Hydroxypropyl methylcellulose (HPMC) bụ ihe dị mkpa polymer, nke a na-ejikarị eme ihe n'ígwé nke putty n'ọhịa ihe owuwu. Ọ nwere ike imeziwanye arụmọrụ ihe owuwu na mma nke putty. Ọ nwere ike ọ bụghị nanị na-emeziwanye arụmọrụ ihe owuwu nke putty, kamakwa welie adhesion ya, njigide mmiri na nkwụsị mgbape, n'ihi ya, a na-akwanyere ya ùgwù nke ukwuu na-ewu ụlọ.
1. Basic e ji mara HPMC
HPMC bụ ether cellulose na-abụghị ionic, nke ejiri kemịkal gbanwee site na cellulose eke. Ya aqueous ngwọta nwere ezigbo mmiri njigide, ndim na nrapado, na ike n'ọtụtụ ebe na-emegharị ka dị iche iche ngwa mkpa na-ewu gburugburu ebe obibi. Mgbe agbazere HPMC n'ime mmiri, ọ nwere ike ịmepụta ngwọta colloidal na-enweghị atụ ma kwụsie ike, nke uru pH adịghị emetụta ngwa ngwa. Na mgbakwunye, ọ nwekwara ike iguzogide enzymatic hydrolysis, ọxịdashọn-eguzogide, ìhè eguzogide, acid eguzogide, alkali iguzogide na ndị ọzọ e ji mara, nke na-enyere HPMC aka ịnọgide na-enwe ezi arụmọrụ dị iche iche ewu gburugburu.
2. Ụkpụrụ ọrụ nke HPMC na oyi akwa putty
Na oyi akwa putty, HPMC na-arụ ọrụ ndị a:
Mee ka njide mmiri dịkwuo elu: HPMC nwere ikike njigide mmiri siri ike, nke nwere ike igbochi mmiri dị na oyi akwa putty ka ọ ghara ikpochapụ ngwa ngwa. N'oge usoro ihe owuwu nke putty, elu ga-eme ngwa ngwa ihicha n'ihi mmiri evaporation, ma ọnụnọ nke HPMC nwere ike na-etinye oyi akwa oyi akwa na nnukwu mmiri ọdịnaya, si otú ịgbatị oge na-emeghe nke putty, nke na-eme ka ndị na-arụ ọrụ na-arụ ọrụ gbanwee. ma gbanwee, ma na-enyekwara putty aka ịkwado nke ọma ma zere mgbawa nke ihicha ngwa ngwa kpatara.
Meziwanye mkpụkọ: HPMC nwere mmetụta na-abawanye ụba, nke nwere ike inye putty slurry viscosity ka mma, si otú ahụ meziwanye arụmọrụ ngwa ya. Ngwunye putty na-achọ ụfọdụ viscosity iji kwado ihe owuwu, ebe ọ na-ahụ na etinyere putty nwere ike kesaa nke ọma ma jidesie mgbidi ahụ ike. Mmetụta siri ike nke HPMC nwere ike inyere oyi akwa putty aka ịnọgide na-enwe nkwụsi ike, na-eme ka ọrụ ahụ dịkwuo nro ma na-ebelata ihe ngosi nke sagging na slipping n'oge ewu.
Meziwanye mgbape mgbape: Nsogbu a na-ahụkarị na usoro ihicha nke oyi akwa putty bụ ọgbọ nke obere mgbawa, nke na-emetụta àgwà nke ngwaahịa emechara. HPMC nwere ike igbochi cracks na putty oyi akwa n'ihi na ọ nwere ike na-etolite a kwụsiri ike eriri netwọk Ọdịdị mgbe putty gwọrọ, si otú na-eme ka ike nke putty na ibelata cracking kpatara ihicha shrinkage na okpomọkụ nchegbu.
Melite arụmọrụ ihe owuwu: HPMC nwere ike imeziwanye ịdị mma nke ihe owuwu putty, na-eme ka ọ ghara inwe nsogbu dịka ọdụ ọdụ na akara mma n'oge usoro ihe owuwu. Ngwọta colloidal nke HPMC guzobere na mmiri nwere mmetụta mmanye mmanye dị mma, nke nwere ike ime ka putty dị nro mgbe ọ na-eme ka ọ dị nro ma na-egbuke egbuke, si otú ahụ na-ebelata ihe isi ike nke ihe owuwu.
