Hydroxypropyl methylcellulose (HPMC) bụ polymer a na-ejikarị eme ihe na nkwadebe ọgwụ, nke a na-ejikarị agbatị oge ntọhapụ nke ọgwụ. HPMC bụ ihe nrụpụta cellulose nke ọkara sịntetị nwere mmiri solubility yana ihe na-emepụta ihe nkiri. Site n'ịgbanwe ịdị arọ molekụla, itinye uche, viscosity na ihe ndị ọzọ nke HPMC, enwere ike ịchịkwa ntọhapụ nke ọgwụ ike nke ọma, si otú ahụ nweta ntọhapụ ọgwụ na-adịte aka ma na-adịgide adịgide.
1. Ọdịdị na usoro ntọhapụ ọgwụ nke HPMC
A na-emepụta HPMC site na hydroxypropyl na methoxy nnọchi nke usoro cellulose, usoro kemịkal ya na-enye ya ọzịza dị mma na ihe na-emepụta ihe nkiri. Mgbe ị na-akpakọrịta na mmiri, HPMC na-amịkọrọ mmiri ngwa ngwa ma zaa iji mepụta akwa gel. Nhazi nke akwa gel a bụ otu n'ime usoro dị mkpa maka ịchịkwa ntọhapụ ọgwụ. Ọnụnọ nke oyi akwa gel na-egbochi ntinye ọzọ nke mmiri n'ime matrix ọgwụ, na mgbasa nke ọgwụ na-egbochi gel Layer, si otú ahụ na-egbu oge ntọhapụ nke ọgwụ ahụ.
2. Ọrụ HPMC na nkwado ntọhapụ
N'ime nkwadebe ntọhapụ na-adịgide adịgide, a na-ejikarị HPMC eme ihe dị ka matriks ntọhapụ na-achịkwa. A na-agbasasị ma ọ bụ gbazee ọgwụ ahụ na matriks HPMC, mgbe ọ na-abanye na kọntaktị na eriri afọ, HPMC na-aza ma na-etolite akwa gel. Ka oge na-aga, oyi akwa gel na-eji nwayọọ nwayọọ na-arị elu, na-eme ihe mgbochi anụ ahụ. A ga-ahapụrịrị ọgwụ ahụ n'ime oghere dị n'èzí site na mgbasa ma ọ bụ mmebi nke matriks. Usoro ọrụ ya gụnyere akụkụ abụọ ndị a:
Usoro ọzịza: Mgbe HPMC batara na mmiri, oyi akwa dị n'elu na-amịkọrọ mmiri wee zaa iji mepụta akwa gel viscoelastic. Ka oge na-aga, oyi akwa gel na-eji nwayọọ nwayọọ gbasaa n'ime ya, oyi akwa dị n'èzí na-aza ma na-apụ apụ, na oyi akwa dị n'ime na-anọgide na-emepụta akwa gel ọhụrụ. Ọzịza a na-aga n'ihu na usoro nhazi gel na-achịkwa ọnụego ntọhapụ nke ọgwụ ahụ.
Usoro mgbasa ozi: Mgbasa ọgwụ site na oyi akwa gel bụ usoro ọzọ dị mkpa iji chịkwaa ọnụego ntọhapụ. Ngwunye gel nke HPMC na-arụ ọrụ dị ka ihe mgbochi mgbasa, yana ọgwụ kwesịrị ịgafe oyi akwa a iji ruo ọkara in vitro. Ibu molekụla, viscosity na itinye uche nke HPMC na nkwadebe ga-emetụta njirimara nke akwa gel, si otú ahụ na-achịkwa ọnụego mgbasa ozi nke ọgwụ.
3. Ihe na-emetụta HPMC
Enwere ọtụtụ ihe na-emetụta arụmọrụ ntọhapụ a na-achịkwa nke HPMC, gụnyere ịdị arọ molekụla, viscosity, usoro onunu ogwu nke HPMC, ihe anụ ahụ na kemịkalụ nke ọgwụ ahụ, yana gburugburu mpụga (dị ka pH na ike ionic).
Ibu molecular na viscosity nke HPMC: Ka ibu molekụla nke HPMC na-ebuwanye ibu, ka viscosity nke oyi akwa jel na-adị elu ma jiri nwayọọ nwayọọ na-ahapụ ọnụego ọgwụ. HPMC nwere viscosity dị elu nwere ike ịmepụta akwa gel siri ike karị, na-egbochi ọnụego mgbasa nke ọgwụ ahụ, si otú ahụ na-agbatị oge ntọhapụ nke ọgwụ ahụ. Ya mere, na imewe nke nkwado ntọhapụ na-adịgide adịgide, a na-ahọrọ HPMC nwere ihe dị iche iche dị arọ na viscosities dị ka mkpa iji nweta mmetụta ntọhapụ a tụrụ anya ya.
Ntinye uche nke HPMC: Ntinye nke HPMC bụkwa ihe dị mkpa n'ịchịkwa ọnụego mwepụta ọgwụ. Ọnụ ọgụgụ dị elu nke HPMC, ka ọkpụkpụ gel na-etolite, na-abawanye nguzogide mgbasa nke ọgwụ site na akwa gel, na-eji nwayọọ nwayọọ na-ahapụ ọnụego. Site n'ịgbanwe usoro onunu ogwu nke HPMC, enwere ike ịchịkwa oge ntọhapụ nke ọgwụ ahụ n'ụzọ dị nro.
