Nke mbụ, ndebiri nke Bekee nke ihe inyeaka
MC: methyl cellulose
EC: ethyl cellulose
HPC: hydroxypropyl cellulose
HPMC: hydroxypropyl methylcellulose
CAP: Cellulose acetate phthalates
HPMCP: hydroxypropyl cellulose phthalates
HPMCAS: hydroxypropyl methyl cellulose acetate succinate
Cmc-na: sodium carboxymethyl cellulose
MCC: Microcrystalline cellulose
PVP: Povidone
PEG: polyethylene glycol
PVA: mmanya polyvinyl
Cms-na: sodium carboxymethyl starch
PVPP: povidone nwere njikọ
CCNa: sodium carboxymethyl cellulose na-ejikọta ya
Abụọ, iji ụfọdụ ihe inyeaka
1. Lactose: mbadamba nkume: filler, karịsịa ntụ ntụ ntụ ntụ ntụ ntụ ntụ ntụ; Ịgba ọgwụ: lyophilized nchebe
2. Microcrystalline cellulose: mbadamba nkume: ntụ ntụ ozugbo pịa mbadamba mbadamba; "Ihe nrapado akọrọ"; Mbadamba ụrọ nwere 20% microcrystalline cellulose na-arụ ọrụ dị ka disintegrators
3. Methyl cellulose: mbadamba nkume: nrapado; Onye nnọchi anya nkwusioru: enyemaka nkwusioru; Nkwadebe ntọhapụ nwayọ (na-achịkwa): hydrophilic gel skeleton material (adịghị ike)
4 sodium carboxymethyl cellulose: mbadamba: nrapado; Onye nnọchi anya nkwusioru: enyemaka nkwusioru; Nkwadebe ntọhapụ nwayọ (na-achịkwa): hydrophilic gel skeleton material
5. Ethyl cellulose: mbadamba nkume: nrapado (enweghị ike ime na mmiri); Nkwadebe ntọhapụ ngwa ngwa (a na-achịkwa): ihe ọkpụkpụ ma ọ bụ ihe mkpuchi akpụkpọ anụ; Mgbasa siri ike: ihe na-ebu ihe na-adịghị ike
6 hydroxypropyl cellulose: mbadamba nkume: nrapado, ihe mkpuchi ihe nkiri; Onye nnọchi anya nkwusioru: enyemaka nkwusioru; Nkwadebe ntọhapụ nwayọ (a na-achịkwa): hydrophilic gel skeleton material, microporous membrane kpuchiri mpempe akwụkwọ na-akpali akpali.
7. Hydroxypropyl methyl cellulose (hydroxypropyl methyl cellulose): mbadamba nkume: nrapado, ihe mkpuchi ihe nkiri; Onye nnọchi anya nkwusioru: enyemaka nkwusioru; Nkwadebe ntọhapụ nwayọ ma na-achịkwa: hydrophilic gel skeleton material, microporous membrane kpuchiri mpempe akwụkwọ na-akpali akpali.
8. Cellulose acetate phthalates: ihe ntinye
9. Hydroxypropyl cellulose phthalates: ihe ntinye
10. Hydroxypropyl cellulose acetate succinate: ihe ntinye
11. Polyvinyl phthalate (PVAP): ihe ntinye
12. Styrene Maleic acid copolymer (StyMA): eriri afọ soluble ihe.
13. Acrylic resin (ụdị enteric I, II, III), Eudragit L, Eudragit S (mgbe ụfọdụ Eudragit L100 ma ọ bụ Eudragit S 100): ihe na-arụ ọrụ.
14.Eudragit RL, Eudragit RS: ihe na-ebu ihe na-adịghị ike
15.Eudragit E (dakọtara na acrylic IV): ihe na-eme ka ọ bụrụ ihe na-edozi ahụ.
16. Cellulose acetate: mmiri na-adịghị edozi ihe, nwere ike iji maka mkpuchi ma ọ bụ nkwadebe nke mbadamba osmotic mgbapụta.
