Capsule Grade HPMC maka ngwa Pharma

Hydroxypropyl methylcellulose (HPMC) bụ polymer vasatail nke a na-ejikarị eme ihe na ụlọ ọrụ na-emepụta ọgwụ n'ihi njirimara ya pụrụ iche dị ka nnukwu solubility, biocompatibility, na adịghị egbu egbu. Capsule ọkwa HPMC, nke a makwaara dị ka hypromellose, ka emebere ya maka ojiji na shells capsule ọgwụ. N'ime edemede a, anyị ga-atụle njirimara, nrụpụta na ngwa nke ọkwa capsule HPMC.

Njirimara nke Capsule Grade HPMC

Capsule ọkwa HPMC bụ ọkara sịntetik, inert, na mmiri-soluble polymer ewepụtara na cellulose. Ọ bụ ntụ ntụ na-acha ọcha ma na-acha ọcha nke na-esighị isi, na-enweghị ụtọ, na nke na-enweghị isi. Ihe ndị bụ isi nke ọkwa HPMC capsule bụ:

Nnukwu solubility: Capsule ọkwa HPMC na-agbaze ngwa ngwa n'ime mmiri wee mepụta ngwọta doro anya. Ọ nwere obere okpomọkụ gelation, nke pụtara na ọ nwere ike ịmepụta gels na obere okpomọkụ.

Enweghị nsi: Capsule ọkwa HPMC bụ polymer anaghị egbu egbu nke dị mma maka oriri mmadụ. Ndị ụlọ ọrụ nchịkwa dị iche iche dị ka US FDA, European Pharmacopoeia na Japanese Pharmacopoeia kwadoro ya.

Biocompatibility: Capsule grade HPMC dakọtara na sistemu ndu na anaghị ebute nsogbu ọ bụla na ahụike mmadụ.

Nkwụsi ike pH: Capsule ọkwa HPMC kwụsiri ike n'ọtụtụ pH ụkpụrụ, nke na-eme ka ọ dị mma maka ojiji na gburugburu acidic, nnọpụiche na gburugburu.

Njirimara ndị na-emepụta ihe nkiri: Capsule ọkwa HPMC nwere ike ịmepụta ihe nkiri siri ike ma na-agbanwe agbanwe nke na-eguzogide mgbawa, peeling, na imebi.

Njirimara ntọhapụ a na-achịkwa: Enwere ike iji ọkwa Capsule HPMC iji chịkwaa ntọhapụ nke ọgwụ sitere na shei capsule, nke na-eme ka ọ baa uru maka ịmepụta usoro mwepụta agbatị.

Nrụpụta nke Capsule Grade HPMC

A na-emepụta ọkwa Capsule HPMC site na iji kemịkal na-agbanwe cellulose eke na propylene oxide na methyl chloride. Ogo ngbanwe (DS) nke HPMC dabere na oke nke propylene oxide na methyl chloride eji na mmeghachi omume. Uru DS na-egosi ọnụọgụ hydroxyl dị na cellulose nke ejiri hydroxypropyl na methyl dochie anya.

Capsule ọkwa HPMC dị na ọkwa dị iche iche, dabere na viscosity ya na ogo nke nnọchi ya. Viscosity nke HPMC bụ ihe atụ nke ịdị arọ molekụla ya na ogo polymerization. Ihe dị elu nke viscosity, nke dị elu nke ịdị arọ molekụla na ihe ngwọta dị ukwuu. Ogo nke nnọchi na-ekpebi ihe solubility na njirimara gelation nke HPMC.

Ngwa nke Capsule Grade HPMC

A na-eji HPMC ọkwa Capsule eme ihe n'ọtụtụ ebe na ụlọ ọrụ ọgwụ maka imepụta shells capsule. A na-eji shells capsule na-ekpuchi ihe ọgwụ na-enye usoro dị mma ma dị mma maka ibugara ndị ọrịa ọgwụ. Ngwa kachasị nke ọkwa capsule HPMC na ụlọ ọrụ ọgwụ bụ:

Capsules onye anaghị eri anụ: Capsule ọkwa HPMC bụ ihe na-ewu ewu ọzọ na capsules gelatin, nke sitere na isi mmalite anụmanụ. Capsules onye anaghị eri anụ mere sitere na HPMC dabara adaba maka iji ya na usoro anaghị eri anụ na enweghị mmiri ọdịnaya, nke na-eme ka ha kwụsie ike ma dị mfe ijikwa.

Usoro mwepụta ndị a na-achịkwa: Enwere ike iji ọkwa Capsule HPMC jikwaa ntọhapụ nke ọgwụ na shei capsule. Enwere ike ịchịkwa ọnụego mwepụta ọgwụ site na ịhazigharị viscosity na ogo nnọchi nke HPMC. Nke a na-eme ka ọkwa capsule HPMC bara uru maka ịmepụta usoro mwepụta agbatịgoro nke nwere ike inye nnyefe ọgwụ na-adịgide adịgide n'ime oge.

Capsules nwere mkpuchi ime: Enwere ike iji ọkwa Capsule HPMC mee capsules nwere mkpuchi enteric, nke emebere iji hapụ ọgwụ ahụ n'ime eriri afọ kama afọ. Capsules nwere mkpuchi nke enteric bara uru maka ọgwụ ndị na-emetụta gburugburu acidic nke afọ ma ọ bụ kpasuo iwe na mkpuchi afọ.

Ikpuchi ire ụtọ: Enwere ike iji ọkwa Capsule HPMC kpuchie uto ilu nke ọgwụ ndị nwere uto na-adịghị mma. Enwere ike iji HPMC mepụta mkpuchi na-atọ ụtọ na irighiri ọgwụ, nke nwere ike melite nnabata onye ọrịa yana nnabata.

Solubility nkwalite: Capsule ọkwa HPMC nwere ike melite solubility nke emezighị soluble ọgwụ ọjọọ eme ihe site na-akpụ a siri ike dispersion. Enwere ike iji HPMC kpuchie ụmụ irighiri ọgwụ ahụ ma melite akụrụngwa wet na mgbasa ha.

Ihe enyemaka: Enwere ike iji ọkwa Capsule HPMC mee ihe n'ụdị ọgwụ dị iche iche dịka mbadamba nkume, mmanụ mmanụ, na nkwusioru. Ọ nwere ike rụọ ọrụ dị ka ihe nkedo, disintegrant, emulsifier, na stabilizer, dabere na nhazi ahụ.

Mmechi

Ọkwa Capsule HPMC bụ polymer na-ejikarị eme ihe na ụlọ ọrụ ọgwụ. Ọ nwere ihe ndị pụrụ iche dị ka nnukwu solubility, adịghị egbu egbu, na biocompatibility, nke na-eme ka ọ bụrụ ihe kwesịrị ekwesị maka ojiji na shells capsule. Usoro mmepụta nke ọkwa capsule HPMC gụnyere kemịkal na-agbanwe cellulose eke na propylene oxide na methyl chloride iji nweta viscosity chọrọ na ogo nnọchi. Capsule ọkwa HPMC na-achọta ngwa dị iche iche na ụlọ ọrụ na-emepụta ọgwụ, dị ka n'ichepụta capsules anaghị eri anụ, usoro mwepụta a na-achịkwa, capsules nwere mkpuchi, ihe ụtọ-masking, solubility enhancement, na dị ka ihe na-akpali akpali n'ụdị dị iche iche.