Cellulose ethers bụ klas nke polymers agbanweela dabere na cellulose, nke a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ n'ihi ọmarịcha anụ ahụ na kemịkal ha. Ụdị ya bụ isi gụnyere hydroxypropyl methylcellulose (HPMC), carboxymethyl cellulose (CMC) na methyl cellulose (MC). Ndị a cellulose ethers nwere ọtụtụ ngwa ngwa na ọgwụ, mbadamba mkpuchi, capsules, nkwado ntọhapụ na nkwadebe mmiri mmiri.
1. Ngwa na mbadamba na capsules
N'ime mbadamba mbadamba na capsule, a na-ejikarị cellulose ethers eme ihe dị ka ihe eji eme ihe, ihe nkwụsị na ihe mkpuchi. Dị ka ndị na-ekekọta, ha nwere ike welie njikọ dị n'etiti ihe ndị na-emepụta ọgwụ, nke mere na mbadamba nkume na-etolite usoro siri ike na oge siri ike na oge nkwụsịtụ kwesịrị ekwesị. Cellulose ethers nwekwara ike melite fluidity na mkpakọ nke ọgwụ ọjọọ eme ihe ma na-akwalite otu ịkpụzi.
Ihe nchikota: Dịka ọmụmaatụ, HPMC dị ka ihe nkedo nwere ike kesaa n'ụzọ zuru oke n'elu ihe nke ọgwụ, na-enye adhesion otu iji hụ na mbadamba nkume ndị ahụ na-ejigide ọdịdị kwụsiri ike n'oge mkpakọ.
Mgbasa: Mgbe cellulose ethers zaa na mmiri, ha nwere ike ime ka ọnụ ọgụgụ mbadamba nkume gbasaa nke ọma nke ọma ma hụ na mwepụta ọgwụ ngwa ngwa. MC na CMC, dị ka disintegrants, nwere ike mee ngwangwa nkewa nke mbadamba nkume na eriri afọ tract na melite bioavailability nke ọgwụ ọjọọ eme ihe site na ha hydrophilicity na ọzịza Njirimara.
Ihe mkpuchi: Cellulose ethers dị ka HPMC na-ejikarị maka mkpuchi mbadamba na capsules. Ngwunye mkpuchi nwere ike ọ bụghị nanị na-ekpuchi uto ọjọọ nke ọgwụ ahụ, kamakwa inye mkpuchi nchebe iji belata mmetụta nke iru mmiri gburugburu ebe obibi na nkwụsi ike ọgwụ.
2. Ngwa na nkwado nkwado-nhapu
Cellulose ethers na-ekere òkè dị mkpa na nkwadebe ntọhapụ na-adịgide adịgide ma na-ejikarị achịkwa ọnụego ntọhapụ nke ọgwụ. Site n'ịgbanwe ụdị, viscosity na ntinye nke cellulose ethers, ndị na-ere ọgwụ nwere ike ịmepụta usoro ntọhapụ ọgwụ dị iche iche iji nweta ntọhapụ na-egbu oge, ntọhapụ na-achịkwa ma ọ bụ ntọhapụ ezubere iche.
Ndị ọrụ ntọhapụ a na-achịkwa: A na-eji ethers cellulose dị ka HPMC na EC (ethyl cellulose) dị ka ihe ntọhapụ a na-achịkwa na mbadamba ihe ntọhapụ. Ha nwere ike jiri nwayọọ nwayọọ gbazee n'ime ahụ iji mepụta akwa gel, si otú ahụ na-achịkwa ọnụego ntọhapụ nke ọgwụ ahụ ma na-ejigide mkpokọta plasma nke ọgwụ ahụ.
Ihe ọkpụkpụ: N'ime nkwadebe nkwado-mwepu ọkpụkpụ, cellulose ethers na-achụsasị ọgwụ ahụ na matriks site n'ịmepụta usoro netwọk iji mezie ọnụego mgbasa nke ọgwụ ahụ. Dịka ọmụmaatụ, ihe ọkpụkpụ HPMC na-etolite gels mgbe ekpughere ya na mmiri, na-egbochi mgbasa ngwa ngwa nke ọgwụ na ịnweta njikwa ogologo oge.
3. Ngwa na nkwadebe mmiri mmiri
A na-eji ethers cellulose eme ihe n'ọtụtụ ebe dị ka ndị na-ekpo ọkụ, ndị na-akwụsịtụ na ndị na-edozi ihe na nkwadebe mmiri. Ha nwere ike ịbawanye viscosity na nkwụsi ike nke nkwadebe mmiri mmiri ma gbochie ọgwụ ahụ idozi ma ọ bụ stratifying n'oge nchekwa.
Thickeners: Cellulose ethers (dị ka CMC) dị ka thickeners nwere ike ime ka viscosity nke mmiri mmiri nkwadebe, hụ na otu nkesa nke ọgwụ ọgwụ, na-egbochi ọgwụ ọjọọ.
Ndị ọrụ nkwụsị: A na-eji HPMC na MC mee ihe dị ka ihe nkwụsịtụ na nkwadebe mmiri iji hụ na a na-ekesa ihe ndị ahụ kwụsịtụrụ n'oge nkwadebe site n'ịmepụta usoro colloidal kwụsiri ike iji gbochie nkewa nke ọgwụ ọgwụ.
Stabilizers: Cellulose ethers nwekwara ike iji dị ka stabilizers melite kemịkalụ na anụ ahụ kwụsie ike nke mmiri nkwadebe n'oge nchekwa na ịgbatị ndụ adịkwa ọgwụ.
4. Ngwa ndị ọzọ
Na mgbakwunye, a na-ejikwa cellulose ethers na nkwadebe transdermal na nkwadebe anya na ụlọ ọrụ ọgwụ. Ha na-arụ ọrụ dị ka ndị na-eme ihe nkiri na ndị na-akwalite viscosity na ngwa ndị a iji melite nrapado na bioavailability nke nkwadebe.
Nkwadebe transdermal: A na-ejikarị HPMC na CMC eme ihe dị ka ndị na-eme ihe nkiri maka transdermal patches, nke na-eme ka mmịpụta transdermal nke ọgwụ dị mma site na ịchịkwa evaporation nke mmiri na ntinye ọgwụ.
Nkwadebe anya: N'ime nkwadebe anya, a na-eji cellulose ethers eme ihe dị ka ndị na-ekpo ọkụ iji meziwanye adhesion nke ọgwụ ophthalmic, na-agbatị oge obibi nke ọgwụ n'elu anya, ma melite mmetụta ọgwụgwọ.
Ngwa sara mbara nke cellulose ethers na ụlọ ọrụ na-emepụta ọgwụ sitere na njirimara anụ ahụ na nke kemịkal ha dị mma, dị ka ezigbo biocompatibility, solubility controllable na versatility iji gboo ihe achọrọ nke nkwadebe dị iche iche. Site n'iji ezi uche họrọ na ịkwalite cellulose ethers, ụlọ ọrụ ọgwụ nwere ike melite ogo na nkwụsi ike nke nkwadebe ọgwụ ma gboo mkpa ndị ọrịa maka nchekwa na ịdị irè ọgwụ. Site na ọganihu teknụzụ ọgwụ na-aga n'ihu, atụmanya ngwa nke cellulose ethers ga-aba ụba.
Oge nzipu: Jul-12-2024