Ihe mgbakwunye ọgwụ Cellulose Ether

Natural cellulose ether bụ okwu n'ozuzu maka usoro nkeihe mmepụta celluloseemepụtara site na mmeghachi omume nke cellulose alkali na etherifying n'okpuru ọnọdụ ụfọdụ. Ọ bụ ngwaahịa nke hydroxyl dị na cellulose macromolecules na-eji akụkụ ether dochie akụkụ ma ọ bụ kpamkpam. A na-eji ether cellulose eme ihe n'ubi mmanụ ala, ihe owuwu ụlọ, mkpuchi, nri, ọgwụ, na kemịkalụ kwa ụbọchị. N'ebe dị iche iche, ngwaahịa-ọkwa ọgwụ bụ isi n'etiti etiti na elu-ọgwụgwụ ubi nke ụlọ ọrụ, na elu gbakwunyere uru. N'ihi ezigbo mma chọrọ, mmepụta nke cellulose ether ọkwa ọgwụ na-esikwa ike. Enwere ike ịsị na ogo ngwaahịa ngwaahịa ọgwụ nwere ike na-anọchite anya ike teknụzụ nke ụlọ ọrụ cellulose ether. A na-agbakwunye cellulose ether dị ka ihe mgbochi, ihe matriks na thickener iji mee ka mbadamba matrix na-adịgide adịgide, ihe mkpuchi gastric-soluble, ihe mkpuchi microcapsule na-adịgide adịgide, ihe nkiri ihe nkiri ọgwụ na-adịgide adịgide, wdg.

sodium carboxymethyl cellulose:

Carboxymethyl cellulose sodium (CMC-Na) bụ cellulose ether dị iche iche nwere mmepụta na oriri kachasị ukwuu n'ụlọ na ná mba ọzọ. Ọ bụ ether cellulose ionic nke sitere na owu na osisi sitere na alkalization na etherification na chloroacetic acid. CMC-Na bụ ihe mgbakwunye ọgwụ na-ejikarị eme ihe. A na-ejikarị ya eme ihe dị ka ihe nkedo maka nkwadebe siri ike, ihe na-eme ka ọ dị arọ, ihe na-eme ka ọ dị arọ, na onye na-akwụsịtụ maka nkwadebe mmiri. A pụkwara iji ya mee ihe dị ka matriks na-edozi mmiri na ihe na-emepụta ihe nkiri. A na-ejikarị ya dị ka ihe nkiri ihe nkiri ọgwụ akwadoro yana mbadamba matriks ntọhapụ na-akwado nkwado ntọhapụ (achịkwa).

Na mgbakwunye na sodium carboxymethylcellulose dị ka ọgwụ excipient, croscarmellose sodium nwekwara ike iji dị ka ọgwụ excipient. Croscarmellose sodium (CCMC-Na) bụ ngwaahịa na-adịghị edozi mmiri nke carboxymethylcellulose na-emeghachi omume na onye na-ahụ maka crosslinking na ụfọdụ okpomọkụ (40-80 ° C) n'okpuru ọrụ nke inorganic acid catalyst ma dị ọcha. Dị ka onye na-emekọrịta ihe, enwere ike iji propylene glycol, anhydride succinic, anhydride maleic na adipic anhydride mee ihe. A na-eji Croscarmellose sodium mee ihe dị ka ihe na-emebi emebi maka mbadamba nkume, capsules na granules na nkwadebe ọnụ. Ọ na-adabere na mmetụta capillary na ọzịza iji gbasaa. Ọ nwere ezigbo mkpakọ na ike mgbasa siri ike. Nnyocha e mere egosiwo na ọzịza nke croscarmellose sodium n'ime mmiri dị ukwuu karịa nke ndị na-agbasasịkarị dị ka carmellose sodium na-enweghị dochie anya na microcrystalline cellulose hydrated.

