HPMC maka ọgwụgwọ ọrịa anụmanụ

Hydroxypropyl methylcellulose (HPMC) bụ polymer a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ, a na-ejikwa ya na nkwadebe nke ọgwụ anụmanụ. HPMC bụ mmiri na-agbaze mmiri, nke na-abụghị ionic cellulose ether nke sitere na cellulose eke. Ọ bụ polymer dị mma, nke na-ekwekọ n'ihe, na ihe na-emebi emebi nke a na-eji mee ka nkwụsi ike, njirimara rheological, na bioavailability nke ọgwụ anụmanụ. N'isiokwu a, anyị ga-atụle Njirimara na ojiji nke HPMC na ọgwụgwọ ọrịa anụmanụ.

Njirimara nke HPMC

HPMC bụ polymer synthetic nke sitere na cellulose. O nwere ọtụtụ ihe na-eme ka ọ dị mma maka ọgwụgwọ ọrịa anụmanụ. Njirimara ndị a gụnyere:

Mmiri solubility: HPMC bụ nke ukwuu mmiri-soluble, nke pụtara na ọ nwere ike mfe igbari na mmiri na ndị ọzọ aqueous ngwọta. Nke a na-eme ka ọ dị mfe itinye n'ime ọgwụ anụmanụ.

Omume pseudo-plastic: HPMC na-egosipụta omume pseudo-plastic, nke pụtara na ọ bụ thixotropic ma na-akpachapụ anya. Ngwongwo a na-enye ya ohere ibelata viscosity nke nkwusioru mgbe a na-etinye ya n'ahụ ike, nke na-eme ka ọ dị mfe inye ọgwụgwọ ọgwụgwọ ọrịa anụmanụ.

Ikike imepụta ihe nkiri: HPMC nwere ikike imepụta ihe nkiri dị mma, nke pụtara na ọ nwere ike mepụta oyi akwa nchekwa n'elu akụkụ nke ọgwụ anụmanụ, nke na-enyere aka chebe ha pụọ ​​​​na mmebi na mkpokọta.

Njirimara mucoadhesive: HPMC nwere ihe eji eme mucoadhesive, nke pụtara na ọ nwere ike ịrapara n'elu mucosal n'ime ahụ. Ihe onwunwe a bara uru karịsịa maka usoro nnyefe ọgwụ ọnụ na imi, n'ihi na ọ na-enye ohere maka oge kọntaktị ogologo oge na elu mucosal na mma ịṅụ ọgwụ ọjọọ.

Ojiji nke HPMC na ọgwụ anụmanụ

A na-eji HPMC na ọgwụ anụmanụ dị iche iche. Ụfọdụ n'ime ihe a na-ejikarị HPMC eme ihe na ọgwụ anụmanụ gụnyere:

Nkwụsi ike: A na-eji HPMC kwalite nkwụsi ike nke ọgwụ anụmanụ. Ọ nwere ike inye aka gbochie nchịkọta urughuru, flocculation, na sedimentation, nke nwere ike ime ka ndụ ọgwụ dịkwuo mma.

Rheological mgbanwe: HPMC nwere ike iji gbanwee rheological Njirimara nke ọgwụgwọ ọrịa anụmanụ. Ọ nwere ike inye aka belata viscosity nke ọgwụ, nke nwere ike ime ka ọ dị mfe inye ya.

Ntọhapụ a na-achịkwa: Enwere ike iji HPMC nweta ntọhapụ nke ọgwụ ndị sitere na ọgwụ anụmanụ. Ikike imepụta ihe nkiri nke HPMC na-enye ya ohere ịmepụta oyi akwa mkpuchi n'elu akụkụ ọgwụ, nke nwere ike belata ntọhapụ nke ọgwụ ahụ n'ime ahụ.

nkwalite bioavailability: HPMC nwere ike melite bioavailability nke ọgwụ na ọgwụ anụmanụ. Ngwongwo mucoadhesive nke HPMC na-enye ya ohere ịrapagidesi ike na elu mucosal n'ime ahụ, nke nwere ike imeziwanye mmịnye ọgwụ na bioavailability.

Ikpuchi ire ụtọ: Enwere ike iji HPMC kpuchie uto na-adịghị mma nke ọgwụ na ọgwụ anụmanụ. Nke a bara uru karịsịa maka nhazi ọnụ, n'ihi na ọ nwere ike ime ka ọgwụ ahụ dịkwuo ụtọ ma dị mfe inye anụmanụ.

Usoro ihe dị n'elu: A na-ejikwa HPMC n'ụdị usoro maka ọgwụ anụmanụ. Enwere ike iji ya dị ka thickener, stabilizer, na emulsifier na ude, ointments, na gels. Omume pseudo-plastic nke HPMC na-enye ya ohere imeziwanye mgbasa na nkwụsi ike nke usoro nhazi.

Usoro injectable: HPMC nwekwara ike iji n'ụdị ịgba ọgwụ mgbochi ọrịa anụmanụ. Enwere ike iji ya dị ka onye na-akwụsịtụ na ihe nkwalite viscosity iji meziwanye nkwụsi ike na njirimara rheological nke injection.

Mmechi

N'ikpeazụ, HPMC bụ polymer dị iche iche nke a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ, gụnyere na ọgwụ anụmanụ. Mmiri solubility ya, akparamagwa pseudo-plastic, ikike imepụta ihe nkiri, ihe ndị na-egbochi mucoadhesive, na ikike ịmachi uto na-eme ka ọ bụrụ ihe bara uru n'ichepụta ọgwụ anụmanụ. HPMC nwere ike imeziwanye nkwụsi ike, akụrụngwa rheological, bioavailability, na ịdị nhịahụ nke ọgwụ anụmanụ, na-eme ka ọ dị mfe inye ya ma dị irè karị n'ịgwọ anụmanụ.