Ịmepụta oke nhazi nke HPMC na mkpuchi mbadamba bụ usoro dị mgbagwoju anya nke gụnyere ịghọta ihe anụ ahụ na kemịkal nke HPMC na otu esi enweta ọrụ mkpuchi a chọrọ site n'ịgbanwe nhazi ahụ.
Họrọ nkọwapụta viscosity HPMC kwesịrị ekwesị: HPMC nwere nkọwapụta viscosity dị iche iche. HPMC nwere viscosities dị iche iche ga-emetụta ọdịnaya siri ike na ihe na-emepụta ihe nkiri nke mkpuchi. Mpempe viscosity dị ala HPMC na-enyere aka ịbawanye ọdịnaya siri ike, mana ọ nwere ike ịdị mkpa ka ejikọta ya na akara ule HPMC ndị ọzọ iji nweta uru nke ụdị anụ ahụ dị iche iche.
Jiri nchikota otutu nkọwapụta HPMC: Na usoro kachasị mma, a na-ejikarị ọtụtụ HPMC nke nkọwapụta dị iche iche eme ihe n'otu oge iji jiri akụrụngwa anụ ahụ ha dị iche iche. Nchikota a na-eme ka mma mkpuchi na mma.
Ịgbakwunye plasticizers: Plasticizers dị ka polyethylene glycol (PEG), triethyl citrate, wdg nwere ike imezi mgbanwe nke ihe nkiri ahụ ma belata okpomọkụ mgbanwe iko (Tg), si otú ahụ na-emeziwanye ihe anụ ahụ nke mkpuchi.
Tụlee ntinye nke ngwọta mkpuchi: Ihe siri ike nke ihe mkpuchi mkpuchi nwere mmetụta dị ukwuu na arụmọrụ mkpuchi. Mkpuchi mmiri mmiri nwere nnukwu ihe siri ike nwere ike ibelata oge mkpuchi ma melite arụmọrụ mmepụta. Dịka ọmụmaatụ, mgbe ị na-eji Kollicoat® IR ihe ndị dabeere na IR, nchịkọta mkpuchi mkpuchi nwere ike ịdị elu ruo 30%.
Na-ebuli usoro ihe mkpuchi mkpuchi: parampat usoro mkpuchi, dị ka ọnụego ịgbasa, okpomọkụ mbata, okpomọkụ ite, nrụgide atomization, na ọsọ ite, ga-emetụta ogo mkpuchi na ịdị n'otu. Site n'ịgbanwe usoro ndị a, enwere ike nweta nsonaazụ mkpuchi kachasị mma.
Iji HPMC dị arọ dị ala ọhụrụ: HPMC ọhụrụ dị ala dị ala (dị ka hypromellose 2906, VLV hypromellose) nwere ike melite usoro mkpuchi mbadamba ma belata ọnụ ahịa. Site na ijikọ na HPMC a na-ahụkarị, enwere ike nweta ihe mkpuchi kwesịrị ekwesị na mkpuchi dị elu, enweghị nsogbu na-arapara n'okpuru ọnọdụ mkpuchi dị nro, yana mkpuchi ihe nkiri mbadamba siri ike.
Tụlee nkwụsi ike nke ihe mkpuchi mkpuchi: HPMCP bụ polymer kwụsiri ike nke ukwuu nke nkwụsi ike ya na-edobe n'okpuru ọnọdụ iru mmiri dị elu, nke dị oké mkpa iji hụ na ịdị mma nke mbadamba nkume mkpuchi n'oge nchekwa.
Gbanwee usoro nkwadebe nke ngwọta mkpuchi: N'ihe banyere ịkwadebe ihe mgbaze agwakọta, jiri nwayọọ nwayọọ tinye HPMCP ntụ ntụ na ihe mgbaze agwakọta iji zere ịmepụta agglomerates. Ihe ndị ọzọ dị na ngwọta mkpuchi dị ka plasticizers, pigments na talc dịkwa mkpa ka agbakwunye ya dị ka ọ dị mkpa.
Tụlee ihe ndị dị na ọgwụ ahụ: Solubility na nkwụsi ike nke ọgwụ ahụ ga-emetụta nhọrọ nke nhazi mkpuchi. Dịka ọmụmaatụ, maka ọgwụ ndị na-ese foto, enwere ike ịchọ ihe mkpuchi iji chebe ọgwụ ahụ site na mmebi.
Na-eduzi nyocha nke vitro na ọmụmụ nkwụsi ike: Site na in vitro dissolution test na nkwụsi ike ọmụmụ, enwere ike nyochaa arụmọrụ nke mbadamba nkume mkpuchi iji hụ na ịdị irè na nkwụsi ike nke usoro mkpuchi na ngwa bara uru.
Site comprehensively na-atụle n'elu ihe na imezi dị ka kpọmkwem mmepụta ọnọdụ na ọgwụ e ji mara, usoro usoro nke HPMC na mbadamba mkpuchi nwere ike kacha iji nweta oru oma, edo na kwụsiri ike mkpuchi mmetụta.
Oge nzipu: Ọkt-29-2024