Lekwasị anya na cellulose ethers

HPMC na-eji na mbadamba mkpuchi

HPMC na-eji mkpuchi mbadamba mbadamba

mbadamba ihe mkpuchi a na-ejikarị eme ihe n'ụdị nkwadebe siri ike, dị ka nkembadamba ihe mkpuchi enwere ike kewaa ihe n'ime ntụ ntụmbadamba ihe mkpuchi, pelletmbadamba ihe mkpuchi, urughurumbadamba ihe mkpuchi, mbadamba nkumembadamba ihe mkpuchi, Capsulembadamba ihe mkpuchi; Dabere nambadamba ihe mkpuchi ihe na-ekewa n'ime shugambadamba ihe mkpuchi, ọkara ihe nkirimbadamba ihe mkpuchi, ihe nkirimbadamba ihe mkpuchi (dabere na ihe dị iche iche nke polymer, gụnyere entericmbadamba ihe mkpuchi), ihe pụrụ ichembadamba ihe mkpuchi (dị ka stearic acid, paraffin, polysaccharide); Dabere nambadamba ihe mkpuchi teknụzụ, ọ nwere ike kewaa n'ime ịgbambadamba ihe mkpuchi, tinyembadamba ihe mkpuchi, nrụgide akọrọmbadamba ihe mkpuchi, electrostaticmbadamba ihe mkpuchi na laminatingmbadamba ihe mkpuchi. N'ime ha, ịgbambadamba ihe mkpuchi bụ ihe kacha eji eme ihe. Ụkpụrụ ya bụ ịgbambadamba ihe mkpuchi mmiri mmiri n'ime alụlụ ụmụ irighiri mmiri na-ekpuchi elu ihe (ntụ ntụ, ahụ, mbadamba). Na ngwa ngwa akọrọ na-etolitembadamba ihe mkpuchi oyi akwa: dị kambadamba ihe mkpuchi nzube na-ekewa n'ime mmiri solublembadamba ihe mkpuchi, afọ sochirimbadamba ihe mkpuchi, enweghị mgbazembadamba ihe mkpuchi, ntọhapụ nwayọmbadamba ihe mkpuchi, ihe mgbumbadamba ihe mkpuchi.

 

Ọrụ nkembadamba ihe mkpuchi na-agụnye: (1) mgbochi mmiri, ọkụ, ikuku dịpụrụ adịpụ iji mee ka nkwụsi ike ọgwụ ike; (2) Na-ekpuchi isi ísì ọjọọ, belata mkpali; (3) Meziwanye ọdịdị ahụ, dị mfe ịmata; (4) Jikwaa ebe ntọhapụ ọgwụ, dị ka na gastric ihe ọṅụṅụ dị mfe ibibi nke mere na ọ na-ẹkenịmde ke eriri afọ: (5) ịchịkwa ọgwụ dispersion, tọhapụ ọsọ: (6) imeri incompatibility, wdg The.mbadamba ihe mkpuchi ihe kwesịrị inwe ihe ndị a chọrọ: adịghị egbu egbu, enweghị inertia kemịkalụ, kwụsiri ike na okpomọkụ, ọkụ, mmiri, ikuku, na anaghị emeghachi omume nambadamba ihe mkpuchi ọgwụ ọjọọ; (2) nwere ike etisasịwo n'ime evenly agbasasị ke dispersion ọkara kwesịrị ekwesị makambadamba ihe mkpuchi: (3) nwere ike ịmepụta oyi akwa na-aga n'ihu, nke siri ike, dị nro, nkwụsị mgbape ma nwee ezigbo mmiri dịpụrụ adịpụ, nkewa mmiri, shading, ikuku permeability;Ya solubility kwesịrị izute chọrọ nke - ofu, mgbe ụfọdụ ọ dịghị mkpa ka PH emetụta, mgbe ụfọdụ nwere ike igbari na a kpọmkwem PH nso. Ụdị ihe nke nwere n'elu njirimara n'otu oge ahụ adịghị ahụ nke ukwuu, ihe kpatara ya na-ejikarị agwakọtambadamba ihe mkpuchi ihe onwunwe ọzọ, iji mụta ihe n'aka ibe ya.

 

