Focus on Cellulose ethers

A na-eji HPMC eme ihe n'ịtụ anya

A na-eji HPMC eme ihe n'ịtụ anya

Hydroxypropyl methylcellulose (HPMC) bụ polymer a na-ejikarị eme ihe na ụlọ ọrụ na-emepụta ọgwụ, karịsịa na mmepe nke usoro ọgwụ anya dị ka nsị anya. A na-eji mmiri ntanye anya na-agwọ ọnọdụ dị iche iche dị ka anya nkụ, glaucoma, na allergies. Enwere ike iji HPMC mee ihe na anya mmiri dị ka ihe na-eme ka viscosity dịkwuo mma, onye na-ahụ maka mucoadhesive, na ihe nchebe. N'isiokwu a, anyị ga-enyocha ojiji nke HPMC na anya tụlee n'ụzọ zuru ezu.

Ihe na-akwalite viscosity

Otu n'ime isi ọrụ nke HPMC na anya tụlee bụ ịkwalite viscosity ha. Viscosity bụ ihe dị mkpa n'ime usoro ọgwụgwọ anya dịka ọ na-enyere aka hụ na nhazi ahụ na-anọ n'elu anya ogologo oge iji nye uru ọgwụgwọ. The viscosity nke HPMC ngwọta na-adabere na molekụla arọ nke polima na ogo nke nnọchi. Ihe ngwọta HPMC nwere ịdị arọ molekụla dị elu yana ogo nnọchi nwere viscosity dị elu.

HPMC bụ ezigbo viscosity enhancer maka anya tụlee ka ọ na-enye a na-adịgide adịgide-mwepu mmetụta n'ihi ya gel-akpụ Njirimara. Gel nke HPMC mebere n'ime anya anya na-agbatị oge kọntaktị n'etiti ọgwụ na anya, si otú a na-eme ka ọ dị mma nke ọgwụ. Ọzọkwa, ihe ngwọta HPMC adịghị eme ka ọhụụ ghara ime ka ọ bụrụ ihe dị mma maka ọdịda anya.

Onye na-ahụ maka mucoadhesive

Ọrụ ọzọ dị ịrịba ama nke HPMC na anya tụlee bụ mucoadhesive Njirimara. HPMC nwere mmekọrịta dị elu maka akpụkpọ anụ imi, na iji ya mee ihe na anya mmiri nwere ike inye aka ịgbatị oge obibi nke nhazi ahụ n'elu anya. Nke a bara uru karịsịa n'ịgwọ ọrịa ọrịa anya akọrọ, ebe ogologo oge na-egosi na nhazi ahụ nwere ike inye aka belata mgbaàmà nke nkụ na ahụ erughị ala.

Njirimara mucoadhesive nke HPMC bụ n'ihi mmekọrịta ya na njikọta hydrogen na mucin glycoproteins. Mucin glycoproteins bụ isi ihe dị na oyi akwa mkpuchi elu nke anya, nke na-eje ozi dị ka ihe mgbochi nchebe. HPMC nwere ike ịrapara n'ahụ oyi akwa ma gbasaa oge kọntaktị nke nhazi ahụ n'elu anya.

Onye nnọchi anya nchebe

Na mgbakwunye na ihe na-eme ka viscosity na mucoadhesive Njirimara, a na-ejikwa HPMC dị ka ihe nchebe na nsị anya. Elu anya na-enwe ike imebi site na ihe ndị dị na mpụga dịka UV radieshon, mmetọ, na ikuku kpọrọ nkụ. HPMC nwere ike ịmepụta ihe nkiri nchebe n'elu elu anya nke nwere ike inye aka chebe anya site na ihe ndị a na-emerụ ahụ.

Ihe nchebe nke HPMC bụ n'ihi nhazi nke gel-dị ka oyi akwa n'elu anya. Igwe oyi akwa a na-arụ ọrụ dị ka ihe mgbochi anụ ahụ nke nwere ike inye aka gbochie ntinye nke ndị na-emerụ ahụ n'ime anya. HPMC nwekwara ike inye aka mee ka ihu ahụ dị jụụ ma belata ihe mgbaàmà nke mgbakasị anya.

Mmechi

N'ikpeazụ, HPMC bụ polymer dị iche iche nke na-achọta ọtụtụ ojiji na mmepe nke usoro ọgwụ anya, karịsịa anya mmiri. HPMC nwere ike melite viscosity nke anya tụlee, nke nwere ike inye aka ogologo oge ha na kọntaktị n'elu anya ma melite arụmọrụ ha. Njirimara mucoadhesive nke HPMC nwere ike inye aka ịgbatị oge obibi nke nhazi ahụ n'elu ihu anya, na-eme ka ọ bụrụ nhọrọ dị mma maka ọgwụgwọ ọrịa anya nkụ. HPMC nwekwara ike ichebe elu anya site na ihe ndị dịpụrụ adịpụ na-emerụ ahụ site n'ịme akwa mkpuchi. Nhọpụta nke ọma nke ọkwa HPMC kwesịrị ekwesị na itinye uche nwere ike inye aka hụ na arụmọrụ kacha mma yana ndakọrịta na usoro ntinye anya.


Oge nzipu: Feb-13-2023
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