Hydroxypropyl Methylcellulose (HPMC) bụ ether nke na-abụghị ionic cellulose ether na-esi na isi mmalite pụta. A na-eji ya eme ihe n'ọtụtụ ụlọ ọrụ dị iche iche, gụnyere ọgwụ, ihe owuwu, na nri, n'ihi na ọ na-eme ka ọ dị mma, na-emepụta ihe nkiri, na-ejigide mmiri. Usoro dị mkpa na mmepụta nke HPMC bụ etherification, nke na-eme ka njirimara arụmọrụ ya dịkwuo elu.
Usoro etherification
Etherification na-agụnye mmeghachi omume kemịkalụ nke cellulose na ihe ndị na-emepụta alkylating dị ka methyl chloride na propylene oxide. Mmeghachi omume a na-edochi otu hydroxyl (-OH) na azụ azụ cellulose na otu ether (-OR), ebe R na-anọchite anya otu alkyl. Maka HPMC, a na-eji hydroxypropyl na methyl dochie otu hydroxyl dị iche iche, na-eduga na nguzobe nke hydroxypropyl methyl ether dị n'akụkụ eriri cellulose.
Usoro kemịkalụ
A na-emekarị etherification nke cellulose na ọkara alkaline iji kwalite mmeghachi omume n'etiti otu cellulose hydroxyl na ihe ndị na-emepụta ihe. Enwere ike ịchịkọta usoro a na usoro ndị a:
Nrụ ọrụ nke Cellulose: A na-ebu ụzọ gwọọ cellulose na ngwọta alkaline, nke na-abụkarị sodium hydroxide (NaOH), iji mepụta cellulose alkali.
Alkylation: alkali cellulose na-emeghachi omume na methyl chloride (CH₃Cl) na propylene oxide (C₃H₆O), na-eduga na nnọchi nke otu hydroxyl na methyl na hydroxypropyl otu, n'otu n'otu.
Neutralization na Ịdị Ọcha: A na-ewepụ ngwakọta mmeghachi omume ahụ, a na-asakwa ngwaahịa ahụ iji wepụ ihe ndị na-adịghị ọcha na ihe ndị na-adịghị emezigharị.
Mmetụta na Njirimara anụ ahụ na kemịkal
Etherification na-emetụta mmetụta anụ ahụ na kemịkal nke HPMC, na-eme ka ọ bụrụ ihe na-arụ ọrụ nke ukwuu n'ofe ngwa dị iche iche.
Solubility na Gelation
Otu n'ime mgbanwe kachasị mkpa nke etherification kpatara bụ mgbanwe na solubility. Nwa afọ cellulose bụ insoluble na mmiri, ma etherified cellulose ethers dị ka HPMC na-aghọ mmiri-soluble n'ihi iwebata nke ether iche iche, nke na-akpaghasị hydrogen bonding netwọk na cellulose. Mgbanwe a na-enye HPMC ohere igbari na mmiri oyi, na-emepụta ngwọta doro anya, viscous.
Etherification na-emetụtakwa omume gelation nke HPMC. N'elu kpo oku, aqueous ngwọta nke HPMC na-enweta thermal gelation, na-akpụ a gel Ọdịdị. Enwere ike ịhazi okpomọkụ gelation na ike nke gel site n'ịgbanwe ogo nke nnọchi (DS) na ngbanwe nke molar (MS), nke na-ezo aka na nkezi ọnụ ọgụgụ nke hydroxyl dị iche iche na-anọchi anya otu glucose na nkezi ọnụ ọgụgụ nke mole nke nnọchi. kwa nkeji glucose, n'otu n'otu.
Njirimara Rheological
Njirimara rheological nke HPMC dị oke egwu maka ngwa ya dị ka onye na-agba ume na stabilizer. Etherification na-eme ka ihe ndị a dịkwuo mma site n'ịba ụba nke molekụla na iwebata ìgwè ether na-agbanwe agbanwe, nke na-eme ka omume viscoelastic nke ngwọta HPMC dịkwuo mma. Nke a na-ebute arụmọrụ dị elu nke ukwuu, omume ịkpacha mma nke ọma, yana nkwụsi ike dị mma megide mgbanwe okpomọkụ na pH.