Methylcellulose:

Methyl cellulose (MC) bụ otu ether na-abụghị ionic cellulose nke sitere na owu na osisi site na alkalization na methyl chloride etherification. Methylcellulose nwere oke mmiri solubility ma kwụsie ike na pH2.0 ~ 13.0. A na-eji ya n'ọtụtụ ebe na ihe ndị na-emepụta ọgwụ, a na-ejikwa ya na mbadamba sublingual, injections intramuscular, nkwadebe ophthalmic, capsules ọnụ, nkwụsị ọnụ, mbadamba ọnụ na nkwadebe n'elu. Na mgbakwunye, na nkwadebe ntọhapụ na-adịgide adịgide, enwere ike iji MC dị ka hydrophilic gel matrix na-akwado mwepụta, ihe mkpuchi gastric-soluble, ihe mkpuchi microcapsule na-adịgide adịgide, ihe nkiri ihe nkiri ọgwụ na-adịgide adịgide, wdg.

Hydroxypropyl methyl cellulose:

Hydroxypropyl methylcellulose (HPMC) bụ ether na-abụghị ionic cellulose agwakọta nke sitere na owu na osisi site na alkalization, propylene oxide na methyl chloride etherification. Ọ na-esi ísì ụtọ, enweghị ụtọ, adịghị egbu egbu, soluble na mmiri oyi na gelled na mmiri ọkụ. Hydroxypropyl methylcellulose bụ cellulose agwakọta ether iche iche nke mmepụta, usoro onunu ogwu na àgwà ya na-abawanye ngwa ngwa na China n'ime afọ 15 gara aga. Ọ bụkwa otu n'ime ihe ndị a na-eji ọgwụ eme ihe n'ụlọ na mba ọzọ. afọ nke akụkọ ihe mere eme. Ugbu a, ngwa nke HPMC na-egosipụtakarị n'akụkụ ise ndị a:

Otu dị ka ihe nkedo na nkewa. Dị ka ihe na-ekekọta, HPMC nwere ike ime ka ọgwụ ahụ dị mfe mmiri, ọ pụkwara ịgbasa ọtụtụ narị ugboro mgbe ọ na-amịkọrọ mmiri, ya mere ọ nwere ike ime ka ọnụego mgbasa ma ọ bụ ntọhapụ nke mbadamba nkume ahụ dịkwuo mma. HPMC nwere ike viscosity, nke nwere ike welie urughuru viscosity na melite compressibility nke akụrụngwa na crisp ma ọ bụ kenkuwa udidi. Enwere ike iji HPMC nwere obere viscosity dị ka ihe nkedo na disintegrant, na ndị nwere nnukwu viscosity nwere ike iji naanị dị ka ihe nkedo.

Nke abụọ dị ka ihe ntọhapụ na-akwado ma na-achịkwa maka nkwadebe ọnụ. HPMC bụ ihe matriks hydrogel nke a na-ejikarị eme ihe na nkwado nkwado nkwado. Enwere ike iji ọkwa viscosity dị ala (5-50mPa·s) HPMC dị ka onye na-ekekọta, viscosifier na onye nkwusioru, yana ọkwa viscosity dị elu (4000-100000mPa·s) HPMC nwere ike iji dozie ihe ngwakọta ihe na-egbochi ihe maka capsules, matrix hydrogel. Mbadamba ụrọ agbatịla agbatị. HPMC bụ soluble na eriri afọ eriri afọ, nwere uru nke ezigbo mkpakọ, ezigbo fluidity, ike ibu ọgwụ ike, na ọgwụ ntọhapụ na-adịghị emetụta PH. Ọ bụ ihe dị oke mkpa na-ebu ihe na-ebu hydrophilic na sistemu nkwado nkwado na-adịgide adịgide ma na-ejikarị ya dị ka hydrophilic gel matrix na ihe mkpuchi maka nkwadebe ntọhapụ na-adịgide adịgide, yana ihe enyemaka maka nkwadebe mmiri na-ese n'elu afọ na nkwadebe ihe nkiri ọgwụ na-adịgide adịgide.

