1. Okwu mmalite
Na ụlọ ọrụ na-emepụta ọgwụ, ịchịkwa ntọhapụ ọgwụ na nkwụsi ike ọgwụ bụ ọrụ dị mkpa na nhazi ọgwụ. Hydroxypropyl Methylcellulose (HPMC) cellulose ether bụ polymer multifunctional ihe a na-ejikarị na-emepụta ọgwụ. HPMC abụrụla akụkụ dị mkpa nke ọtụtụ ụdị usoro ọgwụgwọ siri ike na nke siri ike n'ihi njirimara anụ ahụ na kemịkal ya pụrụ iche, ọkachasị ikike njigide mmiri dị mma.
2. Ọdịdị na Njirimara nke HPMC
HPMC bụ ngwakọta mmiri na-agbaze mmiri nke enwetara site na methylating na hydroxypropylating cellulose. Usoro ihe omimi ya nwere skeleton cellulose na methoxy (-OCH₃) na hydroxypropoxy (-OCH₂CHOHCH₃) na-enye HPMC nguzozi pụrụ iche nke hydrophilicity na hydrophobicity, na-enyere ya aka ịmepụta ngwọta viscous ma ọ bụ gel na mmiri. Ihe onwunwe a dị mkpa karịsịa na nhazi ọgwụ n'ihi na ọ na-enyere aka ịchịkwa ọnụego ntọhapụ na nkwụsi ike nke ọgwụ ahụ.
3. Usoro njigide mmiri nke HPMC
Ndogide mmiri nke HPMC bụ n'ihi ike ya ịmịkọrọ mmiri, zaa na ịmepụta gels. Mgbe HPMC nọ na gburugburu mmiri mmiri, ndị hydroxyl na ethoxy dị n'ime ụmụ irighiri ihe ya na-emekọrịta ihe na mmiri mmiri site na njikọ hydrogen, na-enye ya ohere ịmịnye nnukwu mmiri. Usoro a na-eme ka HPMC zaa ma mepụta gel viscoelastic nke ukwuu. Gel a nwere ike ịmepụta oyi akwa mgbochi na usoro ọgwụ, si otú a na-achịkwa mgbasa na ntọhapụ nke ọgwụ ahụ.
Mmụba mmiri na ọzịza: Mgbe ụmụ irighiri HPMC na-amịkọrọ mmiri n'ime mmiri, olu ha na-agbasa ma mepụta ngwọta dị elu ma ọ bụ gel. Usoro a na-adabere na njikọ hydrogen n'etiti ụdọ molekụla na hydrophilicity nke ọkpụkpụ cellulose. Ọzịza a na-enyere HPMC aka ijide na idowe mmiri, si otú ahụ na-ekere òkè na njide mmiri n'ụdị ọgwụ.
Nhazi gel: HPMC na-etolite gel mgbe agbazere na mmiri. Ọdịdị nke gel na-adabere n'ihe ndị dị ka ịdị arọ molekụla, ogo nke nnọchi na okpomọkụ nke ngwọta nke HPMC. Gel nwere ike ịmepụta oyi akwa mkpuchi n'elu ọgwụ ahụ iji gbochie oke mmiri na-efunahụ ya, karịsịa mgbe ebe dịpụrụ adịpụ dị. Ngwunye gel a nwere ike igbu oge mgbasa nke ọgwụ ahụ, si otú ahụ nweta mmetụta ntọhapụ na-adịgide adịgide.
4. Ngwa nke HPMC na usoro ọgwụ
A na-eji HPMC n'ụdị usoro onunu ogwu dị iche iche, gụnyere mbadamba nkume, gels, creams, nkwadebe anya na nkwado ntọhapụ.
Mbadamba ụrọ: N'ụdị mbadamba nkume, a na-ejikarị HPMC eme ihe dị ka ihe nkedo ma ọ bụ nke na-agbasa, na ikike njide mmiri ya nwere ike imeziwanye ike na bioavailability nke mbadamba nkume. N'otu oge ahụ, HPMC nwekwara ike ịchịkwa ntọhapụ nke ọgwụ ọjọọ site na-akpụ a gel oyi akwa, nke mere na ọgwụ na-eji nwayọọ nwayọọ na-ahapụ na eriri afọ tract, si otú ogologo oge nke ọgwụ ọjọọ eme ihe.
Gel na ude: N'ime nkwadebe n'elu, njigide mmiri nke HPMC na-enyere aka mee ka mmetụta dị nro nke nkwadebe ahụ dịkwuo mma, na-eme ka absorption nke ihe ndị na-arụ ọrụ na akpụkpọ ahụ dịkwuo mma ma na-adịgide adịgide. HPMC nwekwara ike ịbawanye mgbasa na nkasi obi nke ngwaahịa.
Nkwadebe anya: N'ime nkwadebe anya, njide mmiri na mmepụta ihe nkiri nke HPMC na-enyere aka ịbawanye oge obibi nke ọgwụ ahụ n'elu anya anya, si otú ahụ na-abawanye bioavailability na ọgwụgwọ ọgwụgwọ nke ọgwụ ahụ.
Nkwadebe ntọhapụ na-adịgide adịgide: A na-eji HPMC mee ihe dị ka ihe matriks na nkwadebe ntọhapụ na-adịgide adịgide, ma nwee ike ịchịkwa ntọhapụ nke ọgwụ ọjọọ site n'ịgbanwe nhazi na mgbaze omume nke akwa gel. Njide mmiri nke HPMC na-enyere aka nkwado nkwado-nhapu iji nọgide na-enwe ntọhapụ kwụsiri ike ruo ogologo oge, na-eme ka ọ dị irè nke ọgwụ ahụ.
5. Uru nke HPMC
Dị ka onye na-ejigide mmiri na nhazi ọgwụ, HPMC nwere uru ndị a:
Njide mmiri dị elu: HPMC nwere ike ịmịnye ma jide nnukwu mmiri, mepụta akwa gel kwụsiri ike, na-egbu oge mgbasa na ntọhapụ nke ọgwụ.
Ọdịiche dị mma: HPMC nwere ezigbo bioocompatibility, anaghị ebute nzaghachi mgbochi ma ọ bụ nsi, ma dabara maka usoro ọgwụ dị iche iche.
Nkwụsi ike: HPMC nwere ike idowe akụrụngwa anụ ahụ na kemịkalụ kwụsiri ike n'okpuru pH dị iche iche na ọnọdụ okpomọkụ, na-ahụ nkwụsi ike ogologo oge nke usoro ọgwụ.
Adjustability: Site n'ịgbanwe ịdị arọ molekụla na ogo nke nnọchi nke HPMC, njide mmiri ya na ike imepụta gel nwere ike gbanwee iji gboo mkpa usoro ọgwụ dị iche iche.
HPMC cellulose ether na-arụ ọrụ dị mkpa dị ka onye na-ejigide mmiri na nhazi ọgwụ. Ọdịdị ya pụrụ iche na ihe onwunwe ya na-enyere ya aka ịmịnye mmiri nke ọma, na-emepụta akwa gel siri ike, ma si otú a na-achịkwa ntọhapụ na nkwụsi ike nke ọgwụ. Ngwakọta nke HPMC na ikike ijide mmiri dị mma na-eme ka ọ bụrụ ihe dị mkpa na nhazi ọgwụ ọgbara ọhụrụ, na-enye nkwado siri ike maka mmepe na ngwa ọgwụ. N'ọdịnihu, na mmepe nke nkà na ụzụ ọgwụ na-aga n'ihu, atụmanya ngwa nke HPMC na nhazi ọgwụ ga-aba ụba.
Oge nzipu: Jul-08-2024