Hydroxypropylmethylcellulose (HPMC) bụ polymer vasatail eji n'ọtụtụ ụlọ ọrụ, gụnyere ọgwụ, ihe owuwu, nri, na ihe ịchọ mma. Otu n'ime ngwa ya a na-ahụkarị bụ n'ichepụta ngwaahịa gel. Gel bụ sistemu semisolid nwere njirimara rheological pụrụ iche, yana ihe dị iche iche nwere ike imetụta arụmọrụ ha, gụnyere okpomọkụ.
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Hydroxypropylmethylcellulose (HPMC) bụ ihe nrụpụta cellulose emepụtara site n'ịgwọ cellulose na propylene oxide na methyl chloride. Ọ bụ nke cellulose ether ezinụlọ ma nwee mmiri-soluble na gelling Njirimara. A na-eji HPMC n'ọtụtụ ebe na ụlọ ọrụ ọgwụ, nri, ihe owuwu na ụlọ ọrụ ịchọ mma n'ihi ike imepụta fim, ịgbanye na gelling.
Ọnụ ego nke HPMC
Gelation bụ usoro nke mmiri mmiri ma ọ bụ sol na-agbanwe n'ime gel, steeti siri ike nke nwere ma mmiri mmiri na ihe siri ike. HPMC gels site na usoro hydration na nhazi netwọk akụkụ atọ. Usoro gelation na-emetụta ihe ndị dị ka nchịkọta polymer, ịdị arọ molecular na okpomọkụ.
Ndabere okpomọkụ nke gelation
Okpomọkụ na-arụ ọrụ dị mkpa na omume gelation nke HPMC. Mmekọrịta dị n'etiti okpomọkụ na gelation nwere ike ịdị mgbagwoju anya, ọ dịkwa oke mkpa ịghọta otú mgbanwe okpomọkụ si emetụta njirimara nke gels HPMC. N'ikwu okwu n'ozuzu, gelation nke HPMC bụ usoro exothermic, nke pụtara na ọ na-ewepụta okpomọkụ.
1. Nchịkọta nke thermal gels
Thermal gelation curves nke HPMC na-eji Gelation okpomọkụ nso, ntụgharị okpomọkụ nso ebe mgbanwe si sol na gel na-eme. A na-emetụta okpomọkụ gelation site na ntinye uche HPMC na ngwọta. Ọnụ ọgụgụ dị elu na-ebutekarị okpomọkụ gelling dị elu.
2. Mmetụta na viscosity
Okpomọkụ na-emetụta viscosity nke ngwọta HPMC ma si otú ahụ usoro gelation. Ka okpomọkụ na-abawanye, viscosity nke ngwọta HPMC na-ebelata. Mbelata nke viscosity na-emetụta ike ike gel na njirimara gel ikpeazụ. A ghaghị iji nlezianya chịkwaa ma nyochaa okpomọkụ n'oge nhazi iji nweta viscosity na gel Njirimara.
Ihe na-emetụta okpomọkụ gel
Ọtụtụ ihe na-emetụta okpomọkụ gel nke HPMC, na ịghọta ihe ndị a dị oke mkpa maka ndị na-emepụta ihe na ndị nchọpụta.
1. Polymer ntinye uche
Ntinye nke HPMC na usoro bụ isi ihe na-emetụta okpomọkụ gelation. Ọnụ ọgụgụ dị elu na-ebutekarị okpomọkụ gelation dị elu. A na-ekwu na mmekọrịta a n'ihi mmụba nke ụdọ polymer dị maka mmekọrịta intermolecular, na-ebute netwọk gel siri ike.
2. Molecular arọ nke HPMC
The molekụla arọ nke HPMC na-emetụtakwa gelation. HPMC dị elu dị elu nwere ike igosipụta okpomoku jel dị iche iche ma e jiri ya tụnyere HPMC dị arọ molekul. Ibu arọ nke molecular na-emetụta solubility nke polymer, ntinye yinye, na ike nke netwọk gel guzobere.
3. Ọnụọgụ hydration
Ọnọdụ okpomọkụ na-emetụta ọnụego hydration HPMC. Okpomọkụ dị elu na-eme ka usoro hydration dị ngwa, na-eme ka gelation ngwa ngwa. Nke a dị mkpa karịsịa maka usoro nhazi oge nke chọrọ gelation ngwa ngwa.
4. Ọnụnọ nke mgbakwunye
Ọnụnọ nke ihe mgbakwunye dị ka plasticizers ma ọ bụ nnu nwere ike gbanwee okpomọkụ gelling nke HPMC. Ihe mgbakwunye ndị a nwere ike iji ụdọ polymer na-emekọrịta ihe, na-emetụta ikike ha imepụta netwọkụ gel. Ndị na-emepụta ihe ga-eji nlezianya tụlee mmetụta nke mgbakwunye na omume gel.