Ikike imepụta ihe nkiri
Iwebata otu ether site na etherification na-akwalitekwa ikike imepụta ihe nkiri nke HPMC. Ihe onwunwe a bara uru karịsịa na ngwa dị ka mkpuchi na mkpuchi na ọgwụ na ụlọ ọrụ nri. Ihe nkiri ndị HPMC hibere doro anya, na-agbanwe agbanwe ma na-enye ezigbo ihe mgbochi megide mmiri na ikuku oxygen.
Ngwa emelitere site na Etherification
Ngwongwo emelitere nke HPMC n'ihi etherification na-agbatị ike ya n'ofe ụlọ ọrụ dị iche iche.
Ụlọ ọrụ ọgwụ
N'ọgwụ ọgwụ, a na-eji HPMC dị ka onye na-ekekọta ihe, onye na-eme ihe nkiri, na onye na-ewepụta ihe na-achịkwa n'ụdị mbadamba. Usoro etherification na-achọpụta na HPMC na-enye profaịlụ ntọhapụ ọgwụ na-agbanwe agbanwe, na-eme ka bioavailability dịkwuo mma, ma na-eme ka nkwụsi ike nke ihe ndị na-emepụta ọgwụ na-arụ ọrụ (APIs). Ngwongwo gelation thermal nke HPMC bara uru karịsịa n'ịzụlite usoro nnyefe ọgwụ na-enwe mmetụta okpomọkụ.
Ụlọ ọrụ ihe owuwu
HPMC na-eje ozi dị ka ihe mgbakwunye dị oke mkpa na ihe owuwu dịka ciment, ngwa agha, na plasta. Ikike njide mmiri ya, nke a na-emeziwanye site na etherification, na-eme ka ọgwụgwọ kachasị mma nke ihe cimenti, na-eme ka ike ha na ịdịte aka dịkwuo elu. Tụkwasị na nke ahụ, ihe ndị na-agbakọ na adhesion nke HPMC na-eme ka arụ ọrụ na ngwa ngwa nke ihe owuwu dị.
Ụlọ ọrụ nri
N'ime ụlọ ọrụ nri, a na-eji HPMC eme ihe dị ka ihe na-agbapụta, emulsifier, na stabilizer. Etherification na-eme ka solubility ya na viscosity dịkwuo mma, na-eme ka ọ dị mma maka ngwaahịa nri dị iche iche, gụnyere sauces, uwe, na ihe ebe a na-eme achịcha. HPMC na-etolitekwa ihe nkiri na mkpuchi oriri, na-agbatị ndụ ngwaahịa nri site na inye mmiri mmiri na ihe mgbochi oxygen.
Echiche Ọdịnihu na Ihe ịma aka
Ọ bụ ezie na etherification na-eme ka arụmọrụ HPMC dịkwuo elu, enwere ihe ịma aka na-aga n'ihu na mpaghara maka nyocha n'ọdịnihu. Ịkwalite usoro etherification iji nweta njikwa ziri ezi n'elu DS na MS dị oké mkpa maka ịkwado akụrụngwa HPMC maka ngwa ngwa. Na mgbakwunye, mmepe nke ụzọ etherification na gburugburu ebe obibi na nke na-adigide dị mkpa iji gboo mkpa na-eto eto maka omume kemịl akwụkwọ ndụ akwụkwọ ndụ.
Etherification na-arụ ọrụ dị mkpa n'ịkwalite arụmọrụ Hydroxypropyl Methylcellulose (HPMC). Site n'ịgbanwe ọkpụkpụ azụ cellulose na otu ether, usoro a na-enye nkwalite solubility, gelation, rheological properties, na ike imepụta ihe nkiri na HPMC. Ngwongwo ndị a kwalitere na-agbasa ngwa ya n'ofe ụlọ ọrụ dị iche iche, gụnyere ọgwụ, ihe owuwu na nri. Ka nyocha na-aga n'ihu, njikarịcha nke usoro etherification na mmepe nke ụzọ na-adịgide adịgide ga-anọgide na-emeghe ikike ọhụrụ maka HPMC, na-eme ka ọnọdụ ya dị ka ihe bara uru na-arụ ọrụ.
Oge nzipu: Jun-05-2024