Hydroxypropyl Methyl Cellulose HPMC

Hydroxypropyl methylcellulose(HPMC) bụ ihe nrụpụta cellulose nke a na-ejikarị na ụlọ ọrụ dị iche iche, gụnyere ọgwụ, nri, ihe owuwu, na nlekọta onwe onye. A na-eme ya site n'ịgbanwe cellulose nke ọma site na etherification, nke gụnyere iwebata hydroxypropyl na methyl n'ime molekul cellulose.

HPMC bụ ntụ ntụ na-enweghị isi na-acha ọcha ma na-acha ọcha nke na-agbaze n'ime mmiri wee mepụta ngwọta doro anya, viscous. Ọ nwere ihe dị iche iche na-eme ka ọ baa uru na ngwa dị iche iche. Dị ka ọmụmaatụ, ọ bụ thickener, stabilizer, na emulsifier na ngwaahịa nri. N'ime ihe owuwu, a na-eji ya dị ka ihe na-ejigide mmiri na ciment na ngwa agha iji meziwanye ọrụ na igbochi mgbawa. N'ime ngwaahịa nlekọta onwe onye, ​​a na-eji ya dị ka ihe na-esi ísì ụtọ na emulsifier na lotions, creams, na ngwaahịa ndị ọzọ.

N'ọgwụ ọgwụ, a na-eji HPMC dị ka ihe nchikota, nke na-agbasa, na onye na-ewepụta njikwa na mbadamba na capsules. A na-ejikwa ya dị ka onye na-akwụsịtụ n'ụdị mmiri mmiri yana dị ka ihe na-esi ísì ụtọ na ointments na creams. HPMC bụ ihe anabatara nke ọma na ụlọ ọrụ ọgwụ n'ihi ndakọrịta ya, nchekwa na nsi dị ala.

HPMC nwere ọtụtụ akara ule nwere ọkwa viscosity dị iche iche, nke ejiri koodu ọnụọgụ họpụta. Ọnụ ọgụgụ dị elu, ka viscosity dị elu. Akara ule HPMC sitere na viscosity dị ala (5 cps) ruo nnukwu viscosity (100,000 cps). Viscosity nke HPMC bụ ihe dị oke mkpa n'ịchọpụta akụrụngwa na ngwa ya.

Ojiji nke HPMC n'ime ọgwụ na-eto eto n'afọ ndị na-adịbeghị anya n'ihi njirimara ya dị iche iche yana mmụba na-achọ usoro nnyefe ọgwụ ọhụrụ. Ejirila hydrogels sitere na HPMC na sistemu nnyefe ọgwụ n'ihi ndakọrịta ha, ntọhapụ a na-achịkwa, yana akụrụngwa mucoadhesive. E mepụtakwara mbadamba nkume HPMC nwere njirimara ewepụtara emezigharị nke na-enye ohere maka nnyefe ọgwụ ezubere iche yana kwalite nnabata onye ọrịa.

Agbanyeghị, HPMC enweghị oke ya. Ọ nwere adịghị ike solubility na organic solvents na-enwe mmetụta nke pH mgbanwe. Na mgbakwunye, ọ nwere oke okpomọkụ dị oke ma nwee ike hapụ viscosity ya na oke okpomọkụ. Ihe mgbochi ndị a emeela ka mmepe nke ihe ndị ọzọ na-emepụta cellulose, dị ka hydroxyethyl cellulose (HEC) na carboxymethyl cellulose (CMC), bụ ndị nweworo ihe onwunwe dị mma na ngwa ngwa ngwa ngwa.

N'ikpeazụ, HPMC bụ ihe nrụpụta cellulose dị iche iche nke a na-ejikarị eme ihe na ụlọ ọrụ dị iche iche, karịsịa na ọgwụ. Ngwongwo ya pụrụ iche, gụnyere bioocompatibility ya, nchekwa ya na nsi dị ala, na-eme ka ọ bụrụ ihe na-ewu ewu na nhazi ọgwụ. Sistemụ nnyefe ọgwụ dabere na HPMC egosila nkwa iji melite nrụpụta ọgwụ na nnabata ndị ọrịa. Otú ọ dị, njedebe ya na solubility na pH sensitivity emeela ka mmepụta nke cellulose ndị ọzọ na-emepụta ihe na-eme ka ọ dịkwuo mma.