioocompatibility na nchekwa. A naghị emebi ya site na enzymes digestive na ahụ mmadụ ma na-esi na ahụ pụta site na eriri afọ, n'ihi ya, ọ naghị etinye aka na usoro metabolic ọgwụ na ọ dịghị emepụta mmetụta ndị na-egbu egbu. A na-eji HPMC eme ihe n'ọtụtụ ebe n'ụdị dị iche iche nke ọnụ, n'elu na nkwadebe injectable ma ndị pharmacopoeias ghọtara ya gburugburu ụwa.

4. Atụmanya ahịa
Site na mmepe na-aga n'ihu nke ụlọ ọrụ ọgwụ, ihe ndị a chọrọ maka ịdị mma na nchekwa ọgwụ na-abawanye. N'ihi njirimara anụ ahụ na kemịkal pụrụ iche yana ezigbo nchekwa, HPMC nwere atụmanya ngwa sara mbara na nkwadebe ọgwụ ọhụrụ. Karịsịa na ngalaba nke ntọhapụ a na-achịkwa na nkwado ntọhapụ, ọgwụ nje na ọgwụ maka ndị mmadụ pụrụ iche (dị ka ndị anaghị eri anụ), ọchịchọ maka HPMC ga-aga n'ihu na-eto eto.

Dị ka a multifunctional ọgwụ excipient, pharmaceutical ọkwa hydroxypropyl methylcellulose arụwo ọrụ dị mkpa na ụlọ ọrụ na-emepụta ọgwụ na a ga-anọgide na-eji na-ewu ewu n'ọdịnihu.