Nke atọ dị ka ihe mkpuchi na-emepụta ihe nkiri. HPMC nwere ezigbo ihe na-emepụta ihe nkiri. Ihe nkiri a na-emepụta ya bụ otu, nke doro anya na nke siri ike, ọ dịghịkwa mfe ịrapara n'oge mmepụta. Karịsịa maka ọgwụ ndị dị mfe ịmịkọrọ mmiri ma na-ejighị n'aka, iji ya dị ka oyi akwa dịpụrụ adịpụ nwere ike ime ka nkwụsi ike nke ọgwụ ahụ dịkwuo mma ma gbochie ihe nkiri ahụ na-agbanwe agba. HPMC nwere nkọwa viscosity dị iche iche. Ọ bụrụ na ahọpụtara ya nke ọma, ịdị mma na ọdịdị nke mbadamba nkume mkpuchi dị elu karịa ihe ndị ọzọ. Ntinye uche nke mbụ bụ 2% ruo 10%.

Nke anọ dị ka ihe capsule. N'afọ ndị na-adịbeghị anya, n'ihi ọrịa na-efe efe nke anụmanụ zuru ụwa ọnụ na-efe efe ugboro ugboro, ma e jiri ya tụnyere gelatin capsules, capsules nke akwukwo nri aghọwo onye ọhụrụ nke ụlọ ọrụ ọgwụ na nri. Pfizer nke United States ewepụtala HPMC nke ọma n'ime osisi eke na kwadoo capsules akwukwo nri VcapTM. N'iji ya na capsules oghe gelatin ọdịnala, capsules osisi nwere uru nke ngbanwe zuru oke, enweghị ihe egwu nke mmeghachi omume njikọ na nkwụsi ike dị elu. Ọnụego ntọhapụ ọgwụ ahụ kwụsiri ike, na ndịiche dị n'otu n'otu pere mpe. Mgbe ịgbasa n'ime ahụ mmadụ, ọ naghị etinye aka na ya ma nwee ike ịpụpụ ihe ahụ na-esi na ahụ pụta. N'ihe banyere ọnọdụ nchekwa, mgbe ọtụtụ ule gasịrị, ọ fọrọ nke nta ka ọ bụrụ na ọ naghị emebi emebi n'okpuru ọnọdụ iru mmiri dị ala, na njirimara nke shei capsule ka kwụsiri ike n'okpuru ọnọdụ iru mmiri dị elu, na ihe ngosi nke capsules osisi anaghị emetụta n'okpuru oke nchekwa. ọnọdụ. Site na nghọta ndị mmadụ banyere capsules osisi na mgbanwe nke echiche ọgwụ ọha na eze n'ụlọ na mba ọzọ, ahịa ahịa maka capsules osisi ga-eto ngwa ngwa.

Nke ise bụ dị ka onye na-akwụsịtụ. Nkwusioru-ụdị mmiri mmiri nkwadebe bụ a na-ejikarị Clinical onunu ogwu ụdị, nke bụ a heterogeneous dispersion usoro nke insoluble siri ike ọgwụ na-agbasasị na a mmiri mmiri dispersion usoro. Nkwụsi ike nke usoro ahụ na-ekpebi ịdị mma nke nkwadebe mmiri nkwusioru. HPMC colloidal ngwọta nwere ike ibelata siri ike-mmiri mmiri interfacial esemokwu, belata n'elu free ike nke siri ike ahụ, na kwụsie ike na heterogeneous dispersion usoro. Ọ bụ ezigbo onye nkwusioru. A na-eji HPMC eme ihe dị ka ihe na-ekpu mmiri maka ọdịda anya, yana ọdịnaya nke 0.45% ruo 1.0%.

Hydroxypropyl cellulose:

Hydroxypropyl cellulose (HPC) bụ otu ether na-abụghị ionic cellulose nke sitere na owu na osisi site na alkalization na propylene oxide etherification. HPC na-abụkarị soluble na mmiri n'okpuru 40 Celsius C na ọnụ ọgụgụ buru ibu nke ihe mgbaze pola, na arụmọrụ ya metụtara ọdịnaya nke otu hydroxypropyl na ogo nke polymerization. HPC nwere ike dakọtara na ọgwụ dị iche iche ma nwee ezigbo inertia.

A na-ejikarị hydroxypropyl cellulose (L-HPC) nọchiri anya ala dị ka mbadamba mbadamba na ihe nkedo. -HPC nwere ike imeziwanye ike na nchapụta nke mbadamba nkume ahụ, ma nwee ike ime ka mbadamba nkume ahụ gbasasịa ngwa ngwa, melite ogo dị n'ime mbadamba nkume ahụ, ma melite mmetụta ọgwụgwọ.

