HPMC maka ọgwụ

HPMCmaka ọgwụaghọwo otu n'ime ndị kasị ibu ego nkenlekọta ahụike naihe ndị na-emepụta ọgwụ n'ụlọ na ná mba ọzọ, n'ihi na HPMC maka ọgwụ nwere uru ndị ọzọ na-enweghị.

1. Mmiri solubility

HPMC maka ọgwụ bụ soluble na mmiri oyi n'okpuru 40 ℃ ma ọ bụ 70% ethanol. Ọ bụ isi ihe na-esighi ike na mmiri ọkụ n'elu 60 ℃, ma ọ nwere ike gelated.

2. Chemical inertia

HPMC maka ọgwụ bụ nke na-abụghị ionic cellulose ether, ngwọta ya enweghị ionic ụgwọ na metal salts ma ọ bụ ionic organic ogige, ya mere na nkwadebe nke mmepụta usoro, ndị ọzọ excipients adịghị emeghachi omume na ya.

3. Nkwụsi ike

Ọ kwụsiri ike ma acid na isi, enwere ike ịchekwa ya na oke PH 3 ~ 11 ogologo oge na-enweghị mgbanwe doro anya na viscosity. Ihe ngwọta mmiri nke HPMC nwere nguzogide mildew ma nwee ike idowe nkwụsi ike viscosity dị mma na nchekwa ogologo oge. Ndị na-emepụta ọgwụ na-eji HPMC maka ọgwụ, nkwụsi ike ya dị mma karịa iji ihe ndị na-emepụta omenala (dị ka dextrin, starch, wdg) dị mma.

4. viscosity na-agbanwe agbanwe

Enwere ike ijikọ ihe nrụpụta HPMC nke viscosity dị iche iche dabere na nha dị iche iche, viscosity ya nwere ike ịgbanwe dịka iwu ụfọdụ siri dị, ma nwee mmekọrịta dị mma na linear, yabụ enwere ike họrọ ya dị ka mkpa nke oke. 2. 5 metabolic inertia HPMC adịghị etinye obi gị dum na ahụ adịghị metabolized, adịghị enye okpomọkụ, n'ihi ya, ọ bụ ihe nchebe ọgwụ nkwadebe excipients. .

5. Nchekwa

HPMCmaka ọgwụa na-ewerekarị ihe na-adịghị egbu egbu na nke na-adịghị ewe iwe.

Hydroxypropyl methyl cellulose (HPMC) bụ ihe ngwọtacelluloseether mepụtara site na mmeghachi omume nke chloromethane na propylene oxide na cellulose bụ isi. Na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ eriri ọcha ma ọ bụ ntụ ntụ granular, enweghị isi. A na-etinye ya n'ọrụ na ụlọ ọrụ ọgwụ maka ihe karịrị afọ 40, a nakweere ya na mbipụta USP19 na mbipụta Chinese Pharmacopoeia 1990. O nwetala nsonaazụ dị mma na ihe mkpuchi ihe nkiri na ngwa nrapado.

Ọkwa ọgwụHPMChydroxypropyl methyl cellulose nwere nnukwu ihe a chọrọ na akụrụngwa, teknụzụ mmepụta na àgwà ngwaahịa. N'ime afọ ndị na-adịbeghị anya, n'okpuru nduzi nke iwu nchebe gburugburu ebe obibi na-esiwanye ike, ụfọdụ ụlọ ọrụ obere ihe enyemaka ọgwụ na East China ewepụla n'ahịa, na ọkwa ọgwụ.HPMChydroxypropyl methyl cellulosemaka ọgwụemetụtawokwa ụlọ ọrụ mmepụta ihe, ewepụla ụfọdụ ikike mmepụta ihe, na imeziwanye ike itinye uche.