17. Polyvinylpyrrolidone (povidone PVP): mbadamba nkume: adhesives; Mbadamba ụrọ: ihe mkpuchi ihe mkpuchi ihe nkiri soluble gastric; Pellets: nifedipine pellets (mgbasa siri ike); Onye nnọchi anya nkwusioru: enyemaka nkwusioru;
Mgbasa siri ike: ihe na-ebu mmiri na-agbaze; Nkwadebe ntọhapụ ngwa ngwa (a na-achịkwa): hydrophilic colloid skeleton material; Nkwadebe ntọhapụ nwayọ (na-achịkwa): ihe na-akpata pore na mbadamba ihe mkpuchi microporous
18. Polyvinyl mmanya: onye na-ahụ maka ihe nkiri: ihe nkiri na-emepụta ihe, enyemaka nkwusioru
19. Sodium carboxymethyl starch: mbadamba nkume: onye na-ekesa
20. Cross-linked povidone: Mbadamba ụrọ: disintegrant
21. Crosslinked sodium carboxymethyl cellulose: mbadamba: disintegrating gị n'ụlọnga
22. Hydroxypropyl cellulose dị ala dochie anya: Mbadamba ụrọ: disintegrant
23. Polylactic acid: ihe onwunwe polymer biodegradable, nke a na-eji maka nkwadebe nke microspheres, nanoparticles, wdg.
24. Glycerol (sorbitol propylene glycol na-arụ ọrụ nso na glycerol)
Nkwadebe mmiri mmiri: ihe mgbaze, ihe mgbaze injection, enyemaka nkwusioru, moisturizer
Plasticizer na capsule na ihe mkpuchi
Ude, usoro nnyefe transdermal: ndị na-akwalite ntinye
Na-abawanye wettability nke ọgwụ hydrophobic, osmotic pressure regulator na emulsion abụba abụba.
Glycerin gelatin (maka ointments, suppositories, siri ike mgbasa)
25. Glycerin gelatin
Ntube ọgwụ: matriks na-agbaze mmiri
Suppository: matriks na-agbaze mmiri
Ude: Matriks soluble mmiri
26. Sodium dodecyl sulfate (anionic surfactant)
Emulsion, ointments: emulsifiers
Ngwa wetting maka nkwadebe siri ike / mmanu maka mbadamba nkume
solubilizer
27. Polyethylene glycol (PEG)
Mbadamba ụrọ: mmanu na-agbaze mmiri (PEG 4000, 6000)
Mbadamba ụrọ: Plasticizer na ndenye mkpuchi ihe nkiri
Capsule: Igwe mmiri dị nro na-abụghị mmanu mmanu (PEG 400)
Mkpụrụ ọgwụ mwụda: matriks na-agbaze mmiri (PEG 4000, 6000,9300)
Suppository: matrix suppository
Aerosol: Ihe mgbaze na-adịghị anya (PEG 400, 600)
Ọgwụ: mgbaze (PEG 400, 600)
Nkwadebe mmiri mmiri: Ihe mgbaze (PEG 400, 600)
Mgbasa siri ike: ebu
Nkwadebe ntọhapụ nwayọ (na-achịkwa): ihe na-akpata pore na mbadamba ihe mkpuchi microporous
Nkwadebe absorption nke percutaneous: transdermal absorption enhancer
28. Poloxam (” zwitterionic “surfactant) A kpachapụ anya comrade hụrụ a discrepancy ebe a, ugbu a mezie ka” Poloxam “na-abụghị ionic surfactant, ọ bụghị zwitterionic surfactant!