Enwere ike iji hydroxypropyl cellulose dochie anya nke ukwuu (H-HPC) dị ka ihe nkpuchi maka mbadamba nkume, granules, na granules dị mma na mpaghara ọgwụ. H-HPC nwere ezigbo ihe na-emepụta ihe nkiri, ihe nkiri a nwetara bụ ihe siri ike na nke na-agbanwe, nke enwere ike iji ya tụnyere plastik. Enwere ike imeziwanye arụmọrụ nke ihe nkiri ahụ site na ịgwakọta ihe ndị ọzọ na-ekpuchi mmiri na-eguzogide mmiri, a na-ejikarị ya eme ihe dị ka ihe mkpuchi ihe nkiri maka mbadamba nkume. H-HPC nwekwara ike iji dị ka ihe matriks iji kwadebe mbadamba ihe ntọhapụ matriks, pellet akwadoro na mbadamba ihe ntọhapụ nke okpukpu abụọ.

Hydroxyethyl cellulose

Hydroxyethyl cellulose (HEC) bụ otu ether cellulose na-abụghị ionic nke sitere na owu na osisi site na alkalization na etherification nke ethylene oxide. N'ihe gbasara ọgwụ, a na-ejikarị HEC eme ihe dị ka onye na-agba ume, onye na-ahụ maka nchebe colloidal, nrapado, dispersant, stabilizer, onye na-akwụsị akwụsị, onye na-emepụta ihe nkiri na ihe na-ahapụ ya, a pụkwara itinye ya na emulsions n'elu, ointments, anya mmiri. Mmiri ọnụ, mbadamba nkume siri ike, capsule na ụdị usoro onunu ogwu ndị ọzọ. Edekọla hydroxyethyl cellulose na US Pharmacopoeia/US National Formulary na European Pharmacopoeia.

Ethyl cellulose:

Ethyl cellulose (EC) bụ otu n'ime ihe ndị a na-ejikarị eme ihe na mmiri na-adịghị edozi. EC abụghị ihe na-egbu egbu, kwụsiri ike, nke a na-esighị ike na mmiri, acid ma ọ bụ alkali, yana soluble na ihe mgbaze organic dị ka ethanol na methanol. Ihe mgbaze a na-ejikarị bụ toluene/ethanol dị ka 4/1 (arọ) ihe mgbaze agwakọta. EC nwere otutu ojiji na nkwadebe ntọhapụ ọgwụ, nke a na-ejikarị dị ka ndị na-ebu, microcapsules, na mkpuchi ihe na-emepụta ihe nkiri maka nkwadebe ntọhapụ, dị ka mbadamba ihe mgbochi, adhesives na ihe mkpuchi ihe nkiri, eji dị ka ihe nkiri ihe nkiri matrix iji kwadebe. ụdị dị iche iche nke matriks kwadoro-mwepụta mbadamba, eji dị ka ihe agwakọta ihe iji kwadebe mkpuchi na-adịgide adịgide-nkwadebe, pellets na-adịgide adịgide, na-eji dị ka encapsulation ihe inyeaka iji kwadebe microcapsules na-adịgide adịgide; a pụkwara iji ya mee ihe n'ọtụtụ ebe dị ka ihe na-ebu ibu Maka nkwadebe nke mgbasa siri ike; A na-ejikarị ya na nkà na ụzụ ọgwụ dị ka ihe na-emepụta ihe nkiri na mkpuchi nchebe, yana nkedo na ihe nkpuchi. Dị ka mkpuchi mkpuchi nke mbadamba nkume ahụ, ọ nwere ike belata mmetụta nke mbadamba nkume na iru mmiri ma gbochie ọgwụ ahụ ka ọ ghara imetụta mmiri mmiri, ngbanwe na mmebi; ọ nwekwara ike ịmepụta akwa gel na-ahapụ ngwa ngwa, microencapsulate polymer, ma mee ka ntọhapụ nke ọgwụ ahụ na-adịgide adịgide.