HPMC na Pharmaceuticals

The pharmaceutical excipient hydroxypropyl methyl cellulose (HPMC) bụ ihe na-abụghị ionic cellulose ether excipients, bụ ugbu a kasị n'ụlọ na mba ọzọ ojiji nke ọgwụ excipients - a, dị ka ọgwụ excipient nwere ihe karịrị 30 afọ nke akụkọ ihe mere eme. Ọ bụ odorless, keenweghiuto, na-adịghị egbu egbu, soluble na mmiri oyi, gelation na mmiri ọkụ, ala viscosity larịị HPMC nwere ike ji mee ihe dị ka nrapado, stickiness gị n'ụlọnga na nkwusioru gị n'ụlọnga elu viscosity larịị HPMC nwere ike iji kwadebe agwakọta ihe kpuchie kwadoro-ntọhapụ. Mbadamba ụrọ, capsules na-ahapụ nkwado, hydrophilic gel framework kwadoro-mwepu mbadamba ihe mgbochi, ihe ntọhapụ na-achịkwa na onye na-ahụ maka ọwa pore.

Ihe ndị na-emepụta ọgwụ na-ezo aka na ihe ndị na-emepụta ihe na ihe mgbakwunye na-eji na mmepụta na ikesa ọgwụ. Otu ihe, karịa ihe na-arụ ọrụ, nke enyochala nke ọma maka nchekwa ma tinye ya na ngwaahịa ọgwụ. Ihe ndị na-emepụta ọgwụ nwere ọrụ dị mkpa nke solubilizing, na-enyere aka mgbasa, ntọhapụ ngwa ngwa na njikwa na mgbakwunye na ịmepụta, na-ejuputa ndị na-ebu na imeziwanye nkwụsi ike, nke nwere ike imetụta àgwà, nchekwa na ịdị irè nke ọgwụ.

Hydroxypropyl methyl cellulose HPMC bụ otu n'ime ndị kasị ibu ọgwụ excipients n'ụlọ na ná mba ọzọ, nke e ji mee ihe dị ka ọgwụ excipients ruo ọtụtụ afọ. Ọ bụ ihe na-esi ísì ụtọ, enweghị ụtọ na nke na-adịghị egbu egbu, soluble na mmiri oyi na gelatinous na mmiri ọkụ. HPMC dị ka a eke hydrophilic polymer pharmaceutical ihe enyemaka, ọ bụghị nanị na a pụrụ iji dị ka mbadamba nkume, granule, pill nrapado na disintegrant, film mkpuchi ihe, nwekwara ike ga-eji dị ka a colloidal gị n'ụlọnga na nkwusioru gị n'ụlọnga, ngwa ngwa ntọhapụ na achịkwa ntọhapụ nkwadebe blocker, achịkwa. ihe ntọhapụ na onye na-eme pore, yana onye na-ebu mgbasa ozi siri ike.

HPMC dị ka onye na-ekekọta ihe na-emebi emebi. HPMC dị ka ihe nkedo nwere ike ibelata kọntaktị Angle ọgwụ, nke mere na ọgwụ ọjọọ dị mfe mmiri, na mmiri nke ya nwere ike gbasaa ọtụtụ narị ugboro, n'ihi ya, ọ pụrụ budata mma mgbasa ma ọ bụ ntọhapụ nke mbadamba. HPMC nwere ike viscosity, n'ihi na udidi nke crisp ma ọ bụ kenkuwa ike akụrụngwa nwere ike welie ya urughuru viscosity, melite ya compressibility. Enwere ike iji obere viscosity HPMC mee ihe dị ka onye na-ekekọta na nke na-agbasasị, nnukwu viscosity naanị dị ka onye na-ekekọta, ego dị iche iche dị ka ihe nlereanya na ihe a chọrọ, ọnụ ọgụgụ n'ozuzu bụ 2% -5%.

A na-eji HPMC dịka ihe ntọhapụ a na-achịkwa maka nkwadebe ọnụ. HPMC bụ ihe eji arụ ọrụ hydrogel nke a na-ejikarị na nkwado nkwado ntọhapụ. Enwere ike iji HPMC nwere ọkwa viscosity dị ala (5 ~ 50mPa •s) dị ka ihe nkedo, onye na-eme ka onye na-eme ka ọ dịkwuo mma na enyemaka nkwusioru, ebe enwere ike iji HPMC nwere ọkwa viscosity dị elu (4000 ~ 100000mPa • s) iji kwadebe ihe ejikọtara agwakọta ihe na-adịgide adịgide. Mbadamba ụrọ, capsules na-ahapụ ya, hydrophilic gel framework kwadoro-wepụta mbadamba nkume dị ka ihe mgbochi. HPMC nwere ike etisasịwo na gastric enteric fluid, nwere uru nke ezi pressability, ezi fluidity, ike ọgwụ loading ike na ọgwụ ntọhapụ àgwà na-adịghị emetụta pH, wdg, bụ ihe dị oké mkpa hydrophilic ụgbọelu ihe na nọgidere ntọhapụ nkwadebe usoro, ọtụtụ mgbe. eji dị ka hydrophilic gel framework na mkpuchi ihe nke nkwado ntọhapụ nọgidere na-adịgide adịgide, na-eji na gastric sere n'elu nkwadebe, kwadoro ntọhapụ ọgwụ ihe nkiri excipients.

HPMC dị ka mkpuchi ihe nkiri akpụ gị n'ụlọnga. HPMC nwere ezi film akpụ, ọ Nleta a transperent film, siri ike, mmepụta adịghị mfe ịrapara, karịsịa n'ihi na mfe mmiri absorption, ejighị n'aka ọgwụ ọjọọ, na ya dị ka ihe iche oyi akwa pụrụ nnọọ mma kwụsie ike nke ọgwụ ọjọọ, gbochie film discoloration. E jiri ya tụnyere nhazi ihe nkiri gelatin, ihe nkiri HPMC nwere ezigbo edo na nnyefe ọkụ. HPMC nwere nkọwa dị iche iche nke viscosity, nhọrọ kwesịrị ekwesị, mma mkpuchi, ọdịdị dị mma karịa iji ihe ndị ọzọ, ntinye uche ya na-ejikarị 2% -10%.

HPMC dị ka onye nkwusioru. A na-ejikarị nkwadebe mmiri akwụsịtụ n'ụdị usoro onunu ogwu, nke bụ usoro mgbasa ozi dị iche iche nke ọgwụ siri ike na-adịghị edozi na mgbasa ozi mgbasa ozi mmiri. Nkwụsi ike nke usoro ahụ na-ekpebi àgwà nkwadebe mmiri mmiri kwụsịrị. HPMC colloidal ngwọta nwere ike ibelata siri ike-mmiri interface esemokwu, belata n'elu free ike nke siri ike ahụ, nke mere na heterogeneous dispersion usoro nēche na-eguzosi ike, bụ ihe magburu onwe nkwusioru gị n'ụlọnga. A na-eji HPMC eme ihe dị ka ihe na-ekpu mmiri maka ọdịda anya, yana ọdịnaya nke 0.45%-1.0%.