Mee ka adhesion dịkwuo mma: HPMC nwere ike imeziwanye njikọ dị n'etiti oyi akwa putty na mgbidi dị n'okpuru, na-egbochi akwa putty ka ọ daa ma ọ bụ na-agbapụta. Ngwọta colloidal nke HPMC kpụrụ na putty nwere ike jikọta ya na ala ala iji mee ka ike ike nke putty dịkwuo elu. Nke a dị mma adhesion nwere ike hụ na oyi akwa putty na-anọgide na-adịgide adịgide ruo ogologo oge mgbe e wuchara ya, na-eme ka ịdịte aka nke mmetụta ịchọ mma n'ozuzu ya dịkwuo mma.
3. Uru na oke nke ngwa nke HPMC
Uru nke HPMC na ntinye nke putty layers na-egosipụtakarị n'akụkụ ndị a:
Meziwanye nrụpụta ihe owuwu nke putty: Ebe HPMC nwere ike ịgbatị oge oghe nke putty, ndị ọrụ na-ewu ụlọ nwere ike mezue ọrụ putty n'ọtụtụ oge, na-ebelata oge achọrọ maka ngwa ugboro ugboro, yana belata ihe isi ike nke ihe owuwu.
Chekwaa ihe eji eme ihe: Mmetụta na-agbapụta nke HPMC nwere ike ibelata ngbanwe mmiri, si otú ahụ na-amụba nkwụsi ike nke putty, na-eme ka putty dịkwuo ụba, na-ebelata ọnụ ọgụgụ nke putty, na ibelata ọnụ ahịa ihe owuwu.
Ọdabara dị iche iche nke mgbidi substrates: HPMC nwere ike ime mgbanwe nke ọma na a dịgasị iche iche nke substrates dị ka ihe mgbidi na ngwa agha bases, na ike n'ụzọ dị irè welie adhesion na ewu Njirimara maka dị iche iche mkpụrụ ụdị.
Mgbanwe siri ike na ihu igwe: Ebe ọ bụ na HPMC nwere njigide mmiri siri ike na nkwụsi ike, ọ bụrụgodị na a na-ewu ya na ebe dị ọkụ ma ọ bụ nke dị ala, ọ nwere ike igbochi ngwa ngwa mmiri na oyi akwa putty ma hụ na mmetụta dị mma nke putty.
IV. Akpachara anya maka ojiji nke HPMC
Na ngwa n'ezie, ego na usoro nke ịgbakwunye HPMC ga-emetụta arụmọrụ ikpeazụ nke putty. N'okpuru ọnọdụ nkịtị, ọnụọgụ HPMC agbakwunyere kwesịrị ịdị oke oke. Ọ bụrụ na agbakwunyere nke ukwuu, oge ihicha nke oyi akwa putty nwere ike ịdị ogologo, na-emetụta ọganihu ihe owuwu ahụ. Ya mere, mgbe ị na-eji ya, a ga-achịkwa ego ahụ nke ọma dịka njirimara nke ngwaahịa putty na gburugburu ebe obibi. Tụkwasị na nke ahụ, a ga-echekwa HPMC na ebe dị jụụ iji gbochie ya ịmịnye mmiri na agglomerating, nke ga-emetụta mmetụta eji eme ihe.
Ngwa nke HPMC na oyi akwa putty na-arụ ọrụ nke ọma, njide mmiri na nguzogide mgbape nke putty, na-enyere ya aka ịnọgide na-enwe nsonaazụ dị mma n'okpuru ọnọdụ ụlọ dị iche iche. Site n'ịgbakwụnye ihe kwesịrị ekwesị nke HPMC, onye na-emepụta ihe nwere ike ijikwa usoro ihe owuwu nke putty n'ụzọ dị mfe, melite elu elu nke oyi akwa putty na àgwà nke ngwaahịa emechara. Ya mere, ngwa nke HPMC na oyi akwa putty nwere ike ọ bụghị nanị na-eme ka mmetụta ahụ dịkwuo mma, kamakwa ịgbatị ndụ ọrụ nke oyi akwa a na-achọ mma, na-enye nkwa siri ike maka ọdịdị na mmetụta dị n'ime ụlọ ahụ.
Oge nzipu: Nov-02-2024