Mbadamba ụrọmbadamba ihe mkpuchi bụ nke a na-ejikarị eme ihe, ọ na-ejikarị itembadamba ihe mkpuchi na ọkpọkọ lirimbadamba ihe mkpuchi (oke arụmọrụmbadamba ihe mkpuchi igwembadamba ihe mkpuchi), nke ikpeazụ dị mma maka ihe nkirimbadamba ihe mkpuchi. Ihe ndina nwere mmiri mmirimbadamba ihe mkpuchi dabara adaba maka ihe nwere obere urughuru nha dị ka pellets na ntụ ntụ. Tụnyere shugambadamba ihe mkpuchi, ihe nkirimbadamba ihe mkpuchi nwere ọtụtụ uru:( 1) Mee ka oge dị mkpirikpi ma belata ọnụ ahịa ihe onwunwe; (2) enweghị mmụba dị ịrịba ama na ịdị arọ: (3) ọ dịghị mkpa maka oyi akwa ala: (4) ike, nkwụsịtụ na mgbawa: (5) nwere ike ibipụta ya, ọ dịghịkwa emetụta mkpụrụedemede mgbawa;6) Nwere ike chebe ngwaahịa ahụ nke ọma site na mmetụta nke ìhè, ikuku na mmiri; (7) Enweghị mmetụta ọjọọ na oge nkwụsịtụ:( 8) ngwaahịa mma:( 9) na-enye ohere iji na-abụghị mmirimbadamba ihe mkpuchi; Enwere ike ịhazi usoro na ihe. Ugbu a mmepe nke ngwaahịa ọhụrụmbadamba ihe mkpuchi nkwadebe n'ozuzu nakweere ihe nkirimbadamba ihe mkpuchi, ihe nkirimbadamba ihe mkpuchi Ihe mejupụtara ndenye ọgwụ gụnyere onye na-emepụta ihe nkiri (mbadamba ihe mkpuchi ihe), ihe mgbaze, plasticizer, colorant, nwekwara ike ịgbakwunye pore-akpata gị n'ụlọnga, insoluble filler, wdg .. The mejupụtara nke filmmbadamba ihe mkpuchi ndenye ọgwụ bụ isi ihe ịga nke ọma nkembadamba ihe mkpuchi. Ka ọ dị ugbu a, ihe nkiri na-edozi mmirimbadamba ihe mkpuchi Ihe ndị a na-ejikarị gụnyere hydroxypropyl methyl cellulose (HPMC) na hydroxypropyl cellulose (HPC). Polyethylene glycol (PEG), polyethylene pyrrolidone (PVP), ihe ndị nwere ike ime ka ọ bụrụ ihe na-edozi ahụ gụnyere resin enteric-soluble acrylic resin, hydroxypropyl methyl cellulose phthalate (HPMCP). Cellulose acetate phthalate ester (CAP). Shellac, ihe ndị na-adịghị edozi ahụ gụnyere ethyl cellulose (EC), zein.

Kemgbe ọtụtụ afọ, ihe nkirimbadamba ihe mkpuchi enweela ọganihu dị ịrịba ama. Ụkpụrụ ọdịnalambadamba ihe mkpuchi usoro ejiHPMC(hydroxypropyl methylcellulose) dị ka isi polymer, nke a ka na-ejikarị eme ihe taa. HPMC-daberembadamba ihe mkpuchi Sistemu na-enye arụmọrụ zuru oke, mana a ka nwere ohere maka mmelite. HPMCmbadamba ihe mkpuchi ihe nkiri nwere ike ọ gaghị adabara na mbadamba nkume nke ọma, na-adịkarị ogologombadamba ihe mkpuchi oge, na-ebute mmepụta ngwa ngwa. Udi mmeghe nkedabere na PVA mbadamba ihe mkpuchi Sistemu emela ka arụ ọrụ ka mma, na-eme ka ọ dị mmambadamba ihe mkpuchi arụmọrụ na mmepụta ngwa ngwa mmepụta ngwa ngwa, nke pụtara na ntụpọ adịghị adịkarị na mbadamba nkume.

Dị ka viscosity nke HPMC na-abawanye, ike nke ihe nkiri guzobere HPMC na-abawanye kwekọrọ ekwekọ, na n'ikpeazụ rute kacha film ike agaghịkwa na-abawanye na-abawanye nke viscosity nke HPMC.

N'imembadamba ihe mkpuchi, iji nweta ihe kacha arụ ọrụ nke ọmambadamba ihe mkpuchi, na-emekarị ka mmambadamba ihe mkpuchi mmiri mmiri siri ike ọdịnaya, nke ga-eduga nambadamba ihe mkpuchi mmiri mmiri viscosity bụ oke elu, họrọ ala viscosity HPMC nwere ike n'ụzọ dị irè dozie nsogbu a, ma na-eduga film ike na-emetụta. Iji dozie nsogbu ejima ndị a, ịgwakọta polymers aghọwo ngwá ọrụ nkịtị.

Dị kaHPMCE15 ọdịnaya nke nta nke nta na-abawanye, na viscosity nke ngwakọta nkeHPMCE5 naHPMCE15 na-abawanye nke nta nke nta.

 

Na shugambadamba ihe mkpuchi, anyị esiwokwa na nka gaa na sayensị. Ngwaahịa ndị e kpuchiri shuga na-atọ ụtọ nke ukwuu n'ihi na ha nwere ọmarịcha, na-egbukepụ egbukepụ, na-atọ ụtọ nke na-ekpuchi uto ilu. Mana nnukwu nsogbu na shugambadamba ihe mkpuchi dina na arụpụtaghị ihe na reproducibility. Sugarmbadamba ihe mkpuchi bụ usoro ntuziaka na-arụsi ọrụ ike ma na-ewe oge ma nwee ike ịdịgasị iche site na ogbe ruo n'ọkwa dabere na onye na-eme ya.mbadamba ihe mkpuchi.


Oge nzipu: Dec-23-2023
Mkparịta ụka WhatsApp n'ịntanetị!