Njirimara physicochemical nke ọgwụ: Mmiri solubility, arọ molecular, solubility, wdg nke ọgwụ ahụ ga-emetụta omume ntọhapụ ya na matrix HPMC. Maka ọgwụ ndị nwere mmiri mmiri dị mma, ọgwụ ahụ nwere ike ịgbaze na mmiri ngwa ngwa ma gbasaa site na oyi akwa gel, ya mere ọnụego ntọhapụ dị ngwa ngwa. Maka ọgwụ ndị na-enweghị mmiri na-adịghị mma, ihe na-edozi ahụ dị ala, ọgwụ ahụ na-agbasa nwayọọ nwayọọ na oyi akwa gel, na oge ntọhapụ dị ogologo.
Mmetụta nke gburugburu mpụga: Njirimara gel nke HPMC nwere ike ịdị iche na gburugburu nwere ụkpụrụ pH dị iche iche na ike ionic. HPMC nwere ike igosi àgwà ọzịza dị iche iche na gburugburu acidic, si otú a na-emetụta ọnụego ntọhapụ nke ọgwụ. N'ihi nnukwu pH mgbanwe na eriri afọ mmadụ, omume nke HPMC matrix kwadoro-mwepụta nkwadebe n'okpuru ọnọdụ pH dị iche iche chọrọ nlebara anya pụrụ iche iji hụ na enwere ike ịhapụ ọgwụ ahụ n'ụzọ kwụsiri ike ma na-aga n'ihu.
4. Ngwa nke HPMC dị iche iche na-achịkwa-ntọhapụ nkwadebe
A na-eji HPMC eme ihe n'ọtụtụ ebe n'ịkwado nkwado mwepụta nke ụdị ọgwụgwọ dị iche iche dị ka mbadamba, capsules na granules. Na mbadamba nkume, HPMC dị ka ihe matriks nwere ike ịmepụta ngwakọta ọgwụ-polymer otu ma jiri nwayọọ nwayọọ hapụ ọgwụ ahụ n'ime eriri afọ. Na capsules, a na-ejikarị HPMC eme ihe dị ka akpụkpọ anụ a na-achịkwa-achịkwa iji kpuchie ụmụ irighiri ọgwụ, na oge ntọhapụ nke ọgwụ ahụ na-achịkwa site n'ịgbanwe oke na viscosity nke mkpuchi mkpuchi.
Ngwa dị na mbadamba: Mbadamba ụrọ bụ ụdị usoro onunu a na-ahụkarị, a na-ejikarị HPMC nweta nsonaazụ ntọhapụ nke ọgwụ. Enwere ike ịgwakọta HPMC na ọgwụ ma pịkọta ya ka ọ bụrụ usoro matriks gbasasịrị n'otu n'otu. Mgbe mbadamba nkume na-abanye n'ime eriri afọ, elu HPMC na-agba ọsọ ngwa ngwa ma mepụta gel, nke na-ebelata nkwụsị nke ọgwụ ahụ. N'otu oge ahụ, ka oyi akwa gel na-aga n'ihu, a na-eji nwayọọ nwayọọ na-achịkwa ntọhapụ nke ọgwụ dị n'ime.
Ngwa na capsules:
Na nkwadebe capsule, a na-ejikarị HPMC eme ihe dị ka akpụkpọ ahụ ntọhapụ a na-achịkwa. Site n'ịgbanwe ọdịnaya nke HPMC na capsule na ọkpụrụkpụ nke ihe nkiri mkpuchi, enwere ike ịchịkwa ọnụego ntọhapụ nke ọgwụ ahụ. Na mgbakwunye, HPMC nwere ezigbo solubility na biocompatibility na mmiri, yabụ ọ nwere atụmanya ngwa sara mbara na sistemụ ntọhapụ nke capsule.
5. Ọdịnihu mmepe mmepe
Site na ọganihu nke nkà na ụzụ ọgwụ, ngwa nke HPMC abụghị nanị na nkwadebe ntọhapụ na-adịgide adịgide, ma enwere ike jikọta ya na usoro nnyefe ọgwụ ọhụrụ ndị ọzọ, dị ka microspheres, nanoparticles, wdg, iji nweta ntọhapụ ọgwụ na-achịkwa nke ọma. Na mgbakwunye, site n'ịgbanwe usoro nke HPMC, dị ka ịgwakọta ya na polymers ndị ọzọ, mgbanwe kemịkalụ, wdg, arụmọrụ ya na nkwadebe ntọhapụ a na-achịkwa nwere ike ime ka ọ dịkwuo mma.
HPMC nwere ike ịgbatị oge ntọhapụ ọgwụ nke ọma site na usoro ọzịza ya iji mepụta akwa gel. Ihe ndị dị ka ịdị arọ molekụla, viscosity, itinye uche nke HPMC na njirimara physicochemical nke ọgwụ ahụ ga-emetụta mmetụta ntọhapụ ya na-achịkwa. N'ime ngwa bara uru, site n'ichepụta ọnọdụ ojiji nke HPMC, enwere ike nweta ntọhapụ nke ụdị ọgwụ dị iche iche iji gboo mkpa ụlọ ọgwụ. N'ọdịnihu, HPMC nwere atụmanya ngwa sara mbara n'ọhịa nke ntọhapụ ọgwụ na-adịgide adịgide, enwere ike jikọta ya na teknụzụ ọhụrụ iji kwalite mmepe nke usoro nnyefe ọgwụ.
Oge nzipu: Sep-19-2024