Onye na-ebu mgbasa siri ike, matrix suppository, emulsifier maka ịgba ntụtụ ma ọ bụ infusion
Nchịkọta nke ọgwụ antiseptik na bacteriostatic
Hydroxyl benzene ester (neper gold), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (ọhụrụ ọcha), benzalkonium chloride (jie er die), chlorhexidine acetate, benzyl mmanya (mgbu mgbu) n'otu oge ahụ, cross-njikọ. nwere mmanya butyl atọ (mgbu mpaghara) n'otu oge ahụ, nitrobenzene, mercury, thimerosal, net disinfection, ortho-phenyl phenol, phenoxyethanol, mmanụ eucalyptus, mmanụ cinnamon, mmanụ pepemint, wdg.
Anọ, usoro igba ogwu
1/ Glucose injection, abụba emulsion maka intravenous injections, dextran, sodium chloride infusion, roba plọg na ndị ọzọ na-ekpo ọkụ na ịpị igba ogwu;
2/ Vitamin C injection, procaine hydrochloride injection, cortisone acetate injection, chloramphenicol eye drops are sterilized site na ikesa uzuoku;
3 / mmanụ injection, griiz matrix, ampoule na-eji usoro ọgwụgwọ okpomọkụ akọrọ;
4 / Asepsis ikuku ikuku, na-arụ ọrụ tebụl n'elu: ultraviolet sterilization usoro ma ọ bụ gas fumigation usoro;
5/ Aka, akụrụngwa aseptic: usoro ịgba ọgwụ mgbochi mmiri
6/ Insulin injection na ngwaahịa ndị ọzọ dị ndụ: usoro ịgba ọgwụ mgbochi
V. nhatanha ndị emetụtara
1. Noyes-whitney nhatanha: na-akọwa ọnụego mgbasa nke ọgwụ siri ike.
2. Critical ikwu iru mmiri nke ngwakọta
hygroscopicity nke P68 ntụ ntụ)
3. Ọnụ ego ngbanweSuppository P87)
4.Poiseuile usoro: kọwaa ihe na-emetụta nzacha (injection P124)
5. Ngụkọta usoro nhazi nke isotonic site na usoro iwetu ihe na-ekpo ọkụogwu ogbugba (P156)
6. Mgbakọ nke HLB uru nke ngwakọta surfactantmmiri mmiri P178)
Nkà na ụzụ nkwadebe dị mkpa
1. Microcapsule: usoro condensation (otu, mgbagwoju), ihe mgbaze na-abụghị ihe mgbaze, mgbanwe okpomọkụ usoro, mmiri mmiri ihicha usoro, ịgba ihicha usoro, ịgba condensation usoro, ikuku nkwusioru usoro, interface condensation usoro, radieshon crosslinking usoro.
2. Ngwakọta gụnyere: usoro ngwọta mmiri juru eju, usoro egweri, usoro ihicha oyi, usoro ịgbasa mmiri.
3. Mgbasa siri ike: usoro ịgbaze, usoro mgbaze, ihe mgbaze - usoro ịgbaze, ihe mgbaze - usoro ịgbasa mmiri, usoro egweri.
4. Liposomes: usoro ogwu ogbugba, usoro mgbasa ozi dị mkpa, usoro mgbasa ozi ultrasonic, usoro ikuku evaporation nke oge, usoro ihicha ifriizi.
5. Microspheres: emulsification - usoro ọgwụgwọ, usoro ịgbasa mmiri, usoro ihicha mmiri
6. Nanoparticles: micellar polymerization, emulsion polymerization, interfacial polymerization, mmiri mmiri ihicha usoro.
7. Pellet: esi granulation usoro, ịgba granulation usoro, mkpuchi ite ụzọ, extrusion sphericity usoro, centrifugal projectile usoro, mmiri mmiri ihicha usoro.
8 suppository: usoro mgbaze ọkụ, usoro ịpị oyi, usoro igwakorita
9. Ude: usoro egweri, usoro agbaze, usoro emulsification
Onye na-ahụ maka ihe nkiri 10: usoro mmepụta ihe nkiri slurry na-agbaze, usoro ihe nkiri na-agbaze nrụgide, usoro ihe nkiri mejupụtara
Asaa, ngwa nnọchite anya
1. Microcapsule: gelatin - chịngọm Arab
2. Ngwakọta ntinye: cyclodextrin
3. Mgbasa siri ike: PEG, PVP
4. Liposomes: phospholipid-cholesterol
5. Microspheres: gelatin, albumin, PLA, wdg
6. Suppository: koko butter
7. Ude: Petroleum jelii, wdg
Onye nnọchi anya ihe nkiri 8: PVA
Asato, oge ole na ole
1. A ga-ahapụ ampoule sterilized ihe karịrị awa 24;
2. Nchekwa mmiri maka injection agaghị agafe awa 12;
3. A ga-emecha ọgwụ mgbochi nke injections n'ozuzu n'ime awa 12 mgbe ite;
4. Infusion na nkwadebe ngwọta ga-agwụcha n'ime awa 4 nke sterilization
9. Ihe nyocha nke ọma metụtara nkwadebe ọgwụ
1. Mbadamba ụrọ: ọdịdị ọdịdị; Iberibe ịdị arọ dị iche; Isi ike na mgbaji; ogo na-agbasa; Mgbasa ma ọ bụ ntọhapụ; Ịdị n'otu nke ọdịnaya
2. Onye na-achụsa ihe: ịdị n'otu; Mmiri. Ọdịiche nke nha nha; Nyocha ahụike; Nyocha granularity
3. Granule: ọdịdị; Oke urughuru; Akọrọ arọ ọnwụ; Agbazekwa; Ihe dị iche nke ibu
4. Capsule: ọdịdị; Mmiri. Ọdịiche nke nha nha; Mgbasa na mgbasa.
5. Ntube ọgwụ: ọdịiche dị arọ; Nlebanya oke oge mgbasa, wdg.
6. Suppository: ọdịdị; Ọdịiche dị na ibu; Ogologo oge ịgbaze; Ebe mgbaze; Nnwale mgbasa nke in vitro na ule nnabata in vivo
7. Plasta: nha nha; Ibu; Oke microbial; Isi ọdịnaya nke ọgwụ; Njirimara anụ ahụ; Ihe mkpali; Nkwụsi ike; Ntọhapụ, ntinye na ntinye ọgwụ na ude.
8. Transdermal patches: ịdị arọ dị iche; Ọdịiche mpaghara; Ịdị n'otu nke ọdịnaya; Ogo ntọhapụ, wdg.
10. Nkọwa dị iche iche
1. Micro Capsule: ọ bụ obere capsule nke a kpụrụ site na ijichi ọgwụ siri ike ma ọ bụ mmiri mmiri (nke a na-akpọ capsule core) n'ime ihe okike ma ọ bụ nke sịntetik (nke a na-akpọ capsule). 1-5000 microns
2. Pellet: na-ezo aka na gburugburu gburugburu nwere dayameta na-erughị 2.5mm nke ọgwụ na ihe ndị na-emepụta ihe mejupụtara.
3. Microsphere: a ọkpụkpụ-ụdị microscopic sppherical entity kpụrụ site dissolving ma ọ bụ dispersive ọgwụ na kpuchie nke polymer ihe, na a urughuru size na-emekarị n'etiti 1 na 250μm.
4. Nanoparticles: ihe siri ike colloidal ahụ mejupụtara ihe ndị na-emepụta ihe na-emepụta ihe na-emepụta ihe na-emepụta ihe na-emepụta ihe na-emepụta ihe na-emepụta ihe na-emepụta ihe, na nha nha nke 10 ~ 1000nm.
5. Ịdaba onye na-ahụ maka ọgwụ: na-ezo aka na ọgwụ siri ike ma ọ bụ mmiri mmiri na ihe ndị kwesịrị ekwesị (nke a na-akpọkarị matriks) na-agbaze mixing mix, dobe n'ime condensate miscible, condensation condensation na mere nke obere pellet nkwadebe.
Oge nzipu: Sep-09-2022