Ihe bara uru na ngwa
Ịghọta omume gel na-adabere na okpomọkụ nke HPMC dị oke mkpa maka ịmepụta ngwaahịa nwere àgwà na arụmọrụ na-agbanwe agbanwe. Nghọta a na-ewepụta ọtụtụ ihe bara uru na ngwa.
1. Ọgwụ ntọhapụ na-achịkwa
N'ime ụlọ ọrụ na-emepụta ọgwụ, a na-ejikarị HPMC eme ihe n'ụdị ọgwụ eji ejikwa ya. Enwere ike iji mmetụta okpomọkụ nke gels HPMC jikwaa ntọhapụ nke ọgwụ na-arụ ọrụ. Site na iji nlezianya dozie okpomọkụ gelation, ndị na-emepụta ihe nwere ike ịhazi profaịlụ ntọhapụ ọgwụ.
2. Hydrogels na-anabata okpomọkụ
Mmetụta okpomọkụ nke HPMC na-eme ka ọ dị mma maka mmepe nke hydrogels na-anabata okpomọkụ. Ndị hydrogels ndị a nwere ike ịme mgbanwe mgbanwe sol-gel na-agbanwe agbanwe na nzaghachi mgbanwe okpomọkụ, na-eme ka ha baa uru maka ngwa dị ka ọgwụgwọ ọnya na nnyefe ọgwụ.
3. Ihe owuwu ụlọ
N'ime ụlọ ọrụ ihe owuwu, a na-ejikarị HPMC eme ihe dị ka ihe mgbakwunye na ihe ndị sitere na ciment iji meziwanye ọrụ na njide mmiri. Mmetụta okpomọkụ nke HPMC na-emetụta oge nhazi na njirimara rheological nke ihe ndị a, si otú ahụ na-emetụta arụmọrụ ha n'oge ewu.
Ihe ịma aka na ngwọta
Ọ bụ ezie na omume gel dabere na okpomọkụ nke HPMC na-enye uru pụrụ iche, ọ na-ebutekwa ihe ịma aka na ụfọdụ ngwa. Dịka ọmụmaatụ, ịnweta ihe gel na-agbanwe agbanwe nwere ike bụrụ ihe ịma aka na nhazi ebe mgbanwe okpomọkụ na-emekarị. Ndị na-emepụta ihe ga-atụle ihe ịma aka ndị a ma tinye usoro iji dozie ha.
1. Njikwa okpomọkụ n'oge nkwadebe
Iji hụ na arụ ọrụ gel nwere ike imepụtaghachi, njikwa okpomọkụ siri ike n'oge nhazi dị oke mkpa. Nke a nwere ike ịgụnye iji ngwa agwakọta okpomọkụ na-achịkwa yana nyochaa ọnọdụ okpomọkụ n'oge nhazi ahụ.
2. Nhọrọ polymer
Ọ dị oke mkpa ịhọrọ ọkwa kwesịrị ekwesị nke HPMC nwere njirimara okpomọkụ gel chọrọ. Ọkwa dị iche iche nke HPMC dị na nha molekụla dị iche iche na ọkwa nnọchi, na-enye ndị na-emepụta ohere ịhọrọ polymer kacha dabara adaba maka ngwa ha akọwapụtara.
3. Nkwalite ọzọ
Ọnụnọ nke ihe mgbakwunye na-emetụta okpomọkụ gelling nke HPMC. Onye na-emepụta ihe nwere ike ịdị mkpa ịkwalite ụdị na itinye uche nke ihe mgbakwunye iji nweta njirimara gel chọrọ. Nke a na-achọ usoro nhazi yana nghọta nke ọma gbasara mmekọrịta dị n'etiti HPMC na mgbakwunye.
Hydroxypropylmethylcellulose (HPMC) bụ polymer multifunctional nwere ihe gel pụrụ iche nke okpomọkụ na-emetụta. Gelation na-adabere na okpomọkụ nke HPMC nwere mmetụta dị ịrịba ama maka ọtụtụ ụlọ ọrụ gụnyere ọgwụ, ihe owuwu, na ihe ịchọ mma. Ịghọta ihe ndị na-emetụta okpomọkụ gelation, dị ka nchịkọta polymer, ịdị arọ molecular, na ọnụnọ nke ihe mgbakwunye, dị oké mkpa nye ndị na-emepụta ihe na-achọ ịkwalite arụmọrụ gel maka ngwa ngwa.
Ka nkà na ụzụ na-aga n'ihu na nchọpụta sayensị polymer na-aga n'ihu, nghọta ọzọ nke omume dabere na okpomọkụ nke HPMC nwere ike iduga n'ịzụlite usoro na ngwa ọhụrụ. Ikike ịmegharị ihe ndị dị mma nke gel na-emepe ohere ọhụrụ maka ịmepụta ihe ndị nwere ahaziri iche, na-enyere aka n'ọganihu na nnyefe ọgwụ, biomaterials na ubi ndị ọzọ.
Oge nzipu: Jan-11-2024