HPMC maka nkwusioru ọkwa ọgwụ

Hydroxypropyl methylcellulose (HPMC) bụ polymer a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ, karịsịa maka ihe onwunwe ya na nkwadebe nke nkwusioru. HPMC bụ mmiri na-agbaze mmiri, nke na-abụghị ionic cellulose ether nke sitere na cellulose eke. Ọ bụ ihe nchekwa, ihe na-emekọrịta ihe, na ihe na-emebi emebi nke a na-eji eme ka nkwụsi ike, akụrụngwa rheological, na bioavailability nke nkwusioru ọgwụ. N'ime edemede a, anyị ga-atụle njirimara na ojiji nke HPMC na nkwụsị ọkwa ọkwa ọgwụ.

Njirimara nke HPMC

HPMC bụ polymer synthetic nke sitere na cellulose. Ọ nwere ọtụtụ ihe na-eme ka ọ dị mma maka iji ya na nkwụsị ọgwụ. Njirimara ndị a gụnyere:

Mmiri solubility: HPMC bụ nke ukwuu mmiri-soluble, nke pụtara na ọ nwere ike mfe igbari na mmiri na ndị ọzọ aqueous ngwọta. Nke a na-eme ka ọ dị mfe itinye n'ime nkwusioru ọgwụ.

Omume pseudo-plastic: HPMC na-egosipụta omume pseudo-plastic, nke pụtara na ọ bụ thixotropic ma na-akpachapụ anya. Ngwongwo a na-enye ya ohere ibelata viscosity nke nkwusioru ahụ mgbe a na-etinye ya n'ahụ ike, nke na-eme ka ọ dịkwuo mfe ịchịkwa nkwusioru ahụ.

Ikike imepụta ihe nkiri: HPMC nwere ikike imepụta ihe nkiri dị mma, nke pụtara na ọ nwere ike mepụta oyi akwa nchekwa n'elu ihe nkwusioru, nke na-enyere aka chebe ha pụọ ​​​​na mmebi na mkpokọta.

Njirimara mucoadhesive: HPMC nwere ihe eji eme mucoadhesive, nke pụtara na ọ nwere ike ịrapara n'elu mucosal n'ime ahụ. Ihe onwunwe a bara uru karịsịa maka usoro nnyefe ọgwụ ọnụ na imi, n'ihi na ọ na-enye ohere maka oge kọntaktị ogologo oge na elu mucosal na mma ịṅụ ọgwụ ọjọọ.

Ojiji nke HPMC na nkwusioru ọkwa ọgwụ ọgwụ

A na-eji HPMC n'ụdị nkwusioru ọkwa ọgwụ dị iche iche. Ụfọdụ n'ime ihe a na-ejikarị HPMC eme ihe na nkwụsị ọgwụ gụnyere:

Nkwụsi ike: A na-eji HPMC kwalite nkwụsi ike nke nkwusioru ọgwụ. Ọ nwere ike inye aka gbochie nchịkọta urughuru, flocculation, na sedimentation, nke nwere ike imeziwanye ndụ nchekwa nke nkwusioru ahụ.

Mgbanwe nke rheological: Enwere ike iji HPMC gbanwee njirimara rheological nke nkwusioru ọgwụ. Ọ nwere ike inye aka belata viscosity nke nkwusioru ahụ, nke nwere ike ime ka ọ dịkwuo mfe ịhazi nkwusioru ahụ.

Ntọhapụ a na-achịkwa: Enwere ike iji HPMC nweta ntọhapụ nke ọgwụ na-achịkwa site na nkwụsị ọgwụ. Ikike imepụta ihe nkiri nke HPMC na-enye ya ohere ịmepụta oyi akwa mkpuchi n'elu akụkụ ọgwụ, nke nwere ike belata ntọhapụ nke ọgwụ ahụ n'ime ahụ.

nkwalite bioavailability: HPMC nwere ike melite bioavailability nke ọgwụ na nkwusioru ọgwụ. Ngwongwo mucoadhesive nke HPMC na-enye ya ohere ịrapagidesi ike na elu mucosal n'ime ahụ, nke nwere ike imeziwanye mmịnye ọgwụ na bioavailability.

Ikpuchi ire ụtọ: Enwere ike iji HPMC kpuchie uto na-adịghị mma nke ọgwụ na nkwusioru ọgwụ. Ikike imepụta ihe nkiri nke HPMC na-enye ya ohere ịmepụta oyi akwa na-echebe gburugburu ọgwụ ahụ, nke nwere ike igbochi mwepụta nke ọgwụ ahụ n'ọnụ ma kpuchie uto ya.

Mmelite ndakọrịta: HPMC nwere ike melite ndakọrịta ọgwụ na nkwusioru ọgwụ. Ụdị mmiri na-edozi mmiri nke HPMC na-enye ya ohere igbari n'ime mmiri na ngwọta mmiri ndị ọzọ, nke nwere ike melite ndakọrịta nke ọgwụ na ndị ọzọ excipients na nkwusioru.

Mmechi

HPMC bụ polymer vasatail nke a na-ejikarị na ụlọ ọrụ ọgwụ maka akụrụngwa ya na nkwadebe nke nkwusioru. Mmiri ya solubility, pseudo-plastic omume, ike imepụta fim, mucoadhesive Njirimara, na biocompatibility na-eme ka ọ bụrụ polymer bara uru maka ịkwado nkwusioru